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Gastroenterology

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Gastroenterology
Illustration of the digestive system
SystemGastrointestinal
Significant diseasesGastrointestinal cancers, Gastrointestinal bleeding, Liver cirrhosis, Gallstones, Gastroenteritis, Inflammatory bowel disease
Significant testsColonoscopy, Stool test, Barium swallows, Endoscopy
SpecialistGastroenterologist
GlossaryGlossary of medicine
Gastroenterologist
Occupation
Names
  • Physician
Occupation type
Specialty
Activity sectors
Medicine
Description
Education required
Fields of
employment
Hospitals, Clinics

Gastroenterology (from the Greek gastḗr- "belly", -énteron "intestine", and -logía "study of") is the branch of medicine focused on the digestive system and its disorders.[1] The digestive system consists of the gastrointestinal tract, sometimes referred to as the GI tract, which includes the esophagus, stomach, small intestine and large intestine as well as the accessory organs of digestion which include the pancreas, gallbladder, and liver.[2][3]

The digestive system functions to move material through the GI tract via peristalsis, break down that material via digestion, absorb nutrients for use throughout the body, and remove waste from the body via defecation.[3] Physicians who specialize in the medical specialty of gastroenterology are called gastroenterologists or sometimes GI doctors.

Some of the most common conditions managed by gastroenterologists include gastroesophageal reflux disease, gastrointestinal bleeding, irritable bowel syndrome, inflammatory bowel disease (IBD) which includes Crohn's disease and ulcerative colitis, peptic ulcer disease, gallbladder and biliary tract disease, hepatitis, pancreatitis, colitis, colon polyps and cancer, nutritional problems, and many more.[4]

History

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Drawings of Bozzini's "Lichtleiter", an early endoscope

Citing from Egyptian papyri, John F. Nunn identified significant knowledge of gastrointestinal diseases among practicing physicians during the periods of the pharaohs. Irynakhty, of the tenth dynasty, c. 2125 B.C., was a court physician specializing in gastroenterology, sleeping, and proctology.[5]

Among ancient Greeks, Hippocrates attributed digestion to concoction. Galen's concept of the stomach having four faculties was widely accepted up to modernity in the seventeenth century.[6]

18th century

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19th century

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McClendon's pH-probe

20th century

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21st century

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Disease classification

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1. International Classification of Disease (ICD 2007)/WHO classification:

  • Chapter XI, Diseases of the digestive system,(K00-K93)

2. MeSH subject Heading:

  • Gastroenterology (G02.403.776.409.405)
  • Gastroenterological diseases(C06.405)

3. National Library of Medicine Catalogue (NLM classification 2006):

Procedures

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Colonoscopy

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See also: Colonoscopy
Diagram of a colonoscopy procedure

A procedure using a long thin tube with a camera that is passed through the anus to visualize the rectum and the entire length of the colon. The procedure is performed either to look for colon polyps and/or colon cancer in somebody without symptoms, referred to as screening, or to further evaluate symptoms including rectal bleeding, dark tarry stools, change in bowel habits or stool consistency (diarrhea, pencil-thin stool), abdominal pain, and unexplained weight loss. Before the procedure, the physician might ask the patient to stop taking certain medications including blood thinners, aspirin, diabetes medications, or nonsteroidal anti-inflammatory drugs. A bowel prep is usually taken the night before and into the morning of the procedure which consists of an enema or laxatives, either pills or powder dissolved in liquid, that will cause diarrhea. The procedure might need to be stopped and rescheduled if there is stool remaining in the colon due to an incomplete bowel prep because the physician can not adequately visualize the colon. During the procedure, the patient is sedated and the scope is used to examine the entire length of the colon looking for polyps, bleeding, or abnormal tissue. A biopsy or polyp removal can then be performed and the tissue sent to the lab for evaluation. The procedure usually takes thirty minutes to an hour followed by a one to two hour observation period. Complications include bloating, cramping, a reaction to anesthesia, bleeding, and a hole through the wall of the colon that may require repeat colonoscopy or surgery. Signs of a serious complication requiring urgent or emergent medical attention include severe pain in the abdomen, fever, bleeding that does not improve, dizziness, and weakness.[15]

Sigmoidoscopy

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See also: Sigmoidoscopy
Sigmoidoscopy

A procedure similar to a colonoscopy using a long thin tube with a camera (scope) passed through the anus but only intended to visualize the rectum and the last part of the colon closest to the rectum. All aspects of the procedure are the same as for a colonoscopy with the exception that this procedure only lasts ten to twenty minutes and is done without sedation. This usually allows for the patient to return to normal activities immediately after the procedure is finished.[16]

