FARSA (gene)

FARSA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3L4G
Identifiers
Aliases	FARSA, CML33, FARSL, FARSLA, FRSA, PheHA, phenylalanyl-tRNA synthetase alpha subunit, phenylalanyl-tRNA synthetase subunit alpha, RILDBC2
External IDs	OMIM: 602918; MGI: 1913840; HomoloGene: 3280; GeneCards: FARSA; OMA:FARSA - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	12,934,037 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	85,595,886 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; mucosa of transverse colon; ; right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; Brodmann area 9; ; Brodmann area 10; ; gastrocnemius muscle; ; apex of heart; ; ganglionic eminence;
	Top expressed in
	spermatocyte; ; spermatid; ; embryo; ; morula; ; embryo; ; ventricular zone; ; neural layer of retina; ; blastocyst; ; yolk sac; ; lip;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	aminoacyl-tRNA ligase activity; tRNA binding; nucleotide binding; ligase activity; protein binding; ATP binding; phenylalanine-tRNA ligase activity; RNA binding;
Cellular component	cytoplasm; cytosol; membrane; phenylalanine-tRNA ligase complex;
Biological process	tRNA aminoacylation; protein biosynthesis; protein heterotetramerization; tRNA aminoacylation for protein translation; phenylalanyl-tRNA aminoacylation;
	Sources:Amigo / QuickGO
Orthologs
	2193
	66590
	ENSG00000179115
	ENSMUSG00000003808
	Q9Y285
	Q8C0C7
	NM_004461
	NM_025648
	NP_004452
	NP_079924
	Wikidata
View/Edit Human	View/Edit Mouse

Phenylalanyl-tRNA synthetase alpha chain is an enzyme that in humans is encoded by the FARSA gene.^[5]^[6]

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of regulated expression^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179115 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003808 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sen S, Zhou H, Ripmaster T, Hittelman WN, Schimmel P, White RA (Jul 1997). "Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent". Proc Natl Acad Sci U S A. 94 (12): 6164–9. Bibcode:1997PNAS...94.6164S. doi:10.1073/pnas.94.12.6164. PMC 21020. PMID 9177188.
^ ^a ^b "Entrez Gene: FARSA phenylalanyl-tRNA synthetase, alpha subunit".

Rodova M, Ankilova V, Safro MG (1999). "Human phenylalanyl-tRNA synthetase: cloning, characterization of the deduced amino acid sequences in terms of the structural domains and coordinately regulated expression of the alpha and beta subunits in chronic myeloid leukemia cells". Biochem. Biophys. Res. Commun. 255 (3): 765–73. doi:10.1006/bbrc.1999.0141. PMID 10049785.
Sang Lee J, Gyu Park S, Park H, et al. (2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochem. Biophys. Res. Commun. 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID 11829477.
Moor N, Linshiz G, Safro M (2002). "Cloning and expression of human phenylalanyl-tRNA synthetase in Escherichia coli: comparative study of purified recombinant enzymes". Protein Expr. Purif. 24 (2): 260–7. doi:10.1006/prep.2001.1560. PMID 11858721.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000179115 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003808 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9177188-5] Sen S, Zhou H, Ripmaster T, Hittelman WN, Schimmel P, White RA (Jul 1997). "Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent". Proc Natl Acad Sci U S A. 94 (12): 6164–9. Bibcode:1997PNAS...94.6164S. doi:10.1073/pnas.94.12.6164. PMC 21020. PMID 9177188.

[entrez-6] "Entrez Gene: FARSA phenylalanyl-tRNA synthetase, alpha subunit".

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References

Further reading