FK962

FK962
Identifiers
	IUPAC name N-(1-acetylpiperidin-4-yl)-4-fluorobenzamide;
CAS Number	283167-06-6;
PubChem CID	9816738;
ChemSpider	7992488;
UNII	25J7VT36F9;
ChEMBL	ChEMBL4303387;
Chemical and physical data
Formula	C14H17FN2O2
Molar mass	264.300 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(=O)N1CCC(CC1)NC(=O)C2=CC=C(C=C2)F;
	InChI InChI=1S/C14H17FN2O2/c1-10(18)17-8-6-13(7-9-17)16-14(19)11-2-4-12(15)5-3-11/h2-5,13H,6-9H2,1H3,(H,16,19); Key:VBHVOHJOTMCSBQ-UHFFFAOYSA-N;

FK962 is a compound which acts as an enhancer of somatostatin release. It stimulates nerve growth and neurite elongation, and has been researched in animal models for potential applications in the treatment of conditions such as Alzheimer's disease and retinal neuropathy.^[1]^[2]^[3]^[4]

References

^ Tokita K, Inoue T, Yamazaki S, Wang F, Yamaji T, Matsuoka N, Mutoh S (December 2005). "FK962, a novel enhancer of somatostatin release, exerts cognitive-enhancing actions in rats". European Journal of Pharmacology. 527 (1–3): 111–120. doi:10.1016/j.ejphar.2005.10.022. PMID 16325809.
^ McCarthy AD, Owens IJ, Bansal AT, McTighe SM, Bussey TJ, Saksida LM (March 2011). "FK962 and donepezil act synergistically to improve cognition in rats: potential as an add-on therapy for Alzheimer's disease". Pharmacology, Biochemistry, and Behavior. 98 (1): 76–80. doi:10.1016/j.pbb.2010.11.019. PMID 21130801. S2CID 26055819.
^ Kishimoto Y, Yabuta C, Shearer TR, Azuma M (August 2012). "FK962 promotes neurite elongation and regeneration of cultured rat trigeminal ganglion cells: possible involvement of GDNF". Investigative Ophthalmology & Visual Science. 53 (9): 5312–5319. doi:10.1167/iovs.11-8957. PMID 22714891.
^ Nakajima E, Walkup RD, Shearer TR, Azuma M (January 2017). "FK962 induces neurite outgrowth in cultured monkey trigeminal ganglion cells". Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie. 255 (1): 107–112. doi:10.1007/s00417-016-3525-5. PMID 27778122. S2CID 26043647.

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[1] Tokita K, Inoue T, Yamazaki S, Wang F, Yamaji T, Matsuoka N, Mutoh S (December 2005). "FK962, a novel enhancer of somatostatin release, exerts cognitive-enhancing actions in rats". European Journal of Pharmacology. 527 (1–3): 111–120. doi:10.1016/j.ejphar.2005.10.022. PMID 16325809.

[2] McCarthy AD, Owens IJ, Bansal AT, McTighe SM, Bussey TJ, Saksida LM (March 2011). "FK962 and donepezil act synergistically to improve cognition in rats: potential as an add-on therapy for Alzheimer's disease". Pharmacology, Biochemistry, and Behavior. 98 (1): 76–80. doi:10.1016/j.pbb.2010.11.019. PMID 21130801. S2CID 26055819.

[3] Kishimoto Y, Yabuta C, Shearer TR, Azuma M (August 2012). "FK962 promotes neurite elongation and regeneration of cultured rat trigeminal ganglion cells: possible involvement of GDNF". Investigative Ophthalmology & Visual Science. 53 (9): 5312–5319. doi:10.1167/iovs.11-8957. PMID 22714891.

[4] Nakajima E, Walkup RD, Shearer TR, Azuma M (January 2017). "FK962 induces neurite outgrowth in cultured monkey trigeminal ganglion cells". Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie. 255 (1): 107–112. doi:10.1007/s00417-016-3525-5. PMID 27778122. S2CID 26043647.

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See also

References