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Evan Flatow

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Evan Flatow
Born (1956-03-21) March 21, 1956 (age 68)
New York City
NationalityAmerican
Alma materPrinceton University, Columbia University College of Physicians and Surgeons
Known forshoulder surgery, scientist, researcher
AwardsThe Neer Award for Excellence in Shoulder Research, American Shoulder and Elbow Surgeons, 1992, 1994, 1996, 2004

Lifetime Achievement Award, New York Chapter, Arthritis Foundation, 2009

Elected to College of Fellows, American Institute for Medical and Biological Engineering, 2010
Scientific career
Fieldsorthopaedic surgeon
InstitutionsPresident, Mount Sinai West

Evan Flatow (born March 21, 1956) is an American orthopaedic surgeon-scientist. As of 2023, he is President of Mount Sinai West (formerly Mount Sinai Roosevelt), part of the Mount Sinai Health System. He published more than 400 book chapters and peer-reviewed articles.[1][2] Flatow is indicated as principal or co-principal investigator for nine research grants and listed on six patents for influential shoulder implant systems.[3][4]

Before Flatow's appointment at Mount Sinai West, he served as the Bernard J. Lasker Professor and Chair of the Leni and Peter W. May Department of Orthopaedic Surgery at Icahn School of Medicine at Mount Sinai, where he established a basic science tendon research group in the Orthopaedic Research Laboratory, and he also served as Director of the Orthopaedic Surgery Service at Mount Sinai Hospital in New York City.[5] He was chosen by Castle Connolly as one of America's top doctors[6] and has won the American Shoulder and Elbow Surgeons' Neer Award, its highest honor, four times.[7][8] He is the President of the Board of Trustees of St. Hilda's & St. Hugh's, where he graduated in 1973.

Career

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Flatow graduated from Princeton University with an A.B. in biomedical sciences in 1977 after completing a 39-page long senior thesis titled "The Comparative Biochemistry of Microtubule Accessory Proteins."[9] He earned his medical degree from the Columbia University College of Physicians and Surgeons in 1981 and completed a surgical residency at St. Luke's-Roosevelt Hospital Center and an orthopaedic residency and fellowship at Columbia-Presbyterian Medical Center.[8]

In 1998, after 11 years on the faculty at Columbia University, Flatow joined the staff at Mount Sinai Hospital. He was Chair of Orthopaedics from 2005 until 2014, and then President of Mount Sinai West, a position he still holds as of 2023. In collaboration with Mount Sinai's Department of Anesthesiology, Flatow pioneered the use of regional blocks to diminish the need for general anesthesia in shoulder surgery.[5][8]

He held positions as Chair of the Trustees of the Journal of Shoulder and Elbow Surgery, and Chair of the Publications Committee and of the Council on Education of the American Academy of Orthopaedic Surgeons.[10][11] He also served as President of American Shoulder & Elbow Surgeons.[12]

Scientific contributions

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Grants

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As of 2023, Flatow was Principal Investigator (PI) or Co-Principal on 11 research grants. Partial list:

  • Orthopaedic Research and Education Foundation PI, Career Development Award, April, 1989, $100,000 over 2 years. Biomechanical investigations into shoulder joint surface anatomy and modes of articulation.
  • PI, National Institutes of Health/NIAMSD K-08 Clinician Investigator Award, April, 1994, Pathobiology of rotator cuff tendon injury.[13]
  • PI, Orthopaedic Research and Education Society, Prospective Clinical Research Grant, February, 1996. Surgical repair of the torn rotator cuff tendon: a prospective analysis of function, quality of life, costs and factors that affect these analyses.
  • PI, Aircast Foundation, Research Grant, December, 2001. Assessment of Damage Accumulation in Rat Tendons.
  • PI, National Institutes of Health/NIAMSD R01 “Tendon response to In Vivo Fatigue Damage”.
  • PI, August 2011 –June 2014, Co-Investigator June 2014 –July 2016, National Institutes of Health/NIAMSD R01 “Effect of tendon damage accumulation on healing and adaptation.”
  • Co-PI, National Institutes of Health/National Institute of Aging R01 August 2012 – April 2017 “Human stem cell progenitor cell aging and regeneration.”
  • Co-PI, National Institutes of Health/NIAMSD R13 2014 “New Frontiers in Tendon Research.”[14]
  • Co-PI, New York City Economic Development Corporation Grant to build a Comprehensive Center for Surgical Innovation, Awarded November 2022, $11.6M over 2 years.[15]

