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English: The Evolution of Bacteria on a “Mega-Plate” Petri Dish: Bacteria (white) grow on a large petri dish with increasing concentrations of antibiotic (trimethoprim) in bands towards the center. Evolution of antibiotic resistance can be seen as mutants with higher antibiotic resistance are able to colonise the more central regions. By the 11th day of evolution, variants with 1000x higher antibiotic resistance have colonised the central band. Film played at 18000x speed (covering 11.7 days total).
العربية: تطور البكتيريا على طبق بتري ”بصفيحة ضخمة“: بكتيريا (بالأبيض) تنمو على طبق بتري ضخم من المضاد الحيوي (تريميثوبريم) موزعة على نطاقات تتزايد تراكيزها بالاتجاه نحو المركز. يمكن ملاحظة أن تطور مقاومة المضادات الحيوية يتبع قدرة الطفرات ذات المقاومة الأعلى للمضادات الحيوية على استيطان المناطق الأقرب للمركز. بحلول اليوم الحادي عشر من تطورها، تستعمر المتغيرات ذات المقاومة الأعلى للمضادات الحيوية بألف ضعفاً النطاقات الأوسط. يُعرض الفيلم بسرعة 18000 ضعفاً (ممتداً على فترة 11.7 يوماً).

Suggested thumbnail time: |thumbtime=1:40

Polski: Ewolucja bakterii na szalce Petriego typu Mega-Plate – bakterie (kolor biały) rozwijają się na ogromnej szalce Petriego podzielonej na obszary, w których koncentracja antybiotyku (trimetoprymu) wzrasta w kierunku środka szalki. Można zaobserwować ewolucję oporności na antybiotyki, gdy zmutowane bakterie o zwiększonej oporności są w stanie kolonizować obszary położone bliżej środka. Po 11 dniach ewolucji bakterie z tysiąckrotnie większą opornością na antybiotyki skolonizowały centralny obszar.
Čeština: Evoluce bakterií rostoucích na Petriho misce v přítomnosti antbiotika (trimethoprim). Bakterie (bílé) rostou od krajů misky směrem ke středu a část z nich mutuje a vytváří si antibiotickou rezistenci, takže zmutované bakterie po 11 dnech růstu ve středu misky mají 1000x vyšší odolnost vůči antibiotiku než původní kmen.
Македонски: Еволуција на бактерија која за релативно кратко време стекнува отпорност на ×1000 доза на антибиотик.
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Author Rkishony - Kishony Lab, Harvard Medical school & Technion, Israel Institute of Technology
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Other versions

Originally published: Baym, Michael (2016-09-09). "Spatiotemporal microbial evolution on antibiotic landscapes". Science 353 (6304): 1147–1151. DOI:10.1126/science.aag0822. PMID 27609891. ISSN 0036-8075.


Also hosted on: Harvard Medical School (2016-09-09). The Evolution of Bacteria on a “Mega-Plate” Petri Dish (Kishony Lab). YouTube. Retrieved on 2016-09-24.

Assessment

Media of the day This file was selected as the media of the day for 12 October 2016. It was captioned as follows:
English: The evolution of bacteria on a “Mega-Plate” petri dish: Bacteria (white) grow on a large petri dish with increasing concentrations of antibiotic (trimethoprim) in bands towards the center. Evolution of antimicrobial resistance can be seen as mutants with higher antibiotic resistance are able to colonise the more central regions. By the 11th day of evolution, variants with 1000x higher antibiotic resistance have colonised the central band.
Other languages
Čeština: Evoluce bakterií rostoucích na Petriho misce v přítomnosti antbiotika (trimethoprim). Bakterie (bílé) rostou od krajů misky směrem ke středu a část z nich mutuje a vytváří si antibiotickou rezistenci, takže zmutované bakterie po 11 dnech růstu ve středu misky mají 1000x vyšší odolnost vůči antibiotiku než původní kmen.
English: The evolution of bacteria on a “Mega-Plate” petri dish: Bacteria (white) grow on a large petri dish with increasing concentrations of antibiotic (trimethoprim) in bands towards the center. Evolution of antimicrobial resistance can be seen as mutants with higher antibiotic resistance are able to colonise the more central regions. By the 11th day of evolution, variants with 1000x higher antibiotic resistance have colonised the central band.
Македонски: Еволуција на бактерија која за релативно кратко време стекнува отпорност на ×1000 доза на антибиотик.
Polski: Ewolucja bakterii na szalce Petriego typu Mega-Plate – bakterie (kolor biały) rozwijają się na ogromnej szalce Petriego podzielonej na obszary, w których koncentracja antybiotyku (trimetoprymu) wzrasta w kierunku środka szalki. Można zaobserwować ewolucję oporności na antybiotyki, gdy zmutowane bakterie o zwiększonej oporności są w stanie kolonizować obszary położone bliżej środka. Po 11 dniach ewolucji bakterie z tysiąckrotnie większą opornością na antybiotyki skolonizowały centralny obszar.

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current10:37, 5 October 20161 min 55 s, 1,280 × 720 (6.93 MB)RkishonyVideoconvert upload from toollabs

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