Family with sequence similarity 19 member A4, C-C motif chemokine like

TAFA4
Identifiers
Aliases	TAFA4, TAFA-4, family with sequence similarity 19 (chemokine (C-C motif)-like), member A4, family with sequence similarity 19 member A4, C-C motif chemokine like, TAFA chemokine like family member 4, FAM19A4
External IDs	OMIM: 617498; MGI: 2444563; HomoloGene: 18561; GeneCards: TAFA4; OMA:TAFA4 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	68,953,297 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	97,037,374 bp
RNA expression pattern
	Top expressed in
	testicle; ; oocyte; ; secondary oocyte; ; lateral nuclear group of thalamus; ; right adrenal cortex; ; decidua; ; C1 segment; ; left adrenal gland; ; left adrenal cortex; ; prefrontal cortex;
	Top expressed in
	lumbar spinal ganglion; ; cumulus cell; ; primary oocyte; ; embryo; ; secondary oocyte; ; embryo; ; zygote; ; morula; ; epithelium of lens; ; spermatid;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; receptor ligand activity;
Cellular component	extracellular region; extracellular space;
Biological process	regulation of membrane potential; regulation of sensory perception of pain; phagocytosis; regulation of signaling receptor activity; superoxide anion generation; macrophage chemotaxis; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	151647
	320701
	ENSG00000163377
	ENSMUSG00000046500
	Q96LR4
	Q7TPG5
	NM_001005527; NM_182522
	NM_177233
	NP_001005527; NP_872328; NP_001005527.1; NP_872328.1
	NP_796207
	Wikidata
View/Edit Human	View/Edit Mouse

Family with sequence similarity 19 member A4, C-C motif chemokine like is a protein that in humans is encoded by the FAM19A4 gene. ^[5]

Function

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163377 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000046500 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Family with sequence similarity 19 member A4, C-C motif chemokine like". Retrieved 2017-12-09.

Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (2010). "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals". Am. J. Hypertens. 23 (1): 70–7. doi:10.1038/ajh.2009.190. PMID 19851296.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (2010). "Association of genetic variants with hemorrhagic stroke in Japanese individuals". Int. J. Mol. Med. 25 (4): 649–56. doi:10.3892/ijmm_00000388. PMID 20198315.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Wang W, Li T, Wang X, Yuan W, Cheng Y, Zhang H, Xu E, Zhang Y, Shi S, Ma D, Han W (2015). "FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1 (FPR1) and is able to promote the migration and phagocytosis of macrophages". Cell. Mol. Immunol. 12 (5): 615–24. doi:10.1038/cmi.2014.61. PMC 4579646. PMID 25109685.
De Strooper LM, Meijer CJ, Berkhof J, Hesselink AT, Snijders PJ, Steenbergen RD, Heideman DA (2014). "Methylation analysis of the FAM19A4 gene in cervical scrapes is highly efficient in detecting cervical carcinomas and advanced CIN2/3 lesions". Cancer Prev Res (Phila). 7 (12): 1251–7. doi:10.1158/1940-6207.CAPR-14-0237. PMID 25281488.
Luttmer R, De Strooper LM, Berkhof J, Snijders PJ, Dijkstra MG, Uijterwaal MH, Steenbergen RD, van Kemenade FJ, Rozendaal L, Helmerhorst TJ, Verheijen RH, Ter Harmsel WA, Van Baal WM, Graziosi PG, Quint WG, Heideman DA, Meijer CJ (2016). "Comparing the performance of FAM19A4 methylation analysis, cytology and HPV16/18 genotyping for the detection of cervical (pre)cancer in high-risk HPV-positive women of a gynecologic outpatient population (COMETH study)". Int. J. Cancer. 138 (4): 992–1002. doi:10.1002/ijc.29824. PMID 26317579.
De Strooper LM, Verhoef VM, Berkhof J, Hesselink AT, de Bruin HM, van Kemenade FJ, Bosgraaf RP, Bekkers RL, Massuger LF, Melchers WJ, Steenbergen RD, Snijders PJ, Meijer CJ, Heideman DA (2016). "Validation of the FAM19A4/mir124-2 DNA methylation test for both lavage- and brush-based self-samples to detect cervical (pre)cancer in HPV-positive women". Gynecol. Oncol. 141 (2): 341–347. doi:10.1016/j.ygyno.2016.02.012. PMC 4851217. PMID 26921784.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163377 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046500 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Family with sequence similarity 19 member A4, C-C motif chemokine like". Retrieved 2017-12-09.

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[5]

Function

References

Further reading