Draft:Amelogen

Submission declined on 19 July 2024 by Cambalachero (talk).

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Declined by Cambalachero 3 months ago. Last edited by Cambalachero 3 months ago. Reviewer: Inform author.

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Submission declined on 16 May 2024 by Cambalachero (talk).

This submission provides insufficient context for those unfamiliar with the subject matter. Please see the guide to writing better articles for information on how to better format your submission.

Declined by Cambalachero 5 months ago.

Comment: No changes since last decline Cambalachero (talk) 01:24, 19 July 2024 (UTC)

ACP4(Acid Phosphatase 4) is a protein that in humans is encoded by ACP4 gene.^[1]

[Function]

ACP4 is involved in biomineralization during tooth enamel development.^[2]

[Clinical Significance]

Mutations in ACP4 result in amelogenesis imperfecta. It has been shown that mice with a knocked-out ACP4 gene will present disorganized and hypoplastic enamel.^[3]

References

^ "GeneCards".
^ Liang, Tian; Wang, Shih-Kai; Smith, Charles; Zhang, Hong; Hu, Yuanyuan; Seymen, Figen; Koruyucu, Mine; Kasimoglu, Yelda; Kim, Jung-Wook; Zhang, Chuhua; Saunders, Thomas L.; Simmer, James P.; Hu, Jan C.-C. (2022-10-01). "Enamel defects in Acp4R110C/R110C mice and human ACP4 mutations". Scientific Reports. 12 (1): 16477. doi:10.1038/s41598-022-20684-9. ISSN 2045-2322. PMC 9526733. PMID 36183038.
^ Kim, Y. J.; Lee, Y.; Kasimoglu, Y.; Seymen, F.; Simmer, J. P.; Hu, J. C.-C.; Cho, E.-S.; Kim, J.-W. (January 2022). "Recessive Mutations in ACP4 Cause Amelogenesis Imperfecta". Journal of Dental Research. 101 (1): 37–45. doi:10.1177/00220345211015119. ISSN 1544-0591. PMC 8721729. PMID 34036831.

[1] "GeneCards".

[2] Liang, Tian; Wang, Shih-Kai; Smith, Charles; Zhang, Hong; Hu, Yuanyuan; Seymen, Figen; Koruyucu, Mine; Kasimoglu, Yelda; Kim, Jung-Wook; Zhang, Chuhua; Saunders, Thomas L.; Simmer, James P.; Hu, Jan C.-C. (2022-10-01). "Enamel defects in Acp4R110C/R110C mice and human ACP4 mutations". Scientific Reports. 12 (1): 16477. doi:10.1038/s41598-022-20684-9. ISSN 2045-2322. PMC 9526733. PMID 36183038.

[3] Kim, Y. J.; Lee, Y.; Kasimoglu, Y.; Seymen, F.; Simmer, J. P.; Hu, J. C.-C.; Cho, E.-S.; Kim, J.-W. (January 2022). "Recessive Mutations in ACP4 Cause Amelogenesis Imperfecta". Journal of Dental Research. 101 (1): 37–45. doi:10.1177/00220345211015119. ISSN 1544-0591. PMC 8721729. PMID 34036831.

[1]

[2]

[3]