Esophagogastroduodenoscopy (EGD)

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See also: Esophagogastroduodenoscopy
Endoscopy

A procedure using a long thin tube with a camera that is passed through the mouth to view the esophagus ("esophago-"), stomach ("gastro-"), and the duodenum ("duodeno-"). It is also referred to as upper endoscopy or just endoscopy. The procedure is performed for further evaluation of symptoms including persistent heartburn, indigestion, vomiting blood, dark tarry stools, persistent nausea and vomiting, pain, difficulty swallowing, painful swallowing, and unexplained weight loss. It is also performed for further testing following a lab test that shows low hemoglobin levels without a known cause or an abnormal barium swallow. The procedure can be used to diagnose many disorders through direct visualization or tissue biopsy including esophageal varices, esophageal strictures, gastroesophageal reflux disease, Barrett's esophagus, cancer, celiac disease, gastritis, peptic ulcer disease, and a H. pylori infection. Intra-operative techniques can then be used for treatment of certain disorders like banding esophageal varices or dilating esophageal strictures. The patient will likely be required to not eat or drink anything starting 4 hours prior to the procedure. Sedation is usually required for patient comfort. This procedure usually lasts around thirty minutes followed by a one to two hour observation period. Side effects include bloating, nausea, and a sore throat for 1 to 2 days. Complications are rare but include reaction to the anesthesia, bleeding, and a hole through the wall of the esophagus, stomach, or small intestine which could require surgery. Signs of a serious complication requiring urgent or emergent medical attention include chest pain, problems breathing, problems swallowing, throat pain that gets worse, vomiting with blood or the appearance of "coffee-grounds", worsening abdominal pain, bloody or black tarry stool, and fever.[17]

Endoscopic Retrograde Cholangiopancreatography (ERCP)

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See also: Endoscopic retrograde cholangiopancreatography
ERCP

A procedure using a long thin tube with a camera passed through the mouth into the first part of the small intestine to locate, diagnose, and treat disorders related to the bile and pancreatic ducts. These ducts carry fluids that help with digesting food from the liver, gallbladder, and pancreas and can become narrowed or blocked as a result of gallstones, infection, inflammation, pancreatic pseudocysts, and tumors of the bile ducts or pancreas. As a result, one may experience back pain, yellowing of the skin, and an abnormal lab test showing an elevated bilirubin level which could necessitate this procedure. However, the procedure is not recommended if the patient has acute pancreatitis unless the level of bilirubin remains high or is increasing which could suggest the blockage is still present. The patient will likely be required to not eat or drink anything starting 8 hours prior to the procedure. After the patient is sedated, the physician will pass the scope through the mouth, esophagus, stomach, and into the duodenum to locate the opening where the ducts drain into the small intestine. The physician can then inject dye into these ducts and take X-rays which show a real time view, via fluoroscopy, allowing the physician to locate and relieve the blockage. This is done through multiple techniques including cutting the opening and creating a bigger hole for drainage, removing gallstones and other debris, dilating narrow parts of the ducts, or placing a stent which keeps the ducts open. The physician can also take a biopsy of the ducts to evaluate for cancer, infection, or inflammation. Side effects include bloating, nausea, or a sore throat for one to two days. Complications include pancreatitis, infection of the bile ducts or gallbladder, bleeding, reaction to the anesthesia, and perforation of any structures that the scope or its instruments pass but particularly the duodenum, bile duct, and pancreatic duct. Signs of a serious complication requiring urgent or emergent medical attention include bloody or black tarry stool, chest pain, fever, worsening abdominal pain, worsening throat pain, problems breathing, problems swallowing, vomit that is bloody or looks like coffee-grounds. Most of the time complications from this procedure require hospitalization for treatment.[18]

Disorders

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Esophagus

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Gastroesophageal reflux disease (GERD)

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See also: Gastroesophageal reflux disease
Gastroesophageal reflux

