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Ervin Fodor

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Ervin Fodor is a British virologist of Hungarian origin born in Czechoslovakia. He is Professor of Virology holding the position of reader in experimental pathology in the Sir William Dunn School of Pathology at the University of Oxford. He is also a professorial fellow at Exeter College, Oxford.

Education

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Fodor has an MSc in Chemical Engineering (Slovak University of Technology in Bratislava) and a DPhil in Pathology (University of Oxford).[1][2]

Career

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After postdoctoral studies at the Icahn School of Medicine at Mount Sinai New York and the Sir William Dunn School of Pathology at the University of Oxford, Fodor has been awarded a MRC Senior Non-Clinical Research Fellowship in 2002 followed by a RCUK Academic Fellowship in 2008.[2]

He was appointed as university lecturer in 2011 and then as reader at the University of Oxford with the title of professor of virology.[2]

Fodor's research focuses on the molecular biology of influenza viruses.[3][4][5] An early highlight of his work was the development of a reverse genetics system to generate recombinant influenza viruses following plasmid transfection.[6] This technology, developed in collaboration with Peter Palese and Adolfo García-Sastre at the Icahn School of Medicine and George Brownlee at the University of Oxford, was then used to generate live attenuated influenza virus vaccines that are also used in the UK National Childhood Flu Immunisation Programme.[7] His more recent work focuses on the molecular mechanisms used by influenza viruses to copy their genetic information stored in molecules of RNA, interactions of influenza viruses with the host cell and cellular responses to viral infection.[8][9][10] In collaboration with Jonathan Grimes from the Division of Structural Biology at the University of Oxford he contributed to understanding the structural basis of influenza virus RNA synthesis by solving structures of the influenza virus RNA polymerase complex.[11][12][13][14]

He is the recipient of the 2019 AstraZeneca Award from the Biochemical Society.[15] The award was presented on 20–22 November 2019 in London, UK[16] at the meeting of the Biochemical Society entitled‘Transcriptions in Health and Disease’ where Fodor delivered a lecture entitled 'The influenza virus RNA polymerase'.

Fodor is a fellow of the Academy of Medical Sciences[17] and was elected as a member of EMBO in 2021.[18][19]