Patents

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Flatow co-developed humeral stem and glenoid socket designs and procedures for coated and uncoated shoulder replacements. The process requires minimal bone resection and as of 2023 is used globally[11] in total shoulder arthroplasty.[16][17] Patents include:

  • Orthopaedic implant having an articulating surface with a conforming and translational surface, (1997).[18]
  • Orthopaedic implant having an articulating surface with a conforming and translational surface, (1999).[19]
  • Clamp assembly for use with orthopaedic retractor frame assembly, (2000).[20]
  • Instrument for seating a prosthesis, (2000).[21]
  • Method and instruments for positioning humeral component during shoulder arthroplasty, (2010).[22]
  • Intervention for tendinopathy, (2020).[23]

Developments and implications

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Flatow focuses on minimally invasive fracture repair, arthroscopic rotator cuff surgery, arthroscopic repair and shoulder replacement.[24] Developments include:

Shoulder articular geometry and kinematics: Flatow contributed to the development of a glenoid implant with dual-curvatures allowing central conformity with low contact stress.[25]

Cadaver studies of rotator cuff tendon injury: demonstrated the effects of subacromial compression and tensile load on the supraspinatus tendon, with implications for clinical failure.[26][27][28]

Clinical outcome studies of rotator cuff tendon repair: rotator cuff tendon failure and repair, demonstration that cuff-tendon repair was a cost-effective procedure, that re-tears were common, and that muscle atrophy did not recover after tendon repair.[29]

Development of a rat infrapatellar tendon repetitive fatigue-damage model of tendon injury: collaborated to refine histologic and imaging techniques to assess tendon damage.[30][31][32]

Characterization of the mechanical and biologic response of tendon to repetitive fatigue damage, and the effect of exercise.Demonstrated that damage is permanent, apoptosis resulted, and fatigued tendon failed to mount a robust biologic and reparative response.[33][34][35]

Honors and awards

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  • Manfred Pyka Physics Prize, Princeton University, Princeton, New Jersey, June, 1974
  • Phi Beta Kappa, Princeton University, Princeton, New Jersey, June, 1977
  • Alumni Association Bronze Medal, College of Physicians and Surgeons Alumni Association, Columbia University, June, 1981
  • The Frank E. Stinchfield Award for Excellence in Orthopaedic Surgery, New York, 1985, 1986
  • Orthopaedic Hospital at Columbia-Presbyterian Medical Center, New York, New York, April, 1986
  • Career Development Award, Orthopaedic Research and Education Foundation, April, 1989
  • The Neer Award for Excellence in Shoulder Research, American Shoulder and Elbow Surgeons, 1992, 1994, 1996, 2004
  • Irving Scholar Award, College of Physicians and Surgeons, Columbia University, March, 1993
  • European Traveling Fellowship, American Shoulder and Elbow Surgeons, May, 1993
  • Clinician Investigator Award, National Institutes of Health/NIAMSD, April, 1994
  • American, British, Canadian Exchange Traveling Fellowship, American Orthopaedic Association, May, 1995
  • Lifetime Achievement Award, New York Chapter, Arthritis Foundation, 2009
  • Elected to College of Fellows, American Institute for Medical and Biological Engineering, 2010
  • Jacobi Medallion, Association of the Alumni of The Mount Sinai Hospital, 2021

Publications

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Flatow is a reviewer for Clinical Orthopaedics and Related Research, the Journal of Bone and Joint Surgery, Arthroscopy, the Journal of Orthopaedic Research, and the American Journal of Sports Medicine. He is the former North American editor and chair, board of trustees, for the Journal of Shoulder and Elbow Surgery. He is a reviewer for that journal as of 2022.

