FAM151A

FAM151A
Identifiers
Aliases	FAM151A, C1orf179, family with sequence similarity 151 member A
External IDs	MGI: 2657115; HomoloGene: 17143; GeneCards: FAM151A; OMA:FAM151A - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	54,623,556 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	106,605,489 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; renal cortex; ; human kidney; ; testicle; ; mucosa of transverse colon; ; apex of heart; ; left ventricle; ; gonad; ; lymph node; ; rectum;
	Top expressed in
	right kidney; ; islet of Langerhans; ; primary oocyte; ; human kidney; ; proximal tubule; ; morula; ; morula; ; blastocyst; ; secondary oocyte; ; intestinal villus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	molecular function;
Cellular component	membrane; integral component of membrane; extracellular exosome;
Biological process	biological process;
	Sources:Amigo / QuickGO
Orthologs
	338094
	230579
	ENSG00000162391
	ENSMUSG00000034871
	Q8WW52
	Q8QZW3
	NM_176782
	NM_146149
	NP_788954
	NP_666261
	Wikidata
View/Edit Human	View/Edit Mouse

Family with sequence similarity 151 member A (abbreviated FAM151A) is a protein that in humans is encoded by the FAM151A gene. The protein is a transmembrane protein expressed in the kidney tubules, and is an ortholog of menorin, a protein involved in neuron development in nematodes.^[5]^[6]

Gene

The FAM151A gene contains 8 exons and is located on the minus strand of chromosome 1 at 1p32.3, spanning approximately 14 kbp.^[7]^[8] The last exon contains approximately half of the coding sequence, and overlaps with the 3' UTR of gene ACOT11.^[9] No alternative splicings of FAM151A are known.

Expression

The mRNA transcript of FAM151A is expressed in the kidney, small intestine, and liver, while the FAM151A protein is only expressed in kidney tubules.^[10]

Protein

The FAM151A protein contains three known domains, one transmembrane domain and two domains of unknown function DUF2181.^[11] DUF2181 is a member of the GDPD/PLCD superfamily, which are known to hydrolyze glycerophosphodiester bonds.^[12] The second DUF2181 of FAM151A is hypothesized to be nonfunctional through homology analysis. The molecular weight of FAM151A is known to be approximately 95 kDa.^[13]

Evolutionary history

Orthologs of FAM151A

FAM151A has direct orthologs in chimpanzee,^[14] mouse,^[15] zebrafish,^[16] and other members of the clade Eumetazoa that diverged from humans up to around 700 million years ago.^[17]^[18] However, FAM151A does not have any known orthologs in birds.

Protein family FAM151/Menorin

FAM151A has one known paralog in humans, FAM151B, which contains only the first DUF2181 and no transmembrane region.^[19] In mammals, both FAM151A and FAM151B are homologs of the C. elegans menorin gene, involved in dendrite branching.^[12]^[6]

