EDIL3

EDIL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4D90
Identifiers
Aliases	EDIL3, DEL1, EGF like repeats and discoidin domains 3
External IDs	OMIM: 606018; MGI: 1329025; HomoloGene: 21166; GeneCards: EDIL3; OMA:EDIL3 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	84,384,880 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	89,471,342 bp
RNA expression pattern
	Top expressed in
	external globus pallidus; ; inferior ganglion of vagus nerve; ; pars reticulata; ; subthalamic nucleus; ; tibia; ; pars compacta; ; superior vestibular nucleus; ; pons; ; lateral nuclear group of thalamus; ; ventral tegmental area;
	Top expressed in
	lateral geniculate nucleus; ; medial geniculate nucleus; ; medial dorsal nucleus; ; anterior horn of spinal cord; ; globus pallidus; ; calvaria; ; deep cerebellar nuclei; ; ventral tegmental area; ; lateral hypothalamus; ; suprachiasmatic nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; integrin binding; metal ion binding; extracellular matrix structural constituent;
Cellular component	extracellular vesicle; extracellular region; extracellular exosome; extracellular matrix; collagen-containing extracellular matrix;
Biological process	multicellular organism development; cell adhesion; positive regulation of cell-substrate adhesion;
	Sources:Amigo / QuickGO
Orthologs
	10085
	13612
	ENSG00000164176
	ENSMUSG00000034488
	O43854
	O35474
	NM_001278642; NM_005711
	NM_001037987; NM_010103
	NP_001265571; NP_005702
	NP_001033076; NP_034233
	Wikidata
View/Edit Human	View/Edit Mouse

EGF like repeats and discoidin domains 3 is a protein that in humans is encoded by the EDIL3 gene. ^[5]

Function

The protein encoded by this gene is an integrin ligand. It plays an important role in mediating angiogenesis and may be important in vessel wall remodeling and development. It also influences endothelial cell behavior.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164176 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034488 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: EGF like repeats and discoidin domains 3". Retrieved 2017-07-24.

Rezaee M, Penta K, Quertermous T (2002). "Del1 mediates VSMC adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3)". Am. J. Physiol. Heart Circ. Physiol. 282 (5): H1924–32. doi:10.1152/ajpheart.00921.2001. PMID 11959660.
Aoka Y, Johnson FL, Penta K, Hirata Ki K, Hidai C, Schatzman R, Varner JA, Quertermous T (2002). "The embryonic angiogenic factor Del1 accelerates tumor growth by enhancing vascular formation". Microvascular Research. 64 (1): 148–61. doi:10.1006/mvre.2002.2414. PMID 12074641.
Niu JX, Zhang WJ, Ye LY, Wu LQ, Zhu GJ, Yang ZH, Grau GE, Lou JN (2007). "The role of adhesion molecules, alpha v beta 3, alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion". Eur. J. Cancer Prev. 16 (6): 517–27. doi:10.1097/CEJ.0b013e3280145c00. PMID 18090124. S2CID 1825380.
Zou X, Qiao H, Jiang X, Dong X, Jiang H, Sun X (2009). "Downregulation of developmentally regulated endothelial cell locus-1 inhibits the growth of colon cancer". J. Biomed. Sci. 16 (1): 33. doi:10.1186/1423-0127-16-33. PMC 2666667. PMID 19292890.
Johnson MP, Roten LT, Dyer TD, East CE, Forsmo S, Blangero J, Brennecke SP, Austgulen R, Moses EK (2009). "The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations". Hum. Genet. 126 (5): 655–66. doi:10.1007/s00439-009-0714-x. PMC 2783187. PMID 19578876.
Bozaoglu K, Curran JE, Stocker CJ, Zaibi MS, Segal D, Konstantopoulos N, Morrison S, Carless M, Dyer TD, Cole SA, Goring HH, Moses EK, Walder K, Cawthorne MA, Blangero J, Jowett JB (2010). "Chemerin, a novel adipokine in the regulation of angiogenesis". J. Clin. Endocrinol. Metab. 95 (5): 2476–85. doi:10.1210/jc.2010-0042. PMC 2869547. PMID 20237162.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Sun JC, Liang XT, Pan K, Wang H, Zhao JJ, Li JJ, Ma HQ, Chen YB, Xia JC (2010). "High expression level of EDIL3 in HCC predicts poor prognosis of HCC patients". World J. Gastroenterol. 16 (36): 4611–5. doi:10.3748/wjg.v16.i36.4611. PMC 2945496. PMID 20857535.
Glessner JT, Bradfield JP, Wang K, Takahashi N, Zhang H, Sleiman PM, Mentch FD, Kim CE, Hou C, Thomas KA, Garris ML, Deliard S, Frackelton EC, Otieno FG, Zhao J, Chiavacci RM, Li M, Buxbaum JD, Berkowitz RI, Hakonarson H, Grant SF (2010). "A genome-wide study reveals copy number variants exclusive to childhood obesity cases". Am. J. Hum. Genet. 87 (5): 661–6. doi:10.1016/j.ajhg.2010.09.014. PMC 2978976. PMID 20950786.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164176 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034488 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: EGF like repeats and discoidin domains 3". Retrieved 2017-07-24.

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Function

References

Further reading