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Formate dehydrogenase (NADP+)

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formate dehydrogenase (NADP+)
Identifiers
EC no.1.17.1.10
CAS no.51377-43-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
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PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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In enzymology, a formate dehydrogenase (NADP+) (EC 1.17.1.10) is an enzyme that catalyzes the chemical reaction

formate + NADP+ CO2 + NADPH

Thus, the two substrates of this enzyme are formate and NADP+, whereas its two products are CO2 and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is formate:NADP+ oxidoreductase. Other names in common use include NADP+-dependent formate dehydrogenase, and formate dehydrogenase (NADP+). This enzyme participates in methane metabolism. It has 3 cofactors: iron, Tungsten, and Selenium.

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2GSD.

References

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  • Andreesen JR, Ljungdahl LG (1974). "Nicotinamide adenine dinucleotide phosphate-dependent formate dehydrogenase from Clostridium thermoaceticum: purification and properties". J. Bacteriol. 120 (1): 6–14. doi:10.1128/JB.120.1.6-14.1974. PMC 245723. PMID 4154039.
  • Yamamoto I, Saiki T, Liu SM, Ljungdahl LG (1983). "Purification and properties of NADP-dependent formate dehydrogenase from Clostridium thermoaceticum, a tungsten-selenium-iron protein". J. Biol. Chem. 258 (3): 1826–32. doi:10.1016/S0021-9258(18)33062-X. PMID 6822536.