ENTPD5

ENTPD5
Identifiers
Aliases	ENTPD5, CD39L4, NTPDase-5, PCPH, ectonucleoside triphosphate diphosphohydrolase 5, ectonucleoside triphosphate diphosphohydrolase 5 (inactive)
External IDs	OMIM: 603162; MGI: 1321385; HomoloGene: 37457; GeneCards: ENTPD5; OMA:ENTPD5 - orthologs
EC number	3.6.1.42
Gene location (Human)
Chr.	Chromosome 14 (human)
End	74,019,399 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	84,455,803 bp
RNA expression pattern
	Top expressed in
	mucosa of sigmoid colon; ; rectum; ; jejunal mucosa; ; duodenum; ; liver; ; mucosa of transverse colon; ; right lobe of liver; ; human kidney; ; epithelium of colon; ; mucosa of ileum;
	Top expressed in
	proximal tubule; ; right kidney; ; human kidney; ; left lobe of liver; ; transitional epithelium of urinary bladder; ; olfactory epithelium; ; esophagus; ; right ventricle; ; jejunum; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	guanosine-diphosphatase activity; uridine-diphosphatase activity; protein binding; hydrolase activity; nucleoside-diphosphatase activity;
Cellular component	endoplasmic reticulum; extracellular region;
Biological process	'de novo' posttranslational protein folding; ATP metabolic process; protein glycosylation; protein N-linked glycosylation; cell population proliferation; positive regulation of glycolytic process; regulation of phosphatidylinositol 3-kinase signaling; nucleobase-containing small molecule catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	957
	12499
	ENSG00000187097
	ENSMUSG00000021236
	O75356
	Q9WUZ9
NM_001249; NM_001321984; NM_001321985; NM_001321986; NM_001321987;
	NM_001321988; NM_001330189; NM_001382256; NM_001382257; NM_001382258; NM_001382259; NM_001382260; NM_001382262; NM_001382263
	NM_001026214; NM_001286049; NM_001286058; NM_007647
NP_001240; NP_001308913; NP_001308914; NP_001308915; NP_001308916;
	NP_001308917; NP_001317118; NP_001369185; NP_001369186; NP_001369187; NP_001369188; NP_001369189; NP_001369191; NP_001369192
	NP_001021385; NP_001272978; NP_001272987; NP_031673
	Wikidata
View/Edit Human	View/Edit Mouse

Ectonucleoside triphosphate diphosphohydrolase 5 is an enzyme that in humans is encoded by the ENTPD5 gene.^[5]^[6]^[7]

ENTPD5 is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000187097 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021236 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chadwick BP, Frischauf AM (Oct 1997). "Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes". Mamm Genome. 8 (9): 668–72. doi:10.1007/s003359900534. PMID 9271669. S2CID 42644202.
^ Chadwick BP, Frischauf AM (Oct 1998). "The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster". Genomics. 50 (3): 357–67. doi:10.1006/geno.1998.5317. PMID 9676430.
^ ^a ^b "Entrez Gene: ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5".

Mulero JJ, Yeung G, Nelken ST, Ford JE (1999). "CD39-L4 is a secreted human apyrase, specific for the hydrolysis of nucleoside diphosphates". J. Biol. Chem. 274 (29): 20064–7. doi:10.1074/jbc.274.29.20064. PMID 10400613.
Recio JA, Zambrano N, Peña L, et al. (2000). "The human PCPH proto-oncogene: cDNA identification, primary structure, chromosomal mapping, and expression in normal and tumor cells". Mol. Carcinog. 27 (3): 229–36. doi:10.1002/(SICI)1098-2744(200003)27:3<229::AID-MC10>3.0.CO;2-Z. PMID 10708485. S2CID 21222716.
Mulero JJ, Yeung G, Nelken ST, et al. (2000). "Biochemical characterization of CD39L4". Biochemistry. 39 (42): 12924–8. doi:10.1021/bi000960y. PMID 11041857.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Blánquez MJ, Regadera J, Mariño J, et al. (2003). "Gradual deregulation and loss of PCPH expression in the progression of human laryngeal neoplasia". Mol. Carcinog. 35 (4): 186–95. doi:10.1002/mc.10091. PMID 12489110. S2CID 24074840.
Murphy-Piedmonte DM, Crawford PA, Kirley TL (2005). "Bacterial expression, folding, purification and characterization of soluble NTPDase5 (CD39L4) ecto-nucleotidase". Biochim. Biophys. Acta. 1747 (2): 251–9. doi:10.1016/j.bbapap.2004.11.017. PMID 15698960.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Regadera J, Blánquez MJ, González-Peramato P, et al. (2006). "PCPH expression is an early event in the development of testicular germ cell tumors". Int. J. Oncol. 28 (3): 595–604. doi:10.3892/ijo.28.3.595. PMID 16465363.
Villar J, Arenas MI, MacCarthy CM, et al. (2007). "PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism". Cancer Res. 67 (22): 10859–68. doi:10.1158/0008-5472.CAN-07-2041. PMID 18006831.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000187097 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021236 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9271669-5] Chadwick BP, Frischauf AM (Oct 1997). "Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes". Mamm Genome. 8 (9): 668–72. doi:10.1007/s003359900534. PMID 9271669. S2CID 42644202.

[pmid9676430-6] Chadwick BP, Frischauf AM (Oct 1998). "The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster". Genomics. 50 (3): 357–67. doi:10.1006/geno.1998.5317. PMID 9676430.

[entrez-7] "Entrez Gene: ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5".

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References

Further reading