A condition that is a result of stomach contents consistently coming back up into the esophagus causing troublesome symptoms or complications.[19] Symptoms are considered troublesome based on how disruptive they are to a patient's daily life and well-being. This definition was standardized by the Montreal Consensus in 2006.[20] Symptoms include a painful feeling in the middle of the chest and feeling stomach contents coming back up into the mouth. Other symptoms include chest pain, nausea, difficulty swallowing, painful swallowing, coughing, and hoarseness.[21] Risk factors include obesity, pregnancy, smoking, hiatal hernia, certain medications, and certain foods. Diagnosis is usually based on symptoms and medical history, with further testing only after treatment has been ineffective. Further diagnosis can be achieved by measuring how much acid enters the esophagus or looking into the esophagus with a scope. Treatment and management options[19] include lifestyle modifications, medications, and surgery if there is no improvement with other interventions. Lifestyle modifications include not lying down for three hours after eating, lying down on the left side, elevating head while laying by elevating head of the bed or using extra pillows, losing weight, stopping smoking, and avoiding coffee, mint, alcohol, chocolate, fatty foods, acidic foods, and spicy foods. Medications include antacids, proton pump inhibitors, H2 receptor blockers. Surgery is usually a Nissen fundoplication and is performed by a surgeon. Complications of longstanding GERD can include inflammation of the esophagus that may cause bleeding or ulcer formation, narrowing of the esophagus leading to swallowing issues, a change in the lining of the esophagus that can increase the chances of developing cancer (Barrett's esophagus), chronic cough, asthma, inflammation of the larynx leading to hoarseness, and wearing away of tooth enamel leading to dental issues.[19][21]

Barrett's esophagus

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See also: Barrett's esophagus

A condition in which the lining of the esophagus changes to look more like the lining of the intestine and increases the risk of developing esophageal cancer.[22] There are no specific symptoms although symptoms of GERD may be present for years prior as it is associated with a 10–15% risk of Barrett's esophagus.[22] Risk factors include chronic GERD for more than 5 years, being age 50 or older, being non-Hispanic white, being male, having a family history of this disorder, belly fat, and a history of smoking.[23] Protective factors include H. pylori infection, frequent use of aspirin or other non-steroidal anti-inflammatory drugs, and diets high in fruits and vegetables.[24] Diagnosis can be made by looking into the esophagus with a scope and possibly taking a biopsy of the lining of the esophagus. Treatment includes managing GERD, destroying abnormal parts of the esophagus, removing abnormal tissue in the esophagus, and removing part of the esophagus as performed by a general surgeon.[22] Further management could include periodic surveillance with repeat scopes at certain intervals determined by the physician, likely not more frequently than every three to five years.[23] Complications from this disorder can result in a type of cancer called esophageal adenocarcinoma.[24]

Education and training

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United States

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Gastroenterology is a subspecialty of internal medicine and therefore requires three years of internal medicine residency training followed by three additional years in a dedicated gastroenterology fellowship.[1] This training is certified by the American Board of Internal Medicine (ABIM) and the American Osteopathic Board of Internal Medicine (AOBIM) and must be completed at a program accredited by the Accreditation Council for Graduate Medical Education (ACGME).[25][26][27] Other national societies that oversee training include the American College of Gastroenterology (ACG), the American Gastroenterological Association (AGA), and the American Society for Gastrointestinal Endoscopy (ASGE).[28][29][30]

Scope of practice

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Gastroenterologists see patients both in the clinic and the hospital setting. They can order diagnostic tests, prescribe medications, and perform a number of diagnostic and therapeutic procedures including colonoscopy, esophagogastroduodenoscopy (EGD), endoscopic retrograde cholangiopancreatography (ERCP), endoscopic ultrasound (EUS), and liver biopsy.[31]

Subspecialties

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Some gastroenterology trainees will complete a "fourth-year" (although this is often their seventh year of graduate medical education) in transplant hepatology, advanced interventional endoscopy, inflammatory bowel disease, motility, or other topics.

Advanced endoscopy, sometimes called interventional or surgical endoscopy, is a sub-specialty of gastroenterology that focuses on advanced endoscopic techniques for the treatment of pancreatic, hepatobiliary, and gastrointestinal disease. Interventional gastroenterologists typically undergo an additional year of rigorous training in advanced endoscopic techniques including endoscopic retrograde cholangiopancreatography, endoscopic ultrasound-guided diagnostic and interventional procedures, and advanced resection techniques including endoscopic mucosal resection and endoscopic submucosal dissection. Additionally, the performance of endoscopic bariatric procedures is also performed by some advanced endoscopists.

Hepatology, or hepatobiliary medicine, encompasses the study of the liver, pancreas, and biliary tree, and is traditionally considered a sub-specialty of gastroenterology, while proctology encompasses disorders of the anus, rectum, and colon and is considered a sub-specialty of general surgery.

