FLRT1

FLRT1
Identifiers
Aliases	FLRT1, SPG68, fibronectin leucine rich transmembrane protein 1
External IDs	OMIM: 604806; MGI: 3026647; HomoloGene: 40864; GeneCards: FLRT1; OMA:FLRT1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	64,119,173 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	7,083,094 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; frontal pole; ; buccal mucosa cell; ; paraflocculus of cerebellum; ; ventral tegmental area; ; inferior ganglion of vagus nerve; ; cerebellar vermis; ; thalamus; ; globus pallidus; ; internal globus pallidus;
	Top expressed in
	olfactory epithelium; ; olfactory tubercle; ; medial dorsal nucleus; ; otolith organ; ; utricle; ; cingulate gyrus; ; primary motor cortex; ; human kidney; ; lumbar subsegment of spinal cord; ; globus pallidus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein-macromolecule adaptor activity; fibroblast growth factor receptor binding; protein kinase inhibitor activity;
Cellular component	cytoplasm; integral component of membrane; cell projection; endoplasmic reticulum membrane; membrane; cell-cell junction; focal adhesion; integral component of plasma membrane; neuronal cell body membrane; extracellular region; cell junction; endoplasmic reticulum; perinuclear region of cytoplasm; neuron projection terminus; cytoplasmic vesicle membrane; cytoplasmic vesicle; plasma membrane; extracellular space; extracellular matrix;
Biological process	negative regulation of protein kinase activity; cytokine-mediated signaling pathway; dendrite development; neuron projection extension; multicellular organism development; cell adhesion; negative regulation of receptor signaling pathway via JAK-STAT; positive regulation of synapse assembly; fibroblast growth factor receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	23769
	396184
	ENSG00000126500
	ENSMUSG00000047787
	Q9NZU1
	Q6RKD8
	NM_013280; NM_001384466
	NM_201411
	NP_037412
	NP_958813
	Wikidata
View/Edit Human	View/Edit Mouse

Fibronectin leucine rich transmembrane protein 1 is a protein that in humans is encoded by the FLRT1 gene. ^[5]

Function

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in the kidney and brain.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000126500 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047787 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Fibronectin leucine rich transmembrane protein 1". Retrieved 2017-05-30.

Function

References

Further reading