Draft:Nanonephrology
| Submission declined on 13 September 2024 by Robert McClenon (talk). The proposed article does not have sufficient content to require an article of its own, but it could be merged into the existing article at Nanomedicine. Since anyone can edit Wikipedia, you are welcome to add that information yourself. Thank you.
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Comment: This draft is a draft on a subtopic of an existing article, Nanomedicine. Discussion as to whether a separate article for the subtopic is warranted should be on the talk page of the parent article, Talk:Nanomedicine.Please discuss the suitability of creating a separate subtopic article on the talk page of the parent article. Please resubmit this draft if there is rough consensus at the parent talk page to create the child article, or with an explanation that the child draft satisfies either general notability on its own or a special notability guide.A few months ago, I said that there should be discussion at Talk:Nanomedicine as to whether a separate article was needed. There has not been discussion. If there is a case for a separate article, please resume discussion at Talk:Nanomedicine. Robert McClenon (talk) 04:35, 13 September 2024 (UTC)
- Comment: Note to AFC Reviewers: This draft is for a title that was previously an article, but was then cut down to a redirect. If this draft is accepted, the history should be preserved. Do not tag the redirect for G6. If you find that this draft should be accepted, and do not have the Page Mover privilege, please request assistance in moving the redirect to preserve the history. Reviewers should check the history and verify whether there was a consensus to cut the article down to a redirect, or whether the action was taken boldly without discussion. If there was a consensus for the cutdown, do not accept this draft without verifying that the draft improves the article or that consensus has changed. If in doubt, please discuss.
- Comment: Notable and well sourced, thank you Ozzie10aaaa (talk) 14:39, 9 July 2024 (UTC)
- Comment: The previous article on nanonephrology was cut down to a redirect unilaterally. Acceptance of this draft should reflect consensus at Talk:Nanomedicine. Robert McClenon (talk) 19:26, 9 June 2024 (UTC)
Nanonephrology is an emerging field that combines nanotechnology with nephrology to develop new diagnostic, therapeutic, and monitoring techniques for kidney diseases; it is thus a sub-discipline of nanomedicine. The application of nanonephrology aims to improve the understanding of renal physiology and pathology at the molecular level, enhance drug delivery systems, and create innovative medical devices for better disease management.[1]
Background
[edit]Nanotechnology involves the manipulation of materials at the nanometer scale (one billionth of a meter), enabling the creation of structures, devices, and systems with novel properties and functions.[2] In nephrology, nanotechnology offers significant potential to revolutionize the diagnosis and treatment of kidney diseases, which affect millions of people worldwide. This interdisciplinary field, termed nano-nephrology, focuses on leveraging nanomaterials and nanodevices to address various challenges in kidney health.[citation needed]
Diagnostic applications
[edit]- Early Detection of Kidney Diseases: Traditional diagnostic methods for kidney diseases often detect the condition at a later stage when significant damage has already occurred. Nanotechnology enables the development of sensitive diagnostic tools that can detect biomarkers at very low concentrations, allowing for earlier diagnosis and intervention.[3]
- Imaging: Nanoparticles can be designed to improve imaging techniques such as MRI, CT scans, and ultrasounds. For example, superparamagnetic iron oxide nanoparticles (SPIONs) enhance the contrast in MRI, providing clearer images of kidney structures and pathology.[citation needed]
Therapeutic applications
[edit]- Targeted Drug Delivery: Nanocarriers, such as liposomes, dendrimers, and polymeric nanoparticles, can be engineered to deliver drugs specifically to the kidneys, minimizing systemic side effects and improving therapeutic efficacy. This is particularly beneficial in treating chronic kidney disease (CKD) and renal cancers.[4]
- Regenerative Medicine: Nanotechnology plays a crucial role in tissue engineering and regenerative medicine. Nanomaterials can be used to create scaffolds that support the growth of new kidney tissues, offering potential treatments for end-stage renal disease (ESRD).[citation needed]
Monitoring and management
[edit]- Smart Drug Delivery Systems: Nanotechnology enables the development of smart drug delivery systems that can release medication in response to specific physiological triggers, ensuring optimal drug levels and reducing the need for frequent dosing.[5]
- Biosensors: Nanosensors can monitor various physiological parameters, such as glomerular filtration rate (GFR) and electrolyte levels, in real-time. These sensors can be integrated into wearable devices, providing continuous monitoring and early warning of potential issues.[6]
Challenges and future directions
[edit]Despite the promising advancements, nano-nephrology faces several challenges, including the biocompatibility and toxicity of nanomaterials, scalability of nanotechnology-based solutions, and regulatory hurdles. Ongoing research is focused on addressing these issues to ensure the safe and effective integration of nanotechnology into nephrology.[citation needed]
Future directions in nano-nephrology include the development of personalized nanomedicine approaches tailored to individual patients' genetic and molecular profiles, advancing the precision and effectiveness of treatments. Furthermore, interdisciplinary collaboration among nephrologists, materials scientists, and bioengineers will be crucial for the continued progress of this field.[citation needed]
References
[edit]- ^ Makar, A. B.; McMartin, K. E.; Palese, M.; Tephly, T. R. (June 1975). "Formate assay in body fluids: application in methanol poisoning". Biochemical Medicine. 13 (2): 117–126. doi:10.1016/0006-2944(75)90147-7. ISSN 0006-2944. PMID 1.
- ^ Davenport, Andrew (2009), "Treatment of Combined Acute Renal Failure and Cerebral Edema", Critical Care Nephrology, Elsevier, pp. 1069–1073, doi:10.1016/b978-1-4160-4252-5.50206-9, ISBN 978-1-4160-4252-5, retrieved 2024-06-06
- ^ Kim, Chan Ho; Moon, Sung Jin (2021-12-31). "The role of the gut microbiota in acute kidney injury: a new therapeutic candidate?". Kidney Research and Clinical Practice. 40 (4): 505–507. doi:10.23876/j.krcp.21.241. ISSN 2211-9140. PMC 8685367. PMID 34922426.
- ^ Murugan, Baranya (2021), "Skin Cancer Treatment with Emphasis on Nanotechnology", Skin Cancer: Pathogenesis and Diagnosis, Singapore: Springer Singapore, pp. 193–209, doi:10.1007/978-981-16-0364-8_11, ISBN 978-981-16-0363-1, retrieved 2024-06-06
- ^ "Nanomaterial-Based Electrochemical DNA Detection", Electrochemical DNA Biosensors, Jenny Stanford Publishing, pp. 445–498, 2012-04-23, doi:10.1201/b11988-16, ISBN 978-0-429-06641-2, retrieved 2024-06-06
- ^ Zhao, Lingfei; Hu, Chenxia; Zhang, Ping; Jiang, Hua; Chen, Jianghua (2019-04-17). "Genetic communication by extracellular vesicles is an important mechanism underlying stem cell-based therapy-mediated protection against acute kidney injury". Stem Cell Research & Therapy. 10 (1): 119. doi:10.1186/s13287-019-1227-8. ISSN 1757-6512. PMC 6471862. PMID 30995947.