Draft:NNC2215

Submission declined on 17 December 2024 by KylieTastic (talk).

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Declined by KylieTastic 2 seconds ago. Last edited by KylieTastic 2 seconds ago. Reviewer: Inform author.

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NNC2215 is a bioengineered glucose sensitive insulin.^[1]

The study was published on Nature on October 16, 2024.

Function

NNC2215 can sense the glucose concentration. The protein's sensitivity is reduced when low concentration of glucose, thus reducing the risk of hypoglycemia.

References

^ Hoeg-Jensen, Thomas; Kruse, Thomas; Brand, Christian L.; Sturis, Jeppe; Fledelius, Christian; Nielsen, Peter K.; Nishimura, Erica; Madsen, Alice R.; Lykke, Lennart; Halskov, Kim S.; Koščová, Simona; Kotek, Vladislav; Davis, Anthony P.; Tromans, Robert A.; Tomsett, Michael (16 October 2024). "Glucose-sensitive insulin with attenuation of hypoglycaemia". Nature. 634 (8035): 944–951. doi:10.1038/s41586-024-08042-3. ISSN 1476-4687.

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[1] Hoeg-Jensen, Thomas; Kruse, Thomas; Brand, Christian L.; Sturis, Jeppe; Fledelius, Christian; Nielsen, Peter K.; Nishimura, Erica; Madsen, Alice R.; Lykke, Lennart; Halskov, Kim S.; Koščová, Simona; Kotek, Vladislav; Davis, Anthony P.; Tromans, Robert A.; Tomsett, Michael (16 October 2024). "Glucose-sensitive insulin with attenuation of hypoglycaemia". Nature. 634 (8035): 944–951. doi:10.1038/s41586-024-08042-3. ISSN 1476-4687.

[1]

Function

See also

References