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EEF1D

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EEF1D
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEEF1D, EF-1D, EF1D, FP1047, eukaryotic translation elongation factor 1 delta
External IDsOMIM: 130592; MGI: 1913906; HomoloGene: 23404; GeneCards: EEF1D; OMA:EEF1D - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 8: 143.58 – 143.6 MbChr 15: 75.77 – 75.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Elongation factor 1-delta is a protein that in humans is encoded by the EEF1D gene.[5]

Function

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This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit functions as guanine nucleotide exchange factor. It is reported that this subunit interacts with HIV-1 Tat, and thus it represses the translation of host-cell, but not HIV-1, mRNAs. Several alternatively spliced transcript variants have been found for this gene, however, the full length nature of only two variants has been determined.[6]

Interactions

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EEF1D has been shown to interact with Glycyl-tRNA synthetase,[7] EEF1G[8][9] and KTN1,[10] and is predicted to interact with TMEM63A.[11]

References

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  1. ^ a b c ENSG00000273594 GRCh38: Ensembl release 89: ENSG00000104529, ENSG00000273594Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055762Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sanders J, Raggiaschi R, Morales J, Möller W (Jul 1993). "The human leucine zipper-containing guanine-nucleotide exchange protein elongation factor-1 delta". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1174 (1): 87–90. doi:10.1016/0167-4781(93)90097-W. PMID 8334168.
  6. ^ "Entrez Gene: EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)".
  7. ^ Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S (Feb 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochemical and Biophysical Research Communications. 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID 11829477.
  8. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  9. ^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  10. ^ Ong LL, Er CP, Ho A, Aung MT, Yu H (Aug 2003). "Kinectin anchors the translation elongation factor-1 delta to the endoplasmic reticulum". The Journal of Biological Chemistry. 278 (34): 32115–23. doi:10.1074/jbc.M210917200. PMID 12773547.
  11. ^ "String Database". Retrieved 16 May 2014.

Further reading

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