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Flavastacin

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Flavastacin
Identifiers
EC no.3.4.24.76
CAS no.167973-66-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins

Flavastacin (EC 3.4.24.76) is an enzyme.[1] This enzyme catalyses the following chemical reaction

Hydrolyses polypeptides on the amino-side of Asp in -Xaa-Asp-. Acts very slowly on -Xaa-Glu

This zinc metalloendopeptidase belong to the peptidase family M12. It has recently been described as cleaving specifically after N-glycosylated asparagine, making it a potentially useful as a tool to analytically characterize glycoproteins.[2]

References

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  1. ^ Tarentino, A.L.; Quinones, G.; Grimwood, B.G.; Hauer, C.R.; Plummer, T.H. Jr. (1995). "Molecular cloning and sequence analysis of flavastacin: an O-glycosylated prokaryotic zinc metalloendopeptidase". Arch. Biochem. Biophys. 319: 281–285. doi:10.1006/abbi.1995.1293. PMID 7771796.
  2. ^ Pralow A, Hoffmann M, Nguyen-Khuong T, Rapp E, Reichl U (2017). "Improvement of the glycoproteomic toolbox with the discovery of a unique C-terminal cleavage specificity of flavastacin for N-glycosylated asparagine". Sci Rep. 7 (1): 11419. doi:10.1038/s41598-017-11668-1. PMC 5595805. PMID 28900186.
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