GEFT

ARHGEF25
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2RGN
Identifiers
Aliases	ARHGEF25, GEFT, p63RhoGEF, Rho guanine nucleotide exchange factor 25
External IDs	OMIM: 610215; MGI: 1277173; HomoloGene: 32691; GeneCards: ARHGEF25; OMA:ARHGEF25 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	57,617,245 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	127,025,952 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right coronary artery; ; gastric mucosa; ; body of uterus; ; muscle layer of sigmoid colon; ; popliteal artery; ; tibial arteries; ; left uterine tube; ; myometrium; ; thoracic aorta;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; hippocampus proper; ; CA3 field; ; primary visual cortex; ; primary motor cortex; ; superior frontal gyrus; ; vas deferens; ; Region I of hippocampus proper; ; umbilical cord; ; lateral septal nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; cytosol; plasma membrane; myofibril; sarcomere; membrane;
Biological process	regulation of Rho protein signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	115557
	52666
	ENSG00000240771
	ENSMUSG00000019467
	Q86VW2
	Q9CWR0
	NM_001111270; NM_133483; NM_182947; NM_001347933
	NM_001166413; NM_028027; NM_001358557; NM_001358558
	NP_001104740; NP_891992; NP_001334862
	NP_001159885; NP_082303; NP_001345486; NP_001345487
	Wikidata
View/Edit Human	View/Edit Mouse

RAC/CDC42 exchange factor, also known as GEFT, is a human gene.^[5]

Interactions

GEFT has been shown to interact with RHOA.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000240771 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019467 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GEFT RAC/CDC42 exchange factor".
^ Lutz S, Freichel-Blomquist A, Rümenapp U, Schmidt M, Jakobs KH, Wieland T (May 2004). "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene". Naunyn-Schmiedeberg's Arch. Pharmacol. 369 (5): 540–6. doi:10.1007/s00210-004-0926-5. PMID 15069594. S2CID 19812449.

Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ (2008). "Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs". Science. 318 (5858): 1923–7. doi:10.1126/science.1147554. PMID 18096806. S2CID 2418867.
Bryan BA, Cai Y, Liu M (2006). "The Rho-family guanine nucleotide exchange factor GEFT enhances retinoic acid- and cAMP-induced neurite outgrowth". J. Neurosci. Res. 83 (7): 1151–9. doi:10.1002/jnr.20814. PMID 16496360. S2CID 11130365.
Bryan BA, Mitchell DC, Zhao L, Ma W, Stafford LJ, Teng BB, Liu M (2006). "Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT". Mol. Cell. Biol. 25 (24): 11089–101. doi:10.1128/MCB.25.24.11089-11101.2005. PMC 1316953. PMID 16314529.
Lutz S, Freichel-Blomquist A, Yang Y, Rümenapp U, Jakobs KH, Schmidt M, Wieland T (2005). "The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA". J. Biol. Chem. 280 (12): 11134–9. doi:10.1074/jbc.M411322200. PMID 15632174.
Bryan B, Kumar V, Stafford LJ, Cai Y, Wu G, Liu M (2004). "GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation". J. Biol. Chem. 279 (44): 45824–32. doi:10.1074/jbc.M406216200. PMID 15322108.
Lutz S, Freichel-Blomquist A, Rümenapp U, Schmidt M, Jakobs KH, Wieland T (2004). "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene". Naunyn-Schmiedeberg's Arch. Pharmacol. 369 (5): 540–6. doi:10.1007/s00210-004-0926-5. PMID 15069594. S2CID 19812449.
Guo X, Stafford LJ, Bryan B, Xia C, Ma W, Wu X, Liu D, Songyang Z, Liu M (2003). "A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration". J. Biol. Chem. 278 (15): 13207–15. doi:10.1074/jbc.M208896200. PMID 12547822.
Souchet M, Portales-Casamar E, Mazurais D, Schmidt S, Léger I, Javré JL, Robert P, Berrebi-Bertrand I, Bril A, Gout B, Debant A, Calmels TP (2002). "Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere". J. Cell Sci. 115 (Pt 3): 629–40. doi:10.1242/jcs.115.3.629. PMID 11861769.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000240771 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019467 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GEFT RAC/CDC42 exchange factor".

[pmid15069594-6] Lutz S, Freichel-Blomquist A, Rümenapp U, Schmidt M, Jakobs KH, Wieland T (May 2004). "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene". Naunyn-Schmiedeberg's Arch. Pharmacol. 369 (5): 540–6. doi:10.1007/s00210-004-0926-5. PMID 15069594. S2CID 19812449.

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Interactions

References

Further reading