Professional organizations

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  • American College of Gastroenterology (ACG)[32] - was founded in 1932 by a group of 10 gastroenterologists in New York City and now consists of over 16,000 gastroenterologists from 86 countries. The ACG sponsors conferences regionally and nationally, publishes several journals including The American Journal of Gastroenterology, Clinical and Translational Gastroenterology, and ACG Case Reports Journal, hosts continuing medical education (CME) programs, supports initiatives for fellows-in-training, develops and promotes evidence-based guidelines, supports advocacy and public policy, and provides clinical research funding consisting of $27 million in research grants and career development awards ($2.2 million in 2022).[33]
  • American Gastroenterological Association (AGA)[34] - was founded in 1897 and now includes over 16,000 members worldwide. Their mission statement reads "Empowering clinicians and researchers to improve digestive health." The AGA publishes two journals monthly titled Gastroenterology and Clinical Gastroenterology and Hepatology, sponsors an annual meeting called Digestive Disease Week (DDW), provides more than $3 million each year in research grants to over 50 investigators through the AGA Research Foundation Awards Program ($2.56 million to 61 investigators in 2022), develops and promotes evidence-based guidelines, influences public policy through AGA's Congressional Advocates Program and the AGA political action committee (PAC), and supports a variety of educational opportunities including those that qualify for continuing medical education (CME) and maintenance of certification (MOC) credits.
  • American Society for Gastrointestinal Endoscopy (ASGE)[30] - was founded in 1941 and now includes around 15,000 members worldwide. Their mission statement reads "The American Society for Gastrointestinal Endoscopy is the global leader in advancing digestive care through education, advocacy and promotion of excellence and innovation in endoscopy." The ASGE publishes a monthly journal titled Gastrointestinal Endoscopy (GIE), develops and promotes evidence-based guidelines, offers educational resources for its members, and provides advocacy resources for influencing public policy.
  • World Gastroenterology Organisation (WGO)[35] - was founded in 1958 and consists of 119 Member Societies and 4 regional affiliated associations from around the world which represents a combined 60,000 individuals. The WGO mission statement reads "To promote, to the general public and healthcare professional alike, an awareness of the worldwide prevalence and optimal care of gastrointestinal and liver disorders, and to improve care of these disorders, through the provision of high quality, accessible and independent education and training." The WGO publishes a newsletter titled the electronic World Gastroenterology News (e-WGN), develops global guidelines, engages in advocacy through World Digestive Health Day (WDHD) held yearly on 29 May, and provides educational resources including 23 training centers around the world and a Train the Trainers (TTT) program.
  • British Society of Gastroenterology
  • United European Gastroenterology

