Fucosyltransferase 4

FUT4
Identifiers
Aliases	FUT4, CD15, ELFT, FCT3A, FUC-TIV, FUTIV, LeX, SSEA-1, fucosyltransferase 4
External IDs	OMIM: 104230; MGI: 95594; HomoloGene: 1538; GeneCards: FUT4; OMA:FUT4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	94,549,895 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	14,663,689 bp
RNA expression pattern
	Top expressed in
	mucosa of sigmoid colon; ; bone marrow; ; mucosa of ileum; ; trabecular bone; ; monocyte; ; bone marrow cells; ; jejunal mucosa; ; duodenum; ; gonad; ; rectum;
	Top expressed in
	left colon; ; Paneth cell; ; epithelium of stomach; ; duodenum; ; granulocyte; ; seminal vesicula; ; transitional epithelium of urinary bladder; ; jejunum; ; mesenteric lymph nodes; ; conjunctival fornix;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; fucosyltransferase activity; glycosyltransferase activity; alpha-(1->3)-fucosyltransferase activity;
Cellular component	integral component of membrane; Golgi cisterna membrane; cell surface; Golgi apparatus; membrane; cell periphery; Golgi membrane;
Biological process	protein glycosylation; fucosylation; L-fucose catabolic process; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	2526
	14345
	ENSG00000196371
	ENSMUSG00000049307
	P22083
	Q11127
	NM_002033
	NM_010242
	NP_002024
	NP_034372
	Wikidata
View/Edit Human	View/Edit Mouse

Fucosyltransferase 4 is a protein that in humans is encoded by the FUT4 gene. ^[5]

Function

The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196371 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049307 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Fucosyltransferase 4". Retrieved 2018-05-20.

Barry SM, Zisoulis DG, Neal JW, Clipstone NA, Kansas GS (September 2003). "Induction of FucT-VII by the Ras/MAP kinase cascade in Jurkat T cells". Blood. 102 (5): 1771–8. doi:10.1182/blood-2002-11-3551. PMID 12738675.
Azuma Y, Ito M, Taniguchi A, Matsumoto K (June 2004). "Expression of cell surface Lewis X and Y antigens and FUT4 mRNA is increased in Jurkat cells undergoing apoptosis". Biochim. Biophys. Acta. 1672 (3): 157–63. doi:10.1016/j.bbagen.2004.03.006. PMID 15182935.
Martinez M, Joffraud M, Giraud S, Baïsse B, Bernimoulin MP, Schapira M, Spertini O (February 2005). "Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII". J. Biol. Chem. 280 (7): 5378–90. doi:10.1074/jbc.M410899200. PMID 15579466.
Higai K, Ichikawa A, Matsumoto K (September 2006). "Binding of sialyl Lewis X antigen to lectin-like receptors on NK cells induces cytotoxicity and tyrosine phosphorylation of a 17-kDa protein". Biochim. Biophys. Acta. 1760 (9): 1355–63. doi:10.1016/j.bbagen.2006.03.015. PMID 16842926.
Azuma Y, Kurusu Y, Sato H, Higai K, Matsumoto K (April 2007). "Increased expression of Lewis X and Y antigens on the cell surface and FUT 4 mRNA during granzyme B-induced Jurkat cell apoptosis". Biol. Pharm. Bull. 30 (4): 655–60. doi:10.1248/bpb.30.655. PMID 17409497.
Yang X, Zhang Z, Jia S, Liu Y, Wang X, Yan Q (2007). "Overexpression of fucosyltransferase IV in A431 cell line increases cell proliferation". Int. J. Biochem. Cell Biol. 39 (9): 1722–30. doi:10.1016/j.biocel.2007.04.024. PMID 17556010.
Cruse JM, Lewis RE, Sanders CM, Webb RN, Beason KL, Lam J, Koehler J (October 2007). "Diminished CD10, CD13, and CD15 expression in a differentiated granulocyte population in CML". Exp. Mol. Pathol. 83 (2): 274–6. doi:10.1016/j.yexmp.2007.05.005. PMID 17662271.
Zhang Z, Sun P, Liu J, Fu L, Yan J, Liu Y, Yu L, Wang X, Yan Q (February 2008). "Suppression of FUT1/FUT4 expression by siRNA inhibits tumor growth". Biochim. Biophys. Acta. 1783 (2): 287–96. doi:10.1016/j.bbamcr.2007.10.007. PMID 18023290.
Plesa C, Chelghoum Y, Plesa A, Elhamri M, Tigaud I, Michallet M, Dumontet C, Thomas X (February 2008). "Prognostic value of immunophenotyping in elderly patients with acute myeloid leukemia: a single-institution experience". Cancer. 112 (3): 572–80. doi:10.1002/cncr.23219. PMID 18085638. S2CID 42107018.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196371 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049307 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Fucosyltransferase 4". Retrieved 2018-05-20.

[1]

[2]

[3]

[4]

[5]

Function

References

Further reading