Books

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  • Shoulder Arthroplasty. Louis U. Bigliani, Evan L. Flatow (editors). Springer, 2005. ISBN 0-387-22336-3
  • The Rotator Cuff. Part I. The Orthopedic Clinics of North America. Evan L. Flatow (author). Saunders, 1997. ASIN B0019FV1QW
  • The Rotator Cuff. Part II. The Orthopedic Clinics of North America. Evan L. Flatow (author). Saunders, 1997. ASIN B0018OPBX8
  • Humerus (Musculoskeletal Trauma Series). Evan L. Flatow, Christoph Ulrich (authors); Evan L. Flatow (editor). Butterworth-Heinemann, 1997. ISBN 0-7506-0840-4
  • The Unstable Shoulder. Louis U. Bigliani, Robert A. Arciero, Evan L. Flatow, Roger G. Pollock, James E. Tibone, Jon J. P. Warner (editors). Amer Acad of Orthopaedic Surgeons, 1996. ISBN 0-89203-120-4
  • Complex and Revision Problems in Shoulder Surgery. Jon JP Warner, Joseph P Iannotti, Evan L Flatow (editors). Lippincott Williams & Wilkins, 2005. ISBN 0-7817-4658-2
  • Atlas of Essential Orthopaedic Procedures, Second Edition, Evan L. Flatow, Alexis C. Colvin, Wolters Kluwer Health, 2019. ISBN 9781975124878

Peer reviewed publications

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As of 2023, Flatow was cited 22,600 times, has an h-index of 81and an i10-index of 194.[36]

Highest cited (partial list):

  • Gladstone JN, Bishop JY, Lo IKY, Flatow EL. Fatty Infiltration and Atrophy of the Rotator Cuff do not Improve after Rotator Cuff Repair and Correlate with Poor Functional Outcome. The American Journal of Sports Medicine. 2007;35(5):719-728. doi:10.1177/0363546506297539 Citations: 930[37]
  • Bigliani LU, Pollock RG, Soslowsky LJ, Flatow EL, Pawluk RJ, Mow VC. Tensile properties of the inferior glenohumeral ligament. J Orthop Res. 1992 Mar;10(2):187-97. doi: 10.1002/jor.1100100205. PMID 1740736. Citations: 735
  • Bishop J, Klepps S, Lo IK, Bird J, Gladstone JN, Flatow EL. Cuff integrity after arthroscopic versus open rotator cuff repair: a prospective study. J Shoulder Elbow Surg. 2006 May-Jun;15(3):290-9. doi: 10.1016/j.jse.2005.09.017. PMID 16679227. Citations: 668
  • Bigliani LU, Ticker JB, Flatow EL, Soslowsky LJ, Mow VC. The relationship of acromial architecture to rotator cuff disease. Clinics in Sports Medicine. 1991 Oct;10(4):823-838. PMID 1934099. Citations: 619
  • Flatow EL, Soslowsky LJ, Ticker JB, et al. Excursion of the Rotator Cuff Under the Acromion: Patterns of Subacromial Contact. The American Journal of Sports Medicine. 1994;22(6):779-788. doi:10.1177/036354659402200609 Citations: 481[38]

Most recent:

  • Duey, Akiro & Li, Troy & White, Christopher & Patel, Akshar & Cirino, Carl & Parsons, Bradford & Flatow, Evan & Cagle, Paul. (2023). A comparison of pegged and keeled glenoid clinical outcomes at long-term follow-up after total shoulder arthroplasty. Journal of Orthopaedics. 36. 10.1016/j.jor.2023.01.006. PMID 36710938
  • White, Christopher & Patel, Akshar & Wang, Kevin & Cirino, Carl & Parsons, Bradford & Flatow, Evan & Cagle, Paul. (2023). The impact of tobacco use on clinical outcomes and long-term survivorship after anatomic total shoulder arthroplasty. Journal of Orthopaedics. 36. 10.1016/j.jor.2023.01.002. PMID 36659901
  • White, Christopher & Duey, Akiro & Parsons, Bradford & Flatow, Evan & Cagle, Paul. (2023). Anatomic Total Shoulder Arthroplasty Outcomes and Implant Survivability at Greater Than 22 Years Postoperative Follow-up: A Case Series. Journal of Orthopaedic Reports. 2. 100129. 10.1016/j.jorep.2022.100129.[39]
  • White, Christopher & Patel, Akshar & Cirino, Carl & Wang, Kevin & Gross, Benjamin & Parsons, Bradford & Flatow, Evan & Cagle, Paul. (2022). Does Body Mass Index Influence Long-Term Outcomes After Anatomic Total Shoulder Arthroplasty?. Journal of Shoulder and Elbow Surgery. 10.1016/j.jse.2022.10.032. PMID 36464204
  • Wang, Kevin & Kantrowitz, David & Patel, Akshar & Parsons, Bradford & Flatow, Evan & Cagle, Paul. (2022). Survivorship of Total Shoulder Arthroplasty versus Hemiarthroplasty for the Treatment of Avascular Necrosis at Greater than 10-Year Follow-up. Journal of shoulder and elbow surgery. 31. 10.1016/j.jse.2022.02.019. PMID 35339708