Clinical significance

FAM151A contains an SNP, rs11206394, that is a significant predictor of colorectal cancer. The SNP is a missense mutation that occurs in the region of the second DUF2181 of FAM151A that overlaps with the 3' UTR of ACOT11. Individuals with both copies of the minor allele have been observed to have the odds of cancer decreased between 11% and 59%.^[20]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162391 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034871 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Prunotto, Marco; Farina, Annarita; Lane, Lydie; Pernin, Agnès; Schifferli, Jürg; Hochstrasser, Denis F.; Lescuyer, Pierre; Moll, Solange (2013-04-26). "Proteomic analysis of podocyte exosome-enriched fraction from normal human urine". Journal of Proteomics. 82: 193–229. doi:10.1016/j.jprot.2013.01.012. ISSN 1874-3919. PMID 23376485.
^ ^a ^b Ziegenfuss, Jennifer S.; Grueber, Wesley B. (2013-10-10). "SAX-7 and Menorin Light the Path for Dendrite Morphogenesis". Cell. 155 (2): 269–271. doi:10.1016/j.cell.2013.09.029. ISSN 0092-8674. PMID 24120127. S2CID 18210067.
^ "Homo sapiens family with sequence similarity 151 member A (FAM151A), m - Nucleotide - NCBI". 16 February 2021.
^ "Genecards Entry on FAM151A".
^ ^a ^b "NCBI Gene Entry on FAM151A".
^ "Human Protein Atlas entry on FAM151A".
^ "protein FAM151A [Homo sapiens] - Protein - NCBI".
^ ^a ^b Findlay, Amy S.; McKie, Lisa; Keighren, Margaret; Clementson-Mobbs, Sharon; Sanchez-Pulido, Luis; Wells, Sara; Cross, Sally H.; Jackson, Ian J. (2020-01-16). "Fam151b, the mouse homologue of C.elegans menorin gene, is essential for retinal function". Scientific Reports. 10 (1): 437. Bibcode:2020NatSR..10..437F. doi:10.1038/s41598-019-57398-4. ISSN 2045-2322. PMC 6965129. PMID 31949211.
^ "FAM151A Antibody (PA5-53502)". www.thermofisher.com. Retrieved 2021-12-18.
^ "NCBI protein entry on FAM151A [Pan troglodytes]".
^ "NCBI protein entry on FAM151A [Mus musculus]".
^ "NCBI protein entry on FAM151A [Danio rerio]".
^ "NCBI protein entry on FAM151A [Lingula anatina]".
^ "TimeTree :: The Timescale of Life". www.timetree.org. Retrieved 2021-10-24.
^ "NCBI Protein Entry on FAM151B".
^ Kang BW, Jeon HS, Chae YS, Lee SJ, Park JS, Choi GS, Kim JG (July 2016). "Impact of Genetic Variation in MicroRNA-binding Site on Susceptibility to Colorectal Cancer". Anticancer Res. 36 (7): 3353–61. PMID 27354594.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162391 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034871 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Prunotto, Marco; Farina, Annarita; Lane, Lydie; Pernin, Agnès; Schifferli, Jürg; Hochstrasser, Denis F.; Lescuyer, Pierre; Moll, Solange (2013-04-26). "Proteomic analysis of podocyte exosome-enriched fraction from normal human urine". Journal of Proteomics. 82: 193–229. doi:10.1016/j.jprot.2013.01.012. ISSN 1874-3919. PMID 23376485.

[:2-6] Ziegenfuss, Jennifer S.; Grueber, Wesley B. (2013-10-10). "SAX-7 and Menorin Light the Path for Dendrite Morphogenesis". Cell. 155 (2): 269–271. doi:10.1016/j.cell.2013.09.029. ISSN 0092-8674. PMID 24120127. S2CID 18210067.

[7] "Homo sapiens family with sequence similarity 151 member A (FAM151A), m - Nucleotide - NCBI". 16 February 2021.

[8] "Genecards Entry on FAM151A".

[:1-9] "NCBI Gene Entry on FAM151A".

[10] "Human Protein Atlas entry on FAM151A".

[11] "protein FAM151A [Homo sapiens] - Protein - NCBI".

[:0-12] Findlay, Amy S.; McKie, Lisa; Keighren, Margaret; Clementson-Mobbs, Sharon; Sanchez-Pulido, Luis; Wells, Sara; Cross, Sally H.; Jackson, Ian J. (2020-01-16). "Fam151b, the mouse homologue of C.elegans menorin gene, is essential for retinal function". Scientific Reports. 10 (1): 437. Bibcode:2020NatSR..10..437F. doi:10.1038/s41598-019-57398-4. ISSN 2045-2322. PMC 6965129. PMID 31949211.

[13] "FAM151A Antibody (PA5-53502)". www.thermofisher.com. Retrieved 2021-12-18.

[14] "NCBI protein entry on FAM151A [Pan troglodytes]".

[15] "NCBI protein entry on FAM151A [Mus musculus]".

[16] "NCBI protein entry on FAM151A [Danio rerio]".

[17] "NCBI protein entry on FAM151A [Lingula anatina]".

[18] "TimeTree :: The Timescale of Life". www.timetree.org. Retrieved 2021-10-24.

[19] "NCBI Protein Entry on FAM151B".

[20] Kang BW, Jeon HS, Chae YS, Lee SJ, Park JS, Choi GS, Kim JG (July 2016). "Impact of Genetic Variation in MicroRNA-binding Site on Susceptibility to Colorectal Cancer". Anticancer Res. 36 (7): 3353–61. PMID 27354594.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]