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Protein-coding gene in the species Homo sapiens
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 is a protein that in humans is encoded by the GNG3 gene .[ 5] [ 6]
G proteins are heterotrimers of alpha, beta, and gamma subunits. Gamma subunits, such as GNG3, contribute to the specificity of the hundreds of receptor signaling pathways involving G proteins (Schwindinger et al., 2004).[supplied by OMIM][ 6]
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Bell B, Xing H, Yan K, et al. (1999). "KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation" . J. Biol. Chem . 274 (12): 7982–6. doi :10.1074/jbc.274.12.7982 . PMID 10075696 .
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Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Cuello F, Schulze RA, Heemeyer F, et al. (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta" . J. Biol. Chem . 278 (9): 7220–6. doi :10.1074/jbc.M210304200 . PMID 12486123 .
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Schwindinger WF, Giger KE, Betz KS, et al. (2004). "Mice with Deficiency of G Protein γ3 Are Lean and Have Seizures" . Mol. Cell. Biol . 24 (17): 7758–68. doi :10.1128/MCB.24.17.7758-7768.2004 . PMC 506985 . PMID 15314181 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .