EPB41L2

EPB41L2
Identifiers
Aliases	EPB41L2, 4.1-G, 4.1G, erythrocyte membrane protein band 4.1 like 2
External IDs	OMIM: 603237; MGI: 103009; HomoloGene: 37478; GeneCards: EPB41L2; OMA:EPB41L2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q23.1-q23.2 Start 130,839,347 bp End 131,063,322 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10 A4|10 12.26 cM Start 25,359,798 bp End 25,523,519 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon epithelium of colon sural nerve tendon of biceps brachii corpus callosum dorsal motor nucleus of vagus nerve inferior olivary nucleus internal globus pallidus trigeminal ganglion right lung Top expressed in neural layer of retina tail of embryo genital tubercle lens optic nerve sciatic nerve epithelium of lens zygote retinal pigment epithelium spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity PH domain binding actin binding spectrin binding cytoskeletal protein binding structural constituent of cytoskeleton protein binding Cellular component extracellular exosome cell junction spectrin nucleus membrane focal adhesion nucleoplasm cytoplasm COP9 signalosome cytoskeleton cytosol plasma membrane cell cortex region cell cortex Biological process cortical actin cytoskeleton organization actomyosin structure organization positive regulation of protein localization to cell cortex cell cycle cell division transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2037 13822 Ensembl ENSG00000079819 ENSMUSG00000019978 UniProt O43491 O70318 RefSeq (mRNA) NM_001135554 NM_001135555 NM_001199388 NM_001199389 NM_001252660 NM_001431 NM_001350299 NM_001350301 NM_001350302 NM_001350303 NM_001350304 NM_001350305 NM_001350306 NM_001350307 NM_001350308 NM_001350309 NM_001350310 NM_001350311 NM_001350312 NM_001350313 NM_001350314 NM_001350315 NM_001350320 NM_001199265 NM_013511 NM_001358751 NM_001358753 NM_001358754 NM_001358755 RefSeq (protein) NP_001129026 NP_001129027 NP_001186317 NP_001239589 NP_001422 NP_001337228 NP_001337230 NP_001337231 NP_001337232 NP_001337233 NP_001337234 NP_001337235 NP_001337236 NP_001337237 NP_001337238 NP_001337239 NP_001337240 NP_001337241 NP_001337242 NP_001337243 NP_001337244 NP_001337249 NP_001186194 NP_038539 NP_001345680 NP_001345682 NP_001345683 NP_001345684 NP_001391726 NP_001391727 NP_001391728 NP_001391730 NP_001391731 NP_001391732 NP_001391734 NP_001391735 NP_001391736 NP_001391737 NP_001391738 NP_001391739 NP_001391740 NP_001391741 NP_001391742 NP_001391744 NP_001391745 NP_001391747 NP_001391748 NP_001391757 NP_001391758 NP_001391759 NP_001391760 NP_001391761 NP_001391762 NP_001391763 NP_001391764 NP_001391766 NP_001391767 NP_001391768 NP_001391769 NP_001391770 NP_001391771 NP_001391772 NP_001391773 NP_001391774 NP_001391775 NP_001391776 NP_001391777 NP_001391778 NP_001391779 NP_001391780 NP_001391781 NP_001391782 NP_001391783 NP_001391784 Location (UCSC) Chr 6: 130.84 – 131.06 Mb Chr 10: 25.36 – 25.52 Mb PubMed search
Wikidata
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Band 4.1-like protein 2 is a protein that in humans is encoded by the EPB41L2 gene.

Interactions

EPB41L2 has been shown to interact with FKBP2 and GRIA1.

Further reading

• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Walensky LD, Gascard P, Fields ME, Blackshaw S, Conboy JG, Mohandas N, Snyder SH (April 1998). "The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1". The Journal of Cell Biology. 141 (1): 143–53. doi:10.1083/jcb.141.1.143. PMC 2132710. PMID 9531554.
• Shen L, Liang F, Walensky LD, Huganir RL (November 2000). "Regulation of AMPA receptor GluR1 subunit surface expression by a 4. 1N-linked actin cytoskeletal association". The Journal of Neuroscience. 20 (21): 7932–40. doi:10.1523/jneurosci.20-21-07932.2000. PMC 6772741. PMID 11050113.
• Kontrogianni-Konstantopoulos A, Frye CS, Benz EJ, Huang SC (June 2001). "The prototypical 4.1R-10-kDa domain and the 4.1g-10-kDa paralog mediate fodrin-actin complex formation". The Journal of Biological Chemistry. 276 (23): 20679–87. doi:10.1074/jbc.M010581200. PMID 11274145.
• Gimm JA, An X, Nunomura W, Mohandas N (June 2002). "Functional characterization of spectrin-actin-binding domains in 4.1 family of proteins". Biochemistry. 41 (23): 7275–82. doi:10.1021/bi0256330. PMID 12044158.
• Binda AV, Kabbani N, Lin R, Levenson R (September 2002). "D2 and D3 dopamine receptor cell surface localization mediated by interaction with protein 4.1N". Molecular Pharmacology. 62 (3): 507–13. doi:10.1124/mol.62.3.507. PMID 12181426. S2CID 19901660.
• Delhommeau F, Vasseur-Godbillon C, Leclerc P, Schischmanoff PO, Croisille L, Rince P, Morinière M, Benz EJ, Tchernia G, Tamagnini G, Ribeiro L, Delaunay J, Baklouti F (October 2002). "A splicing alteration of 4.1R pre-mRNA generates 2 protein isoforms with distinct assembly to spindle poles in mitotic cells". Blood. 100 (7): 2629–36. doi:10.1182/blood.V100.7.2629. PMID 12239178.
• Lu D, Yan H, Othman T, Turner CP, Woolf T, Rivkees SA (January 2004). "Cytoskeletal protein 4.1G binds to the third intracellular loop of the A1 adenosine receptor and inhibits receptor action". The Biochemical Journal. 377 (Pt 1): 51–9. doi:10.1042/BJ20030952. PMC 1223836. PMID 12974671.
• Ralston KJ, Hird SL, Zhang X, Scott JL, Jin B, Thorne RF, Berndt MC, Boyd AW, Burns GF (August 2004). "The LFA-1-associated molecule PTA-1 (CD226) on T cells forms a dynamic molecular complex with protein 4.1G and human discs large". The Journal of Biological Chemistry. 279 (32): 33816–28. doi:10.1074/jbc.M401040200. PMID 15138281.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.