References

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  1. ^ "ORCID". orcid.org. Retrieved 12 November 2021.
  2. ^ a b c "Professor Ervin Fodor". Exeter College. Retrieved 25 January 2023.
  3. ^ Te Velthuis, Aartjan J. W.; Fodor, Ervin (August 2016). "Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis". Nature Reviews. Microbiology. 14 (8): 479–493. doi:10.1038/nrmicro.2016.87. ISSN 1740-1534. PMC 4966622. PMID 27396566.
  4. ^ Te Velthuis, Aartjan J. W.; Grimes, Jonathan M.; Fodor, Ervin (May 2021). "Structural insights into RNA polymerases of negative-sense RNA viruses". Nature Reviews. Microbiology. 19 (5): 303–318. doi:10.1038/s41579-020-00501-8. ISSN 1740-1534. PMC 7832423. PMID 33495561.
  5. ^ "Ervin Fodor : Influenza virus replication at the molecular level". University of Oxford Medical Sciences Division. Retrieved 25 January 2023.
  6. ^ Fodor, E.; Devenish, L.; Engelhardt, O. G.; Palese, P.; Brownlee, G. G.; García-Sastre, A. (November 1999). "Rescue of influenza A virus from recombinant DNA". Journal of Virology. 73 (11): 9679–9682. doi:10.1128/JVI.73.11.9679-9682.1999. ISSN 0022-538X. PMC 113010. PMID 10516084.
  7. ^ "REF Case study search". impact.ref.ac.uk. Retrieved 12 November 2021.
  8. ^ Te Velthuis, Aartjan J. W.; Robb, Nicole C.; Kapanidis, Achillefs N.; Fodor, Ervin (21 March 2016). "The role of the priming loop in influenza A virus RNA synthesis". Nature Microbiology. 1 (5): 16029. doi:10.1038/nmicrobiol.2016.29. ISSN 2058-5276. PMC 4888940. PMID 27572643.
  9. ^ Te Velthuis, Aartjan J. W.; Long, Joshua C.; Bauer, David L. V.; Fan, Rebecca L. Y.; Yen, Hui-Ling; Sharps, Jane; Siegers, Jurre Y.; Killip, Marian J.; French, Hollie; Oliva-Martín, Maria José; Randall, Richard E. (November 2018). "Mini viral RNAs act as innate immune agonists during influenza virus infection". Nature Microbiology. 3 (11): 1234–1242. doi:10.1038/s41564-018-0240-5. ISSN 2058-5276. PMC 6203953. PMID 30224800.
  10. ^ Dadonaite, Bernadeta; Gilbertson, Brad; Knight, Michael L.; Trifkovic, Sanja; Rockman, Steven; Laederach, Alain; Brown, Lorena E.; Fodor, Ervin; Bauer, David L. V. (November 2019). "The structure of the influenza A virus genome". Nature Microbiology. 4 (11): 1781–1789. doi:10.1038/s41564-019-0513-7. ISSN 2058-5276. PMC 7191640. PMID 31332385.
  11. ^ Hengrung, Narin; El Omari, Kamel; Serna Martin, Itziar; Vreede, Frank T.; Cusack, Stephen; Rambo, Robert P.; Vonrhein, Clemens; Bricogne, Gérard; Stuart, David I.; Grimes, Jonathan M.; Fodor, Ervin (26 October 2015). "Crystal structure of the RNA-dependent RNA polymerase from influenza C virus". Nature. 527 (7576): 114–117. Bibcode:2015Natur.527..114H. doi:10.1038/nature15525. ISSN 0028-0836. PMC 4783868. PMID 26503046.
  12. ^ Serna Martin, Itziar; Hengrung, Narin; Renner, Max; Sharps, Jane; Martínez-Alonso, Mónica; Masiulis, Simonas; Grimes, Jonathan M.; Fodor, Ervin (18 October 2018). "A Mechanism for the Activation of the Influenza Virus Transcriptase". Molecular Cell. 72 (2): 396. doi:10.1016/j.molcel.2018.10.005. ISSN 1097-4164. PMC 6201736. PMID 30340026.
  13. ^ Fan, Haitian; Walker, Alexander P.; Carrique, Loïc; Keown, Jeremy R.; Serna Martin, Itziar; Karia, Dimple; Sharps, Jane; Hengrung, Narin; Pardon, Els; Steyaert, Jan; Grimes, Jonathan M. (September 2019). "Structures of influenza A virus RNA polymerase offer insight into viral genome replication". Nature. 573 (7773): 287–290. Bibcode:2019Natur.573..287F. doi:10.1038/s41586-019-1530-7. ISSN 1476-4687. PMC 6795553. PMID 31485076.
  14. ^ Carrique, Loïc; Fan, Haitian; Walker, Alexander P.; Keown, Jeremy R.; Sharps, Jane; Staller, Ecco; Barclay, Wendy S.; Fodor, Ervin; Grimes, Jonathan M. (November 2020). "Host ANP32A mediates the assembly of the influenza virus replicase". Nature. 587 (7835): 638–643. Bibcode:2020Natur.587..638C. doi:10.1038/s41586-020-2927-z. ISSN 1476-4687. PMC 7116770. PMID 33208942.
  15. ^ "Ervin Fodor honoured with the 2019 AstraZeneca Award | Sir William Dunn School of Pathology". www.path.ox.ac.uk. Retrieved 25 May 2021.
  16. ^ "The AstraZeneca Award". Biochemistry. Retrieved 25 May 2021.
  17. ^ "Professor Ervin Fodor is Elected Fellow of the Academy of Medical Sciences | Sir William Dunn School of Pathology". www.path.ox.ac.uk. Retrieved 25 May 2021.
  18. ^ "Professor Ervin Fodor Elected as Member of EMBO | Sir William Dunn School of Pathology". www.path.ox.ac.uk. Retrieved 12 November 2021.
  19. ^ "EMBO announces 64 newly elected members – Press releases – EMBO". 8 June 2021. Retrieved 12 November 2021.
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