Estrone phosphate
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Other names | Estrone 3-phosphate; E1P; O3-Phosphonoestrone; 17-Oxoestra-1,3,5(10)-trien-3-yl dihydrogen phosphate |
Drug class | Estrogen; Steroid sulfatase inhibitor |
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Formula | C18H23O5P |
Molar mass | 350.351 g·mol−1 |
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Estrone phosphate (E1P), or estrone 3-phosphate, is an estrogen and steroid sulfatase inhibitor which was never marketed.[1][2][3] It has similar affinity for steroid sulfatase as estrone sulfate and acts as a competitive inhibitor of the enzyme.[2][3][4] In contrast to estrone sulfate however, it is not hydrolyzed by steroid sulfatase and is instead metabolized by phosphatases.[1][2][3]
See also
[edit]References
[edit]- ^ a b Bourne GH (May 1954). "The histochemical dephosphorylation of oestrogen phosphates". The Journal of Physiology. 124 (2): 409–416. doi:10.1113/jphysiol.1954.sp005117. PMC 1366276. PMID 13175141.
- ^ a b c Li PK, Pillai R, Dibbelt L (March 1995). "Estrone sulfate analogs as estrone sulfatase inhibitors". Steroids. 60 (3): 299–306. doi:10.1016/0039-128x(94)00048-h. PMID 7792836. S2CID 3070641.
- ^ a b c Anderson CJ, Lucas LJ, Widlanski TS (1995). "Molecular Recognition in Biological Systems: Phosphate Esters vs Sulfate Esters and the Mechanism of Action of Steroid Sulfatases". Journal of the American Chemical Society. 117 (13): 3889–3890. doi:10.1021/ja00118a034. ISSN 0002-7863.
- ^ Phan CM, Liu Y, Kim BM, Mostafa Y, Taylor SD (October 2011). "Inhibition of steroid sulfatase with 4-substituted estrone and estradiol derivatives". Bioorganic & Medicinal Chemistry. 19 (20): 5999–6005. doi:10.1016/j.bmc.2011.08.046. PMID 21925885.