References

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  1. ^ "Flatow EL - Search Results - PubMed". PubMed. Retrieved 2022-01-26.
  2. ^ "Evan Flatow". scholar.google.com. Retrieved 2023-02-12.
  3. ^ "A century of shoulder arthroplasty innovations and discoveries". www.healio.com. Retrieved 2022-02-04.
  4. ^ Flatow, E.; Harrison, A. (2011). "A History of Reverse Total Shoulder Arthroplasty". Clinical Orthopaedics and Related Research. 469 (9): 2432–2439. doi:10.1007/s11999-010-1733-6. PMC 3148354. PMID 21213090. S2CID 33062066.
  5. ^ a b "Mount Sinai Hospital – Doctor profile". Mount Sinai Hospital.
  6. ^ "Castle Connolly Medical Ltd". Archived from the original on June 30, 2009. Retrieved January 17, 2010.
  7. ^ "American Shoulder and Elbow Surgeons". Becker's Hospital Review. Archived from the original on October 22, 2007. Retrieved January 17, 2010.
  8. ^ a b c "Ten Shoulder Specialists to Know: Becker's Hospital Review". Archived from the original on June 30, 2009. Retrieved January 17, 2010.
  9. ^ Flatow, Evan Lloyd (1977). "The Comparative Biochemistry of Microtubule Accessory Proteins". {{cite journal}}: Cite journal requires |journal= (help)
  10. ^ "AAOS Media Center". www.aaos-annualmeeting-presskit.org. Retrieved 2023-02-13.
  11. ^ a b "LEADERS Interview with Evan L. Flatow, MD, President, Mount Sinai West". www.leadersmag.com. Retrieved 2023-02-13.
  12. ^ "The Top 28 North American Shoulder Surgeons" (PDF). Orthopedics This Week. September 24, 2013. Retrieved February 12, 2023.
  13. ^ Blevins, F. T.; Djurasovic, M.; Flatow, E. L.; Vogel, K. G. (1997). "Biology of the rotator cuff tendon". The Orthopedic Clinics of North America. 28 (1): 1–16. doi:10.1016/s0030-5898(05)70260-1. ISSN 0030-5898. PMID 9024427.
  14. ^ "RePORT ⟩ RePORTER". reporter.nih.gov. Retrieved 2023-02-13.
  15. ^ Klein, Kristine (2022-08-25). "NYCEDC announces $26.6 million grant for two new life sciences facilities". The Architect’s Newspaper. Retrieved 2023-02-12.
  16. ^ Godenèche, Arnaud; Garret, Jérôme; Barth, Johannes; Michelet, Aude; Geais, Laurent (2019-02-20). "Comparison of revision rates and radiographic observations of long and short, uncoated and coated humeral stem designs in total shoulder arthroplasty". EFORT Open Reviews. 4 (2): 70–76. doi:10.1302/2058-5241.4.180046. ISSN 2058-5241. PMC 6404789. PMID 30931151.
  17. ^ David M. Levy, MD, Joshua A. Metzl, MD, G. Christian Vorys, MD, William N. Levine, MD, Christopher S. Ahmad, MD, and Louis U. Bigliani, MD. "Clinical and Radiographic Outcomes of Total Shoulder Arthroplasty With a Hybrid Dual-Radii Glenoid Component" (PDF). American Journal of Orthopedics. Retrieved February 15, 2023.{{cite web}}: CS1 maint: multiple names: authors list (link)
  18. ^ US 5928285, Bigliani, Louis U.; Flatow, Evan L. & Norman, Delfreda L., "Orthopaedic implant having an articulating surface with a conforming and translational surface", published 1999-07-27, assigned to Bristol-Meyers Squibb Co. 
  19. ^ US 5928285, Bigliani, Louis U.; Flatow, Evan L. & Norman, Delfreda L., "Orthopaedic implant having an articulating surface with a conforming and translational surface", published 1999-07-27, assigned to Bristol-Meyers Squibb Co. 
  20. ^ US 6017306, Bigliani, Louis U.; Flatow, Evan L. & Norman, Delfreda L. et al., "Clamp assembly for use with orthopaedic retractor frame assembly", published 2000-01-25, assigned to Bristol-Meyers Squibb Co. 
  21. ^ US 6120507, Allard, Randall N.; Willard, David B. & Flatow, Evan L., "Instrument and method for seating prosthesis", published 2000-09-19, assigned to Bristol-Meyers Squibb Co. 
  22. ^ US 7699853, Durand-Allen, Anitra; Wiley, Roy & Bigliani, Louis et al., "Method and instruments for positioning humeral component during shoulder arthroplasty", published 2010-04-20, assigned to Zimmer Inc. 
  23. ^ US 10874748, Sun, Hui B.; Flatow, Evan L. & Wanich, Tony et al., "Intervention for tendinopathy", published 2020-12-29, assigned to Albert Einstein College of Medicine, and Icahn School of Medicine at Mount Sinai & Montefiore Medical Center 
  24. ^ Keenan, John (2018-06-06). "Orthopaedic resident graduation events Friday". Newsroom. Retrieved 2023-02-12.
  25. ^ Ehresmann, K R; Mills, W A; Loewenson, P R; Moore, K A (2000). "Attitudes and practices regarding varicella vaccination among physicians in Minnesota: implications for public health and provider education". American Journal of Public Health. 90 (12): 1917–1920. doi:10.2105/ajph.90.12.1917. ISSN 0090-0036. PMC 1446435. PMID 11111266.
