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Draft:Louise Rollins-Smith

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Louise Rollins-Smith
NationalityAmerican
Alma materHamline University, University of Minnesota
Scientific career
FieldsImmunology, Amphibians, Antimicrobial peptides
InstitutionsVanderbilt University
Thesis (1977)
Doctoral advisorRobert G. McKinnell

Louise Rollins-Smith is an American amphibian disease researcher. She is a Professor of Biological Sciences, Professor of Paediatrics, and a Professor of Pathology, Microbiology and Immunology at Vanderbilt University[1].

Career and research

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Rollins-Smith received her Bachelor's degree in Biology at Hamline University, Saint Paul, Minnesota, before completing a Masters and a PhD in Zoology at the University of Minnesota in 1977[2]. Rollins-Smith was a postdoctoral researcher at the University of Rochester before joining Vanderbilt University in 1984[3].

Rollins-Smith has studied disease and immunity in amphibians for more than 40 years and has published over 150 peer-reviewed journal articles[4][5]. Her early research was focused upon Lucké renal adenocarcinoma of leopard frogs[6][7], the development of immunological tolerance and immune changes at metamorphosis in frogs[8]. Rollins-Smith has also studied the effects of immunotoxic and agricultural chemicals on amphibian immunity[9][10].

Since the link between widespread amphibian declines and the amphibian chytrid fungi, Bactrochochytrium dendrobatidis (Bd) and Batrachochytrium salamandrivorans (Bsal), Rollins-Smith's research has became more focused on these pathogens in relation to amphibian immunity. Her research has shown mechanisms of immune evasion by Bd and Bsal, including that both pathogens release factors which inhibit lymphocyte responses[11][12][13][14]. Rollins-Smith has also become well-known for her work on amphibian skin antimicrobial peptides (AMPs). Alongside her colleagues, she has provided evidence that the effectiveness of AMPs is a valuable predictor of amphibian species susceptibility to the Bd[15][16][17], and that AMPs are potent inhibitors of viral infection, including HIV infection of human T lymphocytes[18].

