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EEF1A2

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EEF1A2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEEF1A2, EEF1AL, EF-1-alpha-2, EF1A, HS1, STN, STNL, EIEE33, MRD38, eukaryotic translation elongation factor 1 alpha 2, DEE33
External IDsOMIM: 602959; MGI: 1096317; HomoloGene: 121568; GeneCards: EEF1A2; OMA:EEF1A2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001958

NM_007906

RefSeq (protein)

NP_001949

NP_031932

Location (UCSC)Chr 20: 63.49 – 63.5 MbChr 2: 180.79 – 180.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Elongation factor 1-alpha 2 is a protein that in humans is encoded by the EEF1A2 gene.[5][6][7]

Function

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This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas.

Clinical significance

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This gene may be critical in the development of ovarian cancer.[7]

Regulation

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EEF1A2 is a direct target of miRNA-663 and miRNA-744.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101210Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000016349Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Knudsen SM, Frydenberg J, Clark BF, Leffers H (Sep 1993). "Tissue-dependent variation in the expression of elongation factor-1 alpha isoforms: isolation and characterisation of a cDNA encoding a novel variant of human elongation-factor 1 alpha". Eur J Biochem. 215 (3): 549–54. doi:10.1111/j.1432-1033.1993.tb18064.x. PMID 8354261.
  6. ^ Lund A, Knudsen SM, Vissing H, Clark B, Tommerup N (Jan 1997). "Assignment of human elongation factor 1alpha genes: EEF1A maps to chromosome 6q14 and EEF1A2 to 20q13.3". Genomics. 36 (2): 359–61. doi:10.1006/geno.1996.0475. PMID 8812466.
  7. ^ a b "Entrez Gene: EEF1A2 eukaryotic translation elongation factor 1 alpha 2".
  8. ^ Vislovukh A, Kratassiouk G, Porto E, Gralievska N, Beldiman C, Pinna G, El'skaya A, Harel-Bellan A, Negrutskii B, Groisman I (11 June 2013). "Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-744". British Journal of Cancer. 108 (11): 2304–11. doi:10.1038/bjc.2013.243. PMC 3681015. PMID 23695020.

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: Q05639 (Elongation factor 1-alpha 2) at the PDBe-KB.