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ELAV-like protein 3

From Wikipedia, the free encyclopedia
ELAVL3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesELAVL3, HUC, HUCL, PLE21, ELAV like neuron-specific RNA binding protein 3, ELAV like RNA binding protein 3
External IDsOMIM: 603458; MGI: 109157; HomoloGene: 31035; GeneCards: ELAVL3; OMA:ELAVL3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001420
NM_032281

NM_010487

RefSeq (protein)

NP_001411
NP_115657

NP_034617

Location (UCSC)Chr 19: 11.45 – 11.48 MbChr 9: 21.93 – 21.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ELAV-like protein 3 is a protein that in humans is encoded by the ELAVL3 gene.[5][6]

A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196361Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003410Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Van Tine BA, Knops JF, Butler A, Deloukas P, Shaw GM, King PH (Dec 1998). "Localization of HuC (ELAVL3) to chromosome 19p13.2 by fluorescence in situ hybridization utilizing a novel tyramide labeling technique". Genomics. 53 (3): 296–9. doi:10.1006/geno.1998.5468. PMID 9799595.
  6. ^ a b "Entrez Gene: ELAVL3 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)".

Further reading

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