References

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  1. ^ "Louise A. Rollins-Smith, Ph.D. | Vanderbilt Institute for Infection, Immunology and Inflammation". www.vumc.org. Retrieved 2023-12-12.
  2. ^ "Vanderbilt University School of Medicine". wag.app.vanderbilt.edu. Retrieved 2023-12-12.
  3. ^ "Rollins-Smith Lab Members | The Rollins-Smith Lab". www.vumc.org. Retrieved 2023-12-12.
  4. ^ "Louise Rollins-Smith". scholar.google.com. Retrieved 2023-12-12.
  5. ^ "LinkedIn Profile - Louise Rollins-Smith".
  6. ^ "Effect of Thyroxine on Induction of Lucké Renal Adenocarcinomas in Lucké Tumor Herpesvirus-Infected Leopard Frog Tadpoles2". JNCI: Journal of the National Cancer Institute. September 1984. doi:10.1093/jnci/73.3.717. ISSN 1460-2105.
  7. ^ "Effect of Thymectomy on Development of Lucké Renal Adenocarcinomas in Virus-Infected Leopard Frog Tadpoles23". JNCI: Journal of the National Cancer Institute. January 1982. doi:10.1093/jnci/68.1.133. ISSN 1460-2105.
  8. ^ Rollins-Smith, Louise A.; Blair, Patrick J.; Davis, A. Tray (1992). "Thymus Ontogeny in Frogs: T-Cell Renewal at Metamorphosis". Journal of Immunology Research. 2 (3): 207–213. doi:10.1155/1992/26251. ISSN 2314-8861. PMC 2275863. PMID 1320967.
  9. ^ Rollins-Smith, Louise A.; Hopkins, B. Diane (1997-03-01). "F2 2:00 Immunotoxic effects of diazinon and lead on the developing hematopoietic system of Xenopus laevis". Developmental & Comparative Immunology. The 7th Congress of The International Society of Developmental and Comparative Immunology. 21 (2): 121. doi:10.1016/S0145-305X(97)88572-2. ISSN 0145-305X.
  10. ^ Christin, M. S.; Ménard, L.; Gendron, A. D.; Ruby, S.; Cyr, D.; Marcogliese, D. J.; Rollins-Smith, L.; Fournier, M. (2004-03-30). "Effects of agricultural pesticides on the immune system of Xenopus laevis and Rana pipiens". Aquatic Toxicology. 67 (1): 33–43. doi:10.1016/j.aquatox.2003.11.007. ISSN 0166-445X. PMID 15019249.
  11. ^ Fites, J. Scott; Ramsey, Jeremy P.; Holden, Whitney M.; Collier, Sarah P.; Sutherland, Danica M.; Reinert, Laura K.; Gayek, A. Sophia; Dermody, Terence S.; Aune, Thomas M.; Oswald-Richter, Kyra; Rollins-Smith, Louise A. (2013-10-18). "The Invasive Chytrid Fungus of Amphibians Paralyzes Lymphocyte Responses". Science. 342 (6156): 366–369. Bibcode:2013Sci...342..366F. doi:10.1126/science.1243316. ISSN 0036-8075. PMC 3956111. PMID 24136969.
  12. ^ Rollins-Smith, Louise A.; Fites, J. Scott; Reinert, Laura K.; Shiakolas, Andrea R.; Umile, Thomas P.; Minbiole, Kevin P. C. (December 2015). Deepe, G. S. (ed.). "Immunomodulatory Metabolites Released by the Frog-Killing Fungus Batrachochytrium dendrobatidis". Infection and Immunity. 83 (12): 4565–4570. doi:10.1128/IAI.00877-15. ISSN 0019-9567. PMC 4645405. PMID 26371122.
  13. ^ Fites, J. Scott; Reinert, Laura K.; Chappell, Timothy M.; Rollins-Smith, Louise A. (November 2014). Deepe, G. S. (ed.). "Inhibition of Local Immune Responses by the Frog-Killing Fungus Batrachochytrium dendrobatidis". Infection and Immunity. 82 (11): 4698–4706. doi:10.1128/IAI.02231-14. ISSN 0019-9567. PMC 4249309. PMID 25156734.
  14. ^ Rollins-Smith, Louise A.; Reinert, Laura K.; Le Sage, Mitchell; Linney, Kaitlyn N.; Gillard, Bria M.; Umile, Thomas P.; Minbiole, Kevin P. C. (2022-03-17). Noverr, Mairi C. (ed.). "Lymphocyte Inhibition by the Salamander-Killing Chytrid Fungus, Batrachochytrium salamandrivorans". Infection and Immunity. 90 (3): e0002022. doi:10.1128/iai.00020-22. ISSN 0019-9567. PMC 8929357. PMID 35130454.
  15. ^ Rollins-Smith, Louise A. (2009-08-01). "The role of amphibian antimicrobial peptides in protection of amphibians from pathogens linked to global amphibian declines". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1788 (8): 1593–1599. doi:10.1016/j.bbamem.2009.03.008. ISSN 0005-2736. PMID 19327341.
  16. ^ Rollins-Smith, Louise A.; Doersam, Jennifer K.; Longcore, Joyce E.; Taylor, Sharon K.; Shamblin, Jessica C.; Carey, Cynthia; Zasloff, Michael A. (2002-01-01). "Antimicrobial peptide defenses against pathogens associated with global amphibian declines". Developmental & Comparative Immunology. 26 (1): 63–72. doi:10.1016/S0145-305X(01)00041-6. ISSN 0145-305X. PMID 11687264.
  17. ^ Woodhams, D. C.; Ardipradja, K.; Alford, R. A.; Marantelli, G.; Reinert, L. K.; Rollins‐Smith, L. A. (2007). "Resistance to chytridiomycosis varies among amphibian species and is correlated with skin peptide defenses". Animal Conservation. 10 (4): 409–417. Bibcode:2007AnCon..10..409W. doi:10.1111/j.1469-1795.2007.00130.x. ISSN 1367-9430.
  18. ^ VanCompernolle, Scott E.; Taylor, R. Jeffery; Oswald-Richter, Kyra; Jiang, Jiyang; Youree, Bryan E.; Bowie, John H.; Tyler, Michael J.; Conlon, J. Michael; Wade, David; Aiken, Christopher; Dermody, Terence S.; KewalRamani, Vineet N.; Rollins-Smith, Louise A.; Unutmaz, Derya (2005-09-15). "Antimicrobial Peptides from Amphibian Skin Potently Inhibit Human Immunodeficiency Virus Infection and Transfer of Virus from Dendritic Cells to T Cells". Journal of Virology. 79 (18): 11598–11606. doi:10.1128/JVI.79.18.11598-11606.2005. ISSN 0022-538X. PMC 1212620. PMID 16140737.
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Category:Women scientists Category:Immunologists Category:Amphibian diseases Category:American scientists

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