Fidgetin-like 2
Fidgetin-like 2 (FL2) is a human enzyme that slows the rate at which skin cells migrate to wounds to heal them. If this enzyme is suppressed/absent, skin cells move faster, speeding the healing process.[1]
Delivery
[edit]Molecules of silencing RNA (siRNA) that bind to a gene's messenger RNA (mRNA) can inhibit the production of FL2, but siRNAs require protection from degradation in order to reach a wound site.[2]
In 2015, researchers disclosed the successful use of nanoparticles to ferry siRNA molecules to their intended targets, reducing healing times in mice with skin excisions or burns. The result was normal, well-orchestrated tissue, including hair follicles and supportive collagen network.[1][2]
References
[edit]- ^ a b Charafeddine, Rabab A.; Makdisi, J; Schairer, D; O'Rourke, BP; Diaz-Valencia, JD; Chouake, J; Kutner, A; Krausz, A; Adler, B; Nacharaju, P; Liang, H; Mukherjee, S; Friedman, JM; Friedman, A; Nosanchuk, JD; Sharp, DJ (10 March 2015). "Fidgetin-Like 2: A Microtubule-Based Regulator of Wound Healing". The Journal of Investigative Dermatology. 135 (9): 2309–18. doi:10.1038/jid.2015.94. PMC 4537388. PMID 25756798.
- ^ a b Moss, Richard (March 30, 2015). "Nanoparticles help wounds to heal 50 percent faster". Gizmag. Retrieved 3 April 2015.