GCFC2

GCFC2
Identifiers
Aliases	GCFC2, C2orf3, DNABF, GCF, TCF9, GC-rich sequence DNA-binding factor 2
External IDs	OMIM: 189901; MGI: 2141656; HomoloGene: 2411; GeneCards: GCFC2; OMA:GCFC2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	75,710,985 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	81,959,915 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; gastrocnemius muscle; ; right lobe of liver; ; Achilles tendon; ; muscle of thigh; ; canal of the cervix; ; right uterine tube; ; body of pancreas; ; gonad; ; ectocervix;
	Top expressed in
	hand; ; superior cervical ganglion; ; tail of embryo; ; otolith organ; ; utricle; ; foot; ; epiblast; ; genital tubercle; ; Rostral migratory stream; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding;
Cellular component	nucleolus; nucleus; U2-type post-mRNA release spliceosomal complex; nucleoplasm; cytosol;
Biological process	mRNA processing; spliceosomal complex assembly; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; RNA splicing; mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	6936
	330361
	ENSG00000005436
	ENSMUSG00000035125
	P16383
	Q8BKT3
	NM_001201334; NM_001201335; NM_003203
	NM_177884
	NP_001188263; NP_001188264; NP_003194
	NP_808552
	Wikidata
View/Edit Human	View/Edit Mouse

GC-rich sequence DNA-binding factor is a protein that in humans is encoded by the GCFC2 gene.^[5]^[6]^[7]^[8]

The first mRNA transcript isolated for this gene was part of an artificial chimera derived from two distinct gene transcripts and a primer used in the cloning process (see Genbank accession M29204). A positively charged amino terminus present only in the chimera was determined to bind GC-rich DNA, thus mistakenly thought to identify a transcription factor gene.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000005436 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035125 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Johnson AC, Kageyama R, Popescu NC, Pastan I (Feb 1992). "Expression and chromosomal localization of the gene for the human transcriptional repressor GCF". J Biol Chem. 267 (3): 1689–94. doi:10.1016/S0021-9258(18)46000-0. PMID 1370479.
^ Kageyama R, Pastan I (Jan 1990). "Molecular cloning and characterization of a human DNA binding factor that represses transcription". Cell. 59 (5): 815–25. doi:10.1016/0092-8674(89)90605-3. PMID 2556218. S2CID 21177070.
^ Anthoni H, Zucchelli M, Matsson H, Muller-Myhsok B, Fransson I, Schumacher J, Massinen S, Onkamo P, Warnke A, Griesemann H, Hoffmann P, Nopola-Hemmi J, Lyytinen H, Schulte-Korne G, Kere J, Nothen MM, Peyrard-Janvid M (Apr 2007). "A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia". Hum Mol Genet. 16 (6): 667–77. doi:10.1093/hmg/ddm009. PMID 17309879.
^ ^a ^b "Entrez Gene: C2orf3 chromosome 2 open reading frame 3".

External links

Human GCFC2 genome location and GCFC2 gene details page in the UCSC Genome Browser.

Mao P (1999). "[Revisions of the cDNA and primary protein structure of human transcription factor GCF]". Hokkaido Igaku Zasshi. 74 (4): 315–30. PMID 10480038.
Takimoto M, Mao P, Wei G, et al. (1999). "Molecular analysis of the GCF gene identifies revisions to the cDNA and amino acid sequences(1)". Biochim. Biophys. Acta. 1447 (1): 125–31. doi:10.1016/S0167-4781(99)00127-X. PMID 10500253.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000005436 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035125 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1370479-5] Johnson AC, Kageyama R, Popescu NC, Pastan I (Feb 1992). "Expression and chromosomal localization of the gene for the human transcriptional repressor GCF". J Biol Chem. 267 (3): 1689–94. doi:10.1016/S0021-9258(18)46000-0. PMID 1370479.

[pmid2556218-6] Kageyama R, Pastan I (Jan 1990). "Molecular cloning and characterization of a human DNA binding factor that represses transcription". Cell. 59 (5): 815–25. doi:10.1016/0092-8674(89)90605-3. PMID 2556218. S2CID 21177070.

[pmid17309879-7] Anthoni H, Zucchelli M, Matsson H, Muller-Myhsok B, Fransson I, Schumacher J, Massinen S, Onkamo P, Warnke A, Griesemann H, Hoffmann P, Nopola-Hemmi J, Lyytinen H, Schulte-Korne G, Kere J, Nothen MM, Peyrard-Janvid M (Apr 2007). "A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia". Hum Mol Genet. 16 (6): 667–77. doi:10.1093/hmg/ddm009. PMID 17309879.

[entrez-8] "Entrez Gene: C2orf3 chromosome 2 open reading frame 3".

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References

External links

Further reading