Epsilon antitoxin
| Bacterial epsilon antitoxin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of the plasmid maintenance system epsilon/zeta: meachnism of toxin inactivation and toxin function | |||||||||
| Identifiers | |||||||||
| Symbol | Epsilon_antitox | ||||||||
| Pfam | PF08998 | ||||||||
| InterPro | IPR015090 | ||||||||
| |||||||||
In molecular biology, the epsilon antitoxin, produced by various prokaryotes, forms part of a post-segregational killing system, which is involved in the initiation of programmed cell death of plasmid-free cells. The protein is folded into a three-helix bundle that directly interacts with the zeta toxin, inactivating it.[1]
References
[edit]- ^ Meinhart A, Alonso JC, Strater N, Saenger W (February 2003). "Crystal structure of the plasmid maintenance system epsilon/zeta: functional mechanism of toxin zeta and inactivation by epsilon 2 zeta 2 complex formation". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1661–6. doi:10.1073/pnas.0434325100. PMC 149889. PMID 12571357.