DescriptionBrinster Male germline stem cell transplantation.tif
English: Diagram depicting male germline stem cell transplantation. The proposed clinical application of human spermatogonial stem cells (SSCs). Before treatment for cancer by chemotherapy or irradiation, a prepubertal boy could undergo a testicular biopsy to recover SSCs. The SSCs would be cryopreserved and/or cultured to expand their number in vitro. After treatment, the SSCs would be transplanted to the patient’s testes to produce spermatozoa. A step for genetic correction to rescue a genetic disorder is possible prior to transplantation.
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