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Protein-coding gene in the species Homo sapiens
GSK-3-binding protein FRAT2 is a protein that in humans is encoded by the FRAT2 gene .[ 5] [ 6] [ 7]
The protein encoded by this intronless gene belongs to the GSK-3 -binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway . It may be upregulated in tumor progression.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000181274 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047604 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Yost C, Farr GH 3rd, Pierce SB, Ferkey DM, Chen MM, Kimelman D (Jul 1998). "GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis" . Cell . 93 (6): 1031–41. doi :10.1016/S0092-8674(00)81208-8 PMID 9635432 . S2CID 17951152 . ^ Saitoh T, Moriwaki J, Koike J, Takagi A, Miwa T, Shiokawa K, Katoh M (Mar 2001). "Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway". Biochem Biophys Res Commun . 281 (3): 815–20. doi :10.1006/bbrc.2001.4421 . PMID 11237732 . ^ a b "Entrez Gene: FRAT2 frequently rearranged in advanced T-cell lymphomas 2" .
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