Dotinurad

Dotinurad
Clinical data
Trade names	Urece
Other names	FYU-981
Legal status
Legal status	Rx-only (Japan);
Identifiers
	IUPAC name (3,5-dichloro-4-hydroxyphenyl)-(1,1-dioxo-2H-1,3-benzothiazol-3-yl)methanone;
CAS Number	1285572-51-1;
PubChem CID	51349053;
DrugBank	DB16145;
ChemSpider	59718651;
UNII	305EB53128;
KEGG	D11071;
ChEMBL	ChEMBL4594446;
Chemical and physical data
Formula	C14H9Cl2NO4S
Molar mass	358.19 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1N(C2=CC=CC=C2S1(=O)=O)C(=O)C3=CC(=C(C(=C3)Cl)O)Cl;
	InChI InChI=1S/C14H9Cl2NO4S/c15-9-5-8(6-10(16)13(9)18)14(19)17-7-22(20,21)12-4-2-1-3-11(12)17/h1-6,18H,7H2; Key:VOFLAIHEELWYGO-UHFFFAOYSA-N;

Dotinurad (Urece) is a drug for the treatment of gout and hyperuricemia.^[1]^[2] It was developed by Fuji Yakuhin and approved for use in Japan in 2020.^[2]^[3] The drug is continuing clinical trials by Fortress Biotech and regulatory evaluation for approval in North America and Europe.^[3]^[4]

Dotinurad acts as a selective urate reabsorption inhibitor that has uric acid lowering activity by inhibiting URAT1/SLC22A12 receptor. It is a structural analog of Benzbromarone. ^[5]^[6]

References

^ Kuriyama S (March 2020). "Dotinurad: a novel selective urate reabsorption inhibitor as a future therapeutic option for hyperuricemia". Clinical and Experimental Nephrology. 24 (Suppl 1): 1–5. doi:10.1007/s10157-019-01811-9. PMC 7066308. PMID 31754883.
^ ^a ^b "List of Approved Products" (PDF). Pharmaceuticals and Medical Devices Agency.
^ ^a ^b "Fortress takes on dotinurad in USA and Europe". November 5, 2020. Retrieved June 23, 2021.
^ "Fortress Biotech Announces Exclusive License Agreement With Fuji Yakuhin to Develop Dotinurad in North America and Europe". May 10, 2021. Retrieved June 23, 2021.
^ Taniguchi T, Ashizawa N, Matsumoto K, Saito R, Motoki K, Sakai M, et al. (October 2019). "Pharmacological Evaluation of Dotinurad, a Selective Urate Reabsorption Inhibitor". The Journal of Pharmacology and Experimental Therapeutics. 371 (1): 162–170. doi:10.1124/jpet.119.259341. PMID 31371478. S2CID 199382932.
^ Uda J, Kobashi S, Miyata S, Ashizawa N, Matsumoto K, Iwanaga T (October 2020). "Discovery of Dotinurad (FYU-981), a New Phenol Derivative with Highly Potent Uric Acid Lowering Activity". ACS Medicinal Chemistry Letters. 11 (10): 2017–2023. doi:10.1021/acsmedchemlett.0c00176. PMC 7549256. PMID 33062187.

[1] Kuriyama S (March 2020). "Dotinurad: a novel selective urate reabsorption inhibitor as a future therapeutic option for hyperuricemia". Clinical and Experimental Nephrology. 24 (Suppl 1): 1–5. doi:10.1007/s10157-019-01811-9. PMC 7066308. PMID 31754883.

[pmda-2] "List of Approved Products" (PDF). Pharmaceuticals and Medical Devices Agency.

[thepharmaletter-3] "Fortress takes on dotinurad in USA and Europe". November 5, 2020. Retrieved June 23, 2021.

[4] "Fortress Biotech Announces Exclusive License Agreement With Fuji Yakuhin to Develop Dotinurad in North America and Europe". May 10, 2021. Retrieved June 23, 2021.

[5] Taniguchi T, Ashizawa N, Matsumoto K, Saito R, Motoki K, Sakai M, et al. (October 2019). "Pharmacological Evaluation of Dotinurad, a Selective Urate Reabsorption Inhibitor". The Journal of Pharmacology and Experimental Therapeutics. 371 (1): 162–170. doi:10.1124/jpet.119.259341. PMID 31371478. S2CID 199382932.

[6] Uda J, Kobashi S, Miyata S, Ashizawa N, Matsumoto K, Iwanaga T (October 2020). "Discovery of Dotinurad (FYU-981), a New Phenol Derivative with Highly Potent Uric Acid Lowering Activity". ACS Medicinal Chemistry Letters. 11 (10): 2017–2023. doi:10.1021/acsmedchemlett.0c00176. PMC 7549256. PMID 33062187.

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