GMDS (gene)

GMDS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1T2A
Identifiers
Aliases	GMDS, GMD, SDR3E1, GDP-mannose 4,6-dehydratase
External IDs	OMIM: 602884; MGI: 1891112; HomoloGene: 75968; GeneCards: GMDS; OMA:GMDS - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	2,245,605 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	32,522,723 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; mucosa of transverse colon; ; Descending thoracic aorta; ; rectum; ; ascending aorta; ; duodenum; ; minor salivary glands; ; palpebral conjunctiva; ; right coronary artery; ; mucosa of sigmoid colon;
	Top expressed in
	Paneth cell; ; epithelium of stomach; ; large intestine; ; colon; ; duodenum; ; jejunum; ; left colon; ; ileum; ; rib; ; epithelium of small intestine;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; NADP+ binding; lyase activity; GDP-mannose 4,6-dehydratase activity; identical protein binding;
Cellular component	cytosol; extracellular exosome; cytoplasm;
Biological process	GDP-mannose metabolic process; 'de novo' GDP-L-fucose biosynthetic process; Notch signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2762
	218138
	ENSG00000112699
	ENSMUSG00000038372
	O60547
	Q8K0C9
	NM_001253846; NM_001500
	NM_146041
	NP_001240775; NP_001491
	NP_666153
	Wikidata
View/Edit Human	View/Edit Mouse

GDP-mannose 4,6 dehydratase is an enzyme that in humans is encoded by the GMDS gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112699 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038372 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sullivan FX, Kumar R, Kriz R, Stahl M, Xu GY, Rouse J, et al. (May 1998). "Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro". J Biol Chem. 273 (14): 8193–8202. doi:10.1074/jbc.273.14.8193. PMID 9525924.
^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, et al. (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–98. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
^ "Entrez Gene: GMDS GDP-mannose 4,6-dehydratase".

Ohyama C, Smith PL, Angata K, Fukuda MN, Lowe JB, Fukuda M (1998). "Molecular cloning and expression of GDP-D-mannose-4,6-dehydratase, a key enzyme for fucose metabolism defective in Lec13 cells". J. Biol. Chem. 273 (23): 14582–14587. doi:10.1074/jbc.273.23.14582. PMID 9603974.
Roos C, Kolmer M, Mattila P, Renkonen R (2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism". J. Biol. Chem. 277 (5): 3168–3175. doi:10.1074/jbc.M107927200. PMID 11698403.
Eshel R, Besser M, Zanin A, Sagi-Assif O, Witz IP (2002). "The FX enzyme is a functional component of lymphocyte activation". Cell. Immunol. 213 (2): 141–148. doi:10.1006/cimm.2001.1872. PMID 11831876.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–811. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112699 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038372 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9525924-5] Sullivan FX, Kumar R, Kriz R, Stahl M, Xu GY, Rouse J, et al. (May 1998). "Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro". J Biol Chem. 273 (14): 8193–8202. doi:10.1074/jbc.273.14.8193. PMID 9525924.

[pmid19027726-6] Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, et al. (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–98. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.

[entrez-7] "Entrez Gene: GMDS GDP-mannose 4,6-dehydratase".

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References

Further reading