Endogenous retrovirus group V member 2, envelope

ERVV-2
Identifiers
Aliases	ERVV-2, ENVV2, HERV-V2, endogenous retrovirus group V member 2, endogenous retrovirus group V member 2, envelope
External IDs	HomoloGene: 130358; GeneCards: ERVV-2; OMA:ERVV-2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	53,051,680 bp
RNA expression pattern
	Top expressed in
	placenta; ; renal cortex; ; left lobe of thyroid gland; ; human kidney;
	n/a
	More reference expression data
	n/a
Orthologs
	100271846
	n/a
	ENSG00000268964
	n/a
	B6SEH9
	n/a
	NM_001191055
	n/a
	NP_001177984
	n/a
	Wikidata
View/Edit Human

Endogenous retrovirus group V member 2, envelope is a protein that in humans is encoded by the ERVV-2 gene. ^[3]

Function

Many human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on human chromosome 19 that has inactivating mutations in the gag and pol genes. This envelope glycoprotein gene appears to have been selectively preserved. The gene's protein product is expressed in the placenta and acts as a syncytin in Old World monkeys, but has lost the fusogenic activity in humans and other primate lineages.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000268964 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Endogenous retrovirus group V member 2, envelope". Retrieved 2017-09-13.

Function

References

Further reading