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Gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase

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γ-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase
Identifiers
EC no.4.3.2.6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
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NCBIproteins

γ-L-Glutamyl-butirosin B γ-glutamyl cyclotransferase (EC 4.3.2.6, btrG (gene)) is an enzyme with systematic name γ-L-glutamyl-butirosin B γ-glutamyl cyclotransferase (5-oxo-L-proline producing).[1] This enzyme catalyses the following chemical reaction

γ-L-glutamyl-butirosin B butirosin B + 5-oxo-L-proline

The enzyme catalyses the last step in the biosynthesis of the aminoglycoside antibiotic butirosin B.

References

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  1. ^ Llewellyn NM, Li Y, Spencer JB (April 2007). "Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain". Chemistry & Biology. 14 (4): 379–86. doi:10.1016/j.chembiol.2007.02.005. PMID 17462573.
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