EIF3D

EIF3D
Identifiers
Aliases	EIF3D, EIF3S7, eIF3-p66, eIF3-zeta, eukaryotic translation initiation factor 3 subunit D
External IDs	OMIM: 603915; MGI: 1933181; HomoloGene: 2782; GeneCards: EIF3D; OMA:EIF3D - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q12.3 Start 36,510,855 bp End 36,529,184 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 E1 Start 77,843,198 bp End 77,855,013 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas left ovary skin of abdomen skin of leg epithelium of nasopharynx parotid gland right uterine tube right ovary spleen body of stomach Top expressed in epiblast mandibular prominence somite abdominal wall maxillary prominence fetal liver hematopoietic progenitor cell human fetus efferent ductule endothelial cell of lymphatic vessel ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding translation initiation factor activity RNA binding mRNA cap binding Cellular component cytoplasm cytosol eukaryotic translation initiation factor 3 complex, eIF3m membrane eukaryotic translation initiation factor 3 complex eukaryotic 43S preinitiation complex eukaryotic 48S preinitiation complex Biological process formation of cytoplasmic translation initiation complex viral translational termination-reinitiation translational initiation protein biosynthesis IRES-dependent viral translational initiation cap-dependent translational initiation positive regulation of translation positive regulation of mRNA binding cytoplasmic translational initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8664 55944 Ensembl ENSG00000100353 ENSMUSG00000016554 UniProt O15371 O70194 RefSeq (mRNA) NM_003753 NM_018749 RefSeq (protein) NP_003744 NP_061219 Location (UCSC) Chr 22: 36.51 – 36.53 Mb Chr 15: 77.84 – 77.86 Mb PubMed search
Wikidata
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Eukaryotic translation initiation factor 3 subunit D (eIF3d) is a protein that in humans is encoded by the EIF3D gene.

Function

Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex.

Interactions

EIF3D has been shown to interact with PHLDA1 and EIF3A.

EIF3D has also been shown to interact with c-Jun mRNA via a non-canonical mechanism. Instead of the EIF4G protein acting as a cap-binding protein to mediate translation, EIF3D has been shown to be a cap binding protein for certain mRNAs such as c-Jun which has structures at the 5' UTR inhibiting binding of EIF4G and promoting binding of EIF3D. EIF3D as a cap binding protein has been thought of as critical to regulating gene expression under cell stress such as during glucose deprivation. For translation of c-Jun under glucose starved conditions, the cap binding activity of EIF3D increased by 10-fold.

See also

• Eukaryotic initiation factor 3 (eIF3)

Further reading

• Asano K, Kinzy TG, Merrick WC, Hershey JW (January 1997). "Conservation and diversity of eukaryotic translation initiation factor eIF3". The Journal of Biological Chemistry. 272 (2): 1101–1109. doi:10.1074/jbc.272.2.1101. PMID 8995409.
• Méthot N, Rom E, Olsen H, Sonenberg N (January 1997). "The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170". The Journal of Biological Chemistry. 272 (2): 1110–1116. doi:10.1074/jbc.272.2.1110. PMID 8995410.
• Block KL, Vornlocher HP, Hershey JW (November 1998). "Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3". The Journal of Biological Chemistry. 273 (48): 31901–31908. doi:10.1074/jbc.273.48.31901. PMID 9822659.
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, et al. (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–495. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Asano K, Shalev A, Phan L, Nielsen K, Clayton J, Valásek L, et al. (May 2001). "Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation". The EMBO Journal. 20 (9): 2326–2337. doi:10.1093/emboj/20.9.2326. PMC 125443. PMID 11331597.
• Hinz T, Flindt S, Marx A, Janssen O, Kabelitz D (May 2001). "Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product". Cellular Signalling. 13 (5): 345–352. doi:10.1016/S0898-6568(01)00141-3. PMID 11369516.
• Morris-Desbois C, Réty S, Ferro M, Garin J, Jalinot P (December 2001). "The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3". The Journal of Biological Chemistry. 276 (49): 45988–45995. doi:10.1074/jbc.M104966200. PMID 11590142.
• Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (October 2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". European Journal of Biochemistry. 270 (20): 4133–4139. doi:10.1046/j.1432-1033.2003.03807.x. PMID 14519125.
• Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, et al. (2004). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, et al. (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.