Academic journals

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References

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  1. ^ a b "What is a Gastroenterologist?". American College of Gastroenterology. Retrieved 2022-12-06.
  2. ^ "Gastrointestinal Tract MeSH Descriptor Data". meshb.nlm.nih.gov. Retrieved 2022-12-12.
  3. ^ a b "Digestive System MeSH Descriptor Data". meshb.nlm.nih.gov. Retrieved 2022-12-12.
  4. ^ "Chapter 1: All Digestive Diseases | NIDDK". National Institute of Diabetes and Digestive and Kidney Diseases. Retrieved 2022-12-08.
  5. ^ Nunn JF. Ancient Egyptian Medicine. 2002. ISBN 0-8061-3504-2.
  6. ^ van den Tweel, Jan G.; Taylor, Clive R. (April 2013). "The rise and fall of the autopsy". Virchows Archiv. 462 (4): 371–380. doi:10.1007/s00428-013-1387-3. ISSN 0945-6317.
  7. ^ Edgardo Rivera, MD James L. Abbruzzese, MD; Pancreatic, Hepatic, and Biliary Carcinomas, Medical Oncology: A Comprehensive Review [1] Archived 2007-12-12 at the Wayback Machine
  8. ^ DeStoll M: Rationis Mendendi, in Nosocomio Practico vendobonensi. Part 1 LugduniBatavarum, Haak et Socios et A et J Honkoop 1788, OCLC 23625746
  9. ^ Gilger, MA (October 2001). "Gastroenterologic endoscopy in children: past, present, and future". Current Opinion in Pediatrics. 13 (5): 429–34. doi:10.1097/00008480-200110000-00008. PMID 11801888. S2CID 39462852.
  10. ^ The Origin of Endoscopes, Olympus history
  11. ^ Anton Sebastian, A Dictionary of the History of Medicine, ISBN 1-85070-021-4
  12. ^ Prout, W. On the nature of the acid and saline matters usually existing in the stomachs of animals. – Philos. Transactions, 1824, 1, 45.
  13. ^ McClendon J. F. New hydrogen electrodes and rapid methods of determining hydrogen ion concentrations. – Amer. J. Physoil., 1915, 38, 2, 180.
  14. ^ Alvarez WC (1922). "The electrogastrogram and what it shows". JAMA: The Journal of the American Medical Association. 78 (15). JAMA: 1116. doi:10.1001/jama.1922.02640680020008. Retrieved 22 May 2020.
  15. ^ "Colonoscopy | NIDDK". National Institute of Diabetes and Digestive and Kidney Diseases. Retrieved 2022-12-08.
  16. ^ "Flexible Sigmoidoscopy | NIDDK". National Institute of Diabetes and Digestive and Kidney Diseases. Retrieved 2022-12-09.
  17. ^ "Upper GI Endoscopy | NIDDK". National Institute of Diabetes and Digestive and Kidney Diseases. Retrieved 2022-12-09.
  18. ^ "Endoscopic Retrograde Cholangiopancreatography (ERCP) | NIDDK". National Institute of Diabetes and Digestive and Kidney Diseases. Retrieved 2022-12-12.
  19. ^ a b c Kahrilas, Peter J.; Shaheen, Nicholas J.; Vaezi, Michael F. (October 2008). "American Gastroenterological Association Institute Technical Review on the Management of Gastroesophageal Reflux Disease". Gastroenterology. 135 (4): 1392–1413.e5. doi:10.1053/j.gastro.2008.08.044. ISSN 0016-5085. PMID 18801365.
  20. ^ Vakil, Nimish; van Zanten, Sander V.; Kahrilas, Peter; Dent, John; Jones, Roger; Global Consensus Group (August 2006). "The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus". The American Journal of Gastroenterology. 101 (8): 1900–1920, quiz 1943. doi:10.1111/j.1572-0241.2006.00630.x. ISSN 0002-9270. PMID 16928254. S2CID 25653840.
  21. ^ a b "Definition & Facts for GER & GERD | NIDDK". National Institute of Diabetes and Digestive and Kidney Diseases. Retrieved 2022-12-08.
  22. ^ a b c Shaheen, Nicholas J.; Falk, Gary W.; Iyer, Prasad G.; Gerson, Lauren B.; American College of Gastroenterology (January 2016). "ACG Clinical Guideline: Diagnosis and Management of Barrett's Esophagus". The American Journal of Gastroenterology. 111 (1): 30–50, quiz 51. doi:10.1038/ajg.2015.322. ISSN 1572-0241. PMC 10245082. PMID 26526079. S2CID 2274838.
  23. ^ a b Muthusamy, V. Raman; Wani, Sachin; Gyawali, C. Prakash; Komanduri, Srinadh; Bergman, Jacques; Canto, Marcia I.; Chak, Amitabh; Corley, Douglas; Falk, Gary W.; Fitzgerald, Rebecca; Haidry, Rehan; Haydek, John M.; Inadomi, John; Iyer, Prasad G.; Konda, Vani (2022-12-01). "AGA Clinical Practice Update on New Technology and Innovation for Surveillance and Screening in Barrett's Esophagus: Expert Review". Clinical Gastroenterology and Hepatology. 20 (12): 2696–2706.e1. doi:10.1016/j.cgh.2022.06.003. ISSN 1542-3565. PMC 10203866. PMID 35788412.
  24. ^ a b "Definition & Facts for Barrett's Esophagus | NIDDK". National Institute of Diabetes and Digestive and Kidney Diseases. Retrieved 2022-12-08.
  25. ^ "Mission | ABIM.org". www.abim.org. Retrieved 2022-12-08.
  26. ^ "Board Policies". American Osteopathic Board of Internal Medicine. Retrieved 2022-12-08.
  27. ^ "The ACGME for Residents and Fellows". www.acgme.org. Retrieved 2022-12-08.
  28. ^ "Program Director Resources". American College of Gastroenterology. Retrieved 2022-12-08.
  29. ^ "About Us". American Gastroenterological Association. Retrieved 2022-12-08.
  30. ^ a b "About ASGE". asge.org. Retrieved 2022-12-08.
  31. ^ "Gastroenterology". American Medical Association. Retrieved 11 July 2020.
  32. ^ "About ACG". American College of Gastroenterology. Retrieved 2022-12-16.
  33. ^ "ACG at 90 Booklet" (PDF). www.gi.org. The American College of Gastroenterology. Retrieved 16 December 2022.
  34. ^ "American Gastroenterological Association". American Gastroenterological Association. Retrieved 2022-12-16.
  35. ^ "World Gastroenterology Organisation (WGO)". World Gastroenterology Organisation (WGO). Retrieved 2022-12-16.
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