File:Hcmvdrugs.pdf
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Summary
| Description |
English: Mechanisms of anti-HCMV compounds. Ganciclovir (GCV) is monophosphorylated by the HCMV protein kinase pUL97. Cidofovir (CDV) does not require initial phosphorylation for its antiviral action. Further phosphorylation to the triphosphate form of GCV and CDV is performed by cellular kinases. The nucleoside-triphosphate-analogues compete with the cellular nucleotide triphosphates at the viral polymerase pUL54 and are incorporated into the viral DNA. Foscarnet (FOS) directly inhibits polymerase function by blocking the pyrophosphate binding site. |
| Date | |
| Source | Own work |
| Author | Nepomuk78 |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 17:28, 13 April 2011 |  | 1,641 × 1,125 (90 KB) | Nepomuk78 | {{Information |Description ={{en|1=Mode of action of systemic HCMV drugs}} |Source ={{own}} |Author =Nepomuk78 |Date =2011-04-13 |Permission = |other_versions = }} |
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