Rab GDP dissociation inhibitor beta is a protein that in humans is encoded by the GDI2gene.[5][6]
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Sedlacek Z, Munstermann E, Mincheva A, Lichter P, Poustka A (Feb 1998). "The human rab GDI beta gene with long retroposon-rich introns maps to 10p15 and its pseudogene to 7p11-p13". Mamm Genome. 9 (1): 78–80. doi:10.1007/s003359900685. PMID9434952. S2CID36441100.
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID1602151.
Bächner D, Sedlacek Z, Korn B, et al. (1995). "Expression patterns of two human genes coding for different rab GDP-dissociation inhibitors (GDIs), extremely conserved proteins involved in cellular transport". Hum. Mol. Genet. 4 (4): 701–8. doi:10.1093/hmg/4.4.701. PMID7543319.
Nishimura N, Goji J, Nakamura H, et al. (1995). "Cloning of a brain-type isoform of human Rab GDI and its expression in human neuroblastoma cell lines and tumor specimens". Cancer Res. 55 (22): 5445–50. PMID7585614.
Shisheva A, Doxsey SJ, Buxton JM, Czech MP (1996). "Pericentriolar targeting of GDP-dissociation inhibitor isoform 2". Eur. J. Cell Biol. 68 (2): 143–58. PMID8575461.
Shisheva A, Chinni SR, DeMarco C (1999). "General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications". Biochemistry. 38 (36): 11711–21. doi:10.1021/bi990200r. PMID10512627.
Weitzdoerfer R, Stolzlechner D, Dierssen M, et al. (2002). "Reduction of nucleoside diphosphate kinase B, Rab GDP- dissociation inhibitor beta and histidine triad nucleotide-binding protein in fetal Down Syndrome brain". Protein Expression in Down Syndrome Brain. pp. 347–59. doi:10.1007/978-3-7091-6262-0_29. ISBN978-3-211-83704-7. PMID11771757. {{cite book}}: |journal= ignored (help)
Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID16130169. S2CID26007149.
Sun ZL, Zhu Y, Wang FQ, et al. (2007). "Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers". Biochim. Biophys. Acta. 1774 (6): 764–71. doi:10.1016/j.bbapap.2007.04.001. PMID17507299.