EPS8L3

EPS8L3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WXT
Identifiers
Aliases	EPS8L3, EPS8R3, EPS8 like 3, HYPT5
External IDs	OMIM: 614989; MGI: 2139743; HomoloGene: 15878; GeneCards: EPS8L3; OMA:EPS8L3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	109,764,027 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	107,800,216 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; rectum; ; mucosa of ileum; ; gallbladder; ; jejunal mucosa; ; duodenum; ; mucosa of sigmoid colon; ; gastric mucosa; ; pancreatic ductal cell; ; testicle;
	Top expressed in
	intestinal villus; ; ileum; ; duodenum; ; epithelium of small intestine; ; large intestine; ; colon; ; jejunum; ; left colon; ; crypt of lieberkuhn of small intestine; ; zygote;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; actin filament binding; actin binding;
Cellular component	cytoplasm; plasma membrane; ruffle membrane;
Biological process	regulation of hair cycle; Rho protein signal transduction; regulation of Rho protein signal transduction; positive regulation of ruffle assembly;
	Sources:Amigo / QuickGO
Orthologs
	79574
	99662
	ENSG00000198758
	ENSMUSG00000040600
	Q8TE67
	Q91WL0
	NM_024526; NM_133181; NM_139053; NM_001319952
	NM_133867
	NP_001306881; NP_078802; NP_573444; NP_620641
	NP_598628
	Wikidata
View/Edit Human	View/Edit Mouse

Epidermal growth factor receptor kinase substrate 8-like protein 3 is an enzyme that in humans is encoded by the EPS8L3 gene.^[5]^[6]

This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. Alternatively spliced transcript variants encoding different isoforms exist.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198758 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040600 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tocchetti A, Confalonieri S, Scita G, Di Fiore PP, Betsholtz C (Mar 2003). "In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure". Genomics. 81 (2): 234–44. doi:10.1016/S0888-7543(03)00002-8. PMID 12620401.
^ ^a ^b "Entrez Gene: EPS8L3 EPS8-like 3".

Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Offenhäuser N, Borgonovo A, Disanza A, et al. (2004). "The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway". Mol. Biol. Cell. 15 (1): 91–8. doi:10.1091/mbc.E03-06-0427. PMC 307530. PMID 14565974.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198758 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040600 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12620401-5] Tocchetti A, Confalonieri S, Scita G, Di Fiore PP, Betsholtz C (Mar 2003). "In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure". Genomics. 81 (2): 234–44. doi:10.1016/S0888-7543(03)00002-8. PMID 12620401.

[entrez-6] "Entrez Gene: EPS8L3 EPS8-like 3".

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References

Further reading