  26. ^ Flatow, E. L.; Soslowsky, L. J.; Ticker, J. B.; Pawluk, R. J.; Hepler, M.; Ark, J.; Mow, V. C.; Bigliani, L. U. (1994). "Excursion of the rotator cuff under the acromion. Patterns of subacromial contact". The American Journal of Sports Medicine. 22 (6): 779–788. doi:10.1177/036354659402200609. hdl:2027.42/67283. ISSN 0363-5465. PMID 7856802. S2CID 11577634.
  27. ^ Huang, Chun-Yuh; Wang, Vincent M.; Pawluk, Robert J.; Bucchieri, John S.; Levine, William N.; Bigliani, Louis U.; Mow, Van C.; Flatow, Evan L. (2005). "Inhomogeneous mechanical behavior of the human supraspinatus tendon under uniaxial loading". Journal of Orthopaedic Research. 23 (4): 924–930. doi:10.1016/j.orthres.2004.02.016. ISSN 0736-0266. PMID 16023009. S2CID 12121653.
  28. ^ Huang, Chun-Yuh; Wang, Vincent M.; Flatow, Evan L.; Mow, Van C. (2009-03-11). "Temperature-dependent viscoelastic properties of the human supraspinatus tendon". Journal of Biomechanics. 42 (4): 546–549. doi:10.1016/j.jbiomech.2008.11.013. ISSN 1873-2380. PMC 2684675. PMID 19159888.
  29. ^ Bishop, Julie; Klepps, Steven; Lo, Ian K.; Bird, Justin; Gladstone, James N.; Flatow, Evan L. (2006). "Cuff integrity after arthroscopic versus open rotator cuff repair: a prospective study". Journal of Shoulder and Elbow Surgery. 15 (3): 290–299. doi:10.1016/j.jse.2005.09.017. ISSN 1058-2746. PMID 16679227.
  30. ^ Laudier, Damien; Schaffler, Mitchell B.; Flatow, Evan L.; Wang, Vincent M. (2007). "Novel procedure for high-fidelity tendon histology". Journal of Orthopaedic Research. 25 (3): 390–395. doi:10.1002/jor.20304. ISSN 0736-0266. PMID 17149746. S2CID 21816985.
  31. ^ Fung, David T.; Wang, Vincent M.; Andarawis-Puri, Nelly; Basta-Pljakic, Jelena; Li, Yonghui; Laudier, Damien M.; Sun, Hui B.; Jepsen, Karl J.; Schaffler, Mitchell B.; Flatow, Evan L. (2010-01-19). "Early response to tendon fatigue damage accumulation in a novel in vivo model". Journal of Biomechanics. 43 (2): 274–279. doi:10.1016/j.jbiomech.2009.08.039. ISSN 1873-2380. PMC 3366582. PMID 19939387.
  32. ^ Fung, David T.; Sereysky, Jedd B.; Basta-Pljakic, Jelena; Laudier, Damien M.; Huq, Rumana; Jepsen, Karl J.; Schaffler, Mitchell B.; Flatow, Evan L. (2010). "Second harmonic generation imaging and Fourier transform spectral analysis reveal damage in fatigue-loaded tendons". Annals of Biomedical Engineering. 38 (5): 1741–1751. doi:10.1007/s10439-010-9976-7. ISSN 1573-9686. PMC 4785269. PMID 20232150.
  33. ^ Sun, Hui B.; Andarawis-Puri, Nelly; Li, Yonghui; Fung, David T.; Lee, Jonathan Y.; Wang, Vincent M.; Basta-Pljakic, Jelena; Leong, Daniel J.; Sereysky, Jedd B.; Ros, Stephen J.; Klug, Raymond A. (2010). "Cycle-dependent matrix remodeling gene expression response in fatigue-loaded rat patellar tendons". Journal of Orthopaedic Research. 28 (10): 1380–1386. doi:10.1002/jor.21132. ISSN 1554-527X. PMC 4408775. PMID 20839322.
  34. ^ Andarawis-Puri, Nelly; Sereysky, Jedd B.; Jepsen, Karl J.; Flatow, Evan L. (2012-01-03). "The relationships between cyclic fatigue loading, changes in initial mechanical properties, and the in vivo temporal mechanical response of the rat patellar tendon". Journal of Biomechanics. 45 (1): 59–65. doi:10.1016/j.jbiomech.2011.10.008. ISSN 1873-2380. PMC 3763928. PMID 22055428.
  35. ^ Andarawis-Puri, Nelly; Philip, Anaya; Laudier, Damien; Schaffler, Mitchell B.; Flatow, Evan L. (2014). "Temporal effect of in vivo tendon fatigue loading on the apoptotic response explained in the context of number of fatigue loading cycles and initial damage parameters". Journal of Orthopaedic Research. 32 (9): 1097–1103. doi:10.1002/jor.22639. ISSN 1554-527X. PMC 4209741. PMID 24838769.
  36. ^ "Evan Flatow". scholar.google.com. Retrieved 2022-01-26.
  37. ^ "Fatty infiltration and atrophy of the rotator cuff do not improve after rotator cuff repair and correlate with poor functional outcome". scholar.google.com. Retrieved 2023-02-13.
  38. ^ "Excursion of the rotator cuff under the acromion: patterns of subacromial contact". scholar.google.com. Retrieved 2023-02-13.
  39. ^ White, Christopher A.; Duey, Akiro; Parsons, Bradford O.; Flatow, Evan L.; Cagle, Paul J. (2023-06-01). "Anatomic total shoulder arthroplasty outcomes and implant survivability at greater than 22 years postoperative follow-up: A case series". Journal of Orthopaedic Reports. 2 (2): 100129. doi:10.1016/j.jorep.2022.100129. ISSN 2773-157X. S2CID 255636585.
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