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Protein-coding gene in the species Homo sapiens
Exocyst complex component 1 is a protein that in humans is encoded by the EXOC1 gene .[ 5] [ 6] [ 7]
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane . Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000090989 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036435 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells" . Genome Res . 10 (10): 1546–60. doi :10.1101/gr.140200 . PMC 310934 PMID 11042152 . ^ Brymora A, Valova VA, Larsen MR, Roufogalis BD, Robinson PJ (Aug 2001). "The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene" . J Biol Chem . 276 (32): 29792–7. doi :10.1074/jbc.C100320200 PMID 11406615 . ^ a b "Entrez Gene: EXOC1 exocyst complex component 1" .
Hsu SC, TerBush D, Abraham M, Guo W (2004). "The exocyst complex in polarized exocytosis". Int. Rev. Cytol . International Review of Cytology. 233 : 243–65. doi :10.1016/S0074-7696(04)33006-8 . ISBN 978-0-12-364637-8 PMID 15037366 . Kee Y, Yoo JS, Hazuka CD, et al. (1998). "Subunit structure of the mammalian exocyst complex" . Proc. Natl. Acad. Sci. U.S.A . 94 (26): 14438–43. doi :10.1073/pnas.94.26.14438 PMC 25013 PMID 9405631 . Hsu SC, Hazuka CD, Roth R, et al. (1998). "Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments" . Neuron . 20 (6): 1111–22. doi :10.1016/S0896-6273(00)80493-6 PMID 9655500 . S2CID 10915358 . Matern HT, Yeaman C, Nelson WJ, Scheller RH (2001). "The Sec6/8 complex in mammalian cells: Characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells" . Proc. Natl. Acad. Sci. U.S.A . 98 (17): 9648–53. doi :10.1073/pnas.171317898 PMC 55506 PMID 11493706 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol . 21 (5): 566–9. doi :10.1038/nbt810 . PMID 12665801 . S2CID 23783563 . Inoue M, Chang L, Hwang J, et al. (2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin" (PDF) . Nature . 422 (6932): 629–33. Bibcode :2003Natur.422..629I . doi :10.1038/nature01533 . hdl :2027.42/62982 PMID 12687004 . S2CID 4395760 . Moskalenko S, Tong C, Rosse C, et al. (2004). "Ral GTPases regulate exocyst assembly through dual subunit interactions" . J. Biol. Chem . 278 (51): 51743–8. doi :10.1074/jbc.M308702200 PMID 14525976 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 .
