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Protein-coding gene in the species Homo sapiens
Polypeptide N-acetylgalactosaminyltransferase 2 is an enzyme that in humans is encoded by the GALNT2 gene .[ 5] [ 6] [ 7]
This gene encodes polypeptide N-acetylgalactosaminyltransferase 2 , a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis . The localization site of this particular enzyme is preponderantly the trans-Golgi .[ 8] O-glycosylation in a cell is regulated by a repertoire of GalNAc-transferases.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000143641 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000089704 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Bennett EP, Weghuis DO, Merkx G, van Kessel AG, Eiberg H, Clausen H (Jul 1998). "Genomic organization and chromosomal localization of three members of the UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferase family" . Glycobiology . 8 (6): 547–55. doi :10.1093/glycob/8.6.547 PMID 9592121 . ^ White T, Bennett EP, Takio K, Sorensen T, Bonding N, Clausen H (Dec 1995). "Purification and cDNA cloning of a human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase" . J Biol Chem . 270 (41): 24156–65. doi :10.1074/jbc.270.41.24156 PMID 7592619 . ^ a b "Entrez Gene: GALNT2 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)" .^ Netherton CL, McCrossan MC, Denyer M, Ponnambalam S, Armstrong J, Takamatsu HH, Wileman TE (November 2006). "African Swine Fever Virus Causes Microtubule-Dependent Dispersal of trans-Golgi Network" (PDF) . Journal of Virology . 80 (22): 11385–11392. doi :10.1128/JVI.00439-06 . PMC 1642160 PMID 16956944 .
Bennett EP, Hassan H, Clausen H (1996). "cDNA cloning and expression of a novel human UDP-N-acetyl-alpha-D-galactosamine. Polypeptide N-acetylgalactosaminyltransferase, GalNAc-t3" . J. Biol. Chem . 271 (29): 17006–12. doi :10.1074/jbc.271.29.17006 PMID 8663203 . Wandall HH, Hassan H, Mirgorodskaya E, et al. (1997). "Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3" . J. Biol. Chem . 272 (38): 23503–14. doi :10.1074/jbc.272.38.23503 PMID 9295285 . Müller S, Goletz S, Packer N, et al. (1997). "Localization of O-glycosylation sites on glycopeptide fragments from lactation-associated MUC1. All putative sites within the tandem repeat are glycosylation targets in vivo" . J. Biol. Chem . 272 (40): 24780–93. doi :10.1074/jbc.272.40.24780 PMID 9312074 . Röttger S, White J, Wandall HH, et al. (1998). "Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus". J. Cell Sci . 111 (1): 45–60. doi :10.1242/jcs.111.1.45 . PMID 9394011 . Mattu TS, Pleass RJ, Willis AC, et al. (1998). "The glycosylation and structure of human serum IgA1, Fab, and Fc regions and the role of N-glycosylation on Fc alpha receptor interactions" . J. Biol. Chem . 273 (4): 2260–72. doi :10.1074/jbc.273.4.2260 PMID 9442070 . Iwasaki H, Zhang Y, Tachibana K, et al. (2003). "Initiation of O-glycan synthesis in IgA1 hinge region is determined by a single enzyme, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2" . J. Biol. Chem . 278 (8): 5613–21. doi :10.1074/jbc.M211097200 PMID 12438318 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Marcos NT, Cruz A, Silva F, et al. (2003). "Polypeptide GalNAc-transferases, ST6GalNAc-transferase I, and ST3Gal-transferase I expression in gastric carcinoma cell lines". J. Histochem. Cytochem . 51 (6): 761–71. doi :10.1177/002215540305100607 . PMID 12754287 . S2CID 16133163 . Kinarsky L, Suryanarayanan G, Prakash O, et al. (2004). "Conformational studies on the MUC1 tandem repeat glycopeptides: implication for the enzymatic O-glycosylation of the mucin protein core" . Glycobiology . 13 (12): 929–39. doi :10.1093/glycob/cwg109 PMID 12925576 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1" . Nature . 441 (7091): 315–21. Bibcode :2006Natur.441..315G . doi :10.1038/nature04727 PMID 16710414 .
