Galmic

Galmic
Identifiers
	IUPAC name methyl 6-amino-2-[[(4R,11R,18R)-18-(cyclohexylmethylcarbamoyl)-11-(9H-fluoren-9-ylcarbamoyl)-4,7,11,14,18,21-hexamethyl-2,9,16-trioxo-6,13,20-trioxa-3,10,17,22,23,24-hexazatetracyclo[17.2.1.15,8.112,15]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-4-carbonyl]amino]hexanoate;
CAS Number	762241-24-7 ;
PubChem CID	11636593;
ChemSpider	25046661 ;
ChEMBL	ChEMBL578918 ;
Chemical and physical data
Formula	C51H60N10O11
Molar mass	989.100 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c7cccc3c7-c4ccccc4C3NC(=O)C(C)(c(oc6C)nc6C(=O)NC2(C)C(=O)NC(C(=O)OC)CCCCN)NC(=O)c1nc(oc1C)C(C)(NC(=O)c5nc2oc5C)C(=O)NCC8CCCCC8;
	InChI InChI=1S/C51H60N10O11/c1-26-36-41(64)61-51(6,45(68)55-38-32-21-13-11-19-30(32)31-20-12-14-22-33(31)38)48-58-37(28(3)72-48)40(63)60-50(5,44(67)54-34(42(65)69-7)23-15-16-24-52)47-57-35(27(2)71-47)39(62)59-49(4,46(56-36)70-26)43(66)53-25-29-17-9-8-10-18-29/h11-14,19-22,29,34,38H,8-10,15-18,23-25,52H2,1-7H3,(H,53,66)(H,54,67)(H,55,68)(H,59,62)(H,60,63)(H,61,64)/t34-,49-,50-,51-/m0/s1 ;
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Galmic is a drug which acts as a selective, non-peptide agonist at the galanin receptors GAL_R.^[1] It has anticonvulsant, antidepressant and analgesic effects in animal studies,^[2] but also inhibits memory functions.^[3]

References

^ Ceide SC, Trembleau L, Haberhauer G, Somogyi L, Lu X, Bartfai T, Rebek J (November 2004). "Synthesis of galmic: a nonpeptide galanin receptor agonist". Proceedings of the National Academy of Sciences of the United States of America. 101 (48): 16727–32. Bibcode:2004PNAS..10116727C. doi:10.1073/pnas.0407543101. PMC 534730. PMID 15557002.
^ Bartfai T, Lu X, Badie-Mahdavi H, Barr AM, Mazarati A, Hua XY, Yaksh T, Haberhauer G, Ceide SC, Trembleau L, Somogyi L, Kröck L, Rebek J (July 2004). "Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests". Proceedings of the National Academy of Sciences of the United States of America. 101 (28): 10470–5. Bibcode:2004PNAS..10110470B. doi:10.1073/pnas.0403802101. PMC 478593. PMID 15240875.
^ Badie-Mahdavi H, Behrens MM, Rebek J, Bartfai T (June 2005). "Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice". Neuropeptides. 39 (3): 249–51. doi:10.1016/j.npep.2004.12.010. PMID 15944018. S2CID 2142254.

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