EDP-305
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Formula | C36H58N2O5S |
Molar mass | 630.93 g·mol−1 |
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EDP-305 is a non-bile acid farnesoid X receptor (FXR) agonist developed by Enanta Pharmaceuticals for non-alcoholic fatty liver disease.[1][2] According to preclinical research CYP3A4 is the main enzyme used to metabolize the drug and there is a low potential for drug interactions.[3]
References
[edit]- ^ Ratziu, Vlad; Rinella, Mary E.; Neuschwander-Tetri, Brent A.; Lawitz, Eric; Denham, Douglas; Kayali, Zeid; Sheikh, Aasim; Kowdley, Kris V.; Desta, Taddese; Elkhashab, Magdy; DeGrauw, Jeffery; Goodwin, Bryan; Ahmad, Alaa; Adda, Nathalie (March 2022). "EDP-305 in patients with NASH: A phase II double-blind placebo-controlled dose-ranging study". Journal of Hepatology. 76 (3): 506–517. doi:10.1016/j.jhep.2021.10.018. PMID 34740705. S2CID 243483067.
- ^ An, Ping; Wei, Guangyan; Huang, Pinzhu; Li, Wenda; Qi, Xiaolong; Lin, Yi; Vaid, Kahini A.; Wang, Jun; Zhang, Shucha; Li, Yang; Or, Yat Sun; Jiang, Li-Juan; Popov, Yury V. (July 2020). "A novel non-bile acid FXR agonist EDP-305 potently suppresses liver injury and fibrosis without worsening of ductular reaction". Liver International. 40 (7): 1655–1669. doi:10.1111/liv.14490. PMC 7384094. PMID 32329946.
- ^ Ahmad, Alaa; Adda, Nathalie (September 2022). "Assessment of drug–drug interaction potential with EDP -305, a farnesoid X receptor agonist, in healthy subjects". Clinical and Translational Science. 15 (9): 2146–2158. doi:10.1111/cts.13348. PMC 9468552. PMID 35675500.