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Donna R. Maglott

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Donna R. Maglott
Alma materUniversity of Michigan
Scientific career
InstitutionsNational Center for Biotechnology Information
ThesisThe structure and function of the 50S ribosome of Escherichia coli (1970)

Donna R. Maglott is a staff scientist at the National Center for Biotechnology Information known for her research on large-scale genomics projects, including the mouse genome and development of databases required for genomics research.

Education and career

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Maglott earned her Ph.D. in 1970 from the University of Michigan where she worked on the 50S ribosome in the bacterium Escherichia coli.[1] She held an academic position at Howard University;[when?] and then moved to the American Type Culture Center in 1986 where she began establishing databases needed for genomic research.[2][3] She started at the National Center for Biotechnology Information (NCBI) in 1998.[4]

Research

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While at Howard University, Maglott worked on protein synthesis during early development of sea urchins.[5][6] At ATCC, she worked on repositories holding clone and genomic information[7][8] and began research using genomic tools to investigate information on human chromosomes.[9][10] In 2000, Maglott worked with Kim D. Pruitt to introduce RefSeq, a web-based resource for gene-based information that is hosted by NCBI[11][12] and has been updated over the years.[13][14] She has also been involved in the development of other databases at NCBI including Entrez Gene,[15][16] ClinVar,[17][18] STS markers, Conserved CoDing Sequences (CCDS), Map Viewer, RefSeqGene, the NIH Genetic Testing Registry (GTR), MedGen, and ClinVar.[4] Large-scale genomics projects that Margott has worked on include the rat genome database,[19] and the mouse genome[20][21] and transcriptome.[22] In 2006, Maglott was a part of the team analyzing the genome of the sea urchin, Strongylocentrotus purpuratus, which was the first genome obtained for a motile marine invertebrate.[23][24]

Selected publications

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  • Mouse Genome Sequencing Consortium (2002). "Initial sequencing and comparative analysis of the mouse genome". Nature. 420 (6915): 520–562. Bibcode:2002Natur.420..520W. doi:10.1038/nature01262. ISSN 0028-0836. PMID 12466850.
  • Maglott, D. (2004-12-17). "Entrez Gene: gene-centered information at NCBI". Nucleic Acids Research. 33 (Database issue): D54–D58. doi:10.1093/nar/gki031. ISSN 1362-4962. PMC 539985. PMID 15608257.
  • Pruitt, Kim D.; Tatusova, Tatiana; Maglott, Donna R. (2007-01-01). "NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins". Nucleic Acids Research. 35 (Database issue): D61–65. doi:10.1093/nar/gkl842. ISSN 1362-4962. PMC 1716718. PMID 17130148.
  • The International Aphid Genomics Consortium (2010-02-23). Eisen, Jonathan A. (ed.). "Genome Sequence of the Pea Aphid Acyrthosiphon pisum". PLOS Biology. 8 (2): e1000313. doi:10.1371/journal.pbio.1000313. ISSN 1545-7885. PMC 2826372. PMID 20186266.
  • Landrum, Melissa J.; Lee, Jennifer M.; Riley, George R.; Jang, Wonhee; Rubinstein, Wendy S.; Church, Deanna M.; Maglott, Donna R. (2014). "ClinVar: public archive of relationships among sequence variation and human phenotype". Nucleic Acids Research. 42 (D1): D980–D985. doi:10.1093/nar/gkt1113. ISSN 0305-1048. PMC 3965032. PMID 24234437.

References

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  1. ^ Maglott, Donna Rae Schneider (1970). The structure and function of the 50S ribosome of Escherichia coli (Thesis). Ann Arbor - Mich. OCLC 633231185.
  2. ^ "Center for Bioinformatics and Computational Biology". www.cbcb.umd.edu. 2006. Archived from the original on 2007-08-17. Retrieved 2021-10-02.
  3. ^ "Donna Maglott, PhD - ClinGen | Clinical Genome Resource". 2017-07-10. Archived from the original on 2017-07-10. Retrieved 2021-10-02.
  4. ^ a b "Human Variome Project". www.humanvariomeproject.org. Retrieved 2016-12-18.
  5. ^ Maglott, D.R. (1985). "Dissociation of cells from sea urchin embryos alters the synthesis of actins and other proteins". Cell Differentiation. 17 (1): 29–43. doi:10.1016/0045-6039(85)90535-4. PMID 3875415.
  6. ^ Maglott, D.R. (1985). "Two-dimensional electrophoretic analysis of major phosphoproteins of the sea urchin, Arbacia punctulata". Comparative Biochemistry and Physiology Part B: Comparative Biochemistry. 80 (3): 513–516. doi:10.1016/0305-0491(85)90282-2. PMID 4006443.
  7. ^ Maglott, Donna R.; Nierman, William C. (1990-11-01). "Clone and genomic repositories at the American Type Culture Collection". Genomics. 8 (3): 601–605. doi:10.1016/0888-7543(90)90054-X. ISSN 0888-7543. PMID 1981058.
  8. ^ Maglott, Donna R.; Nierman, William C. (1991). "Mammalian probes and libraries at the ATCC". Mammalian Genome. 1 (1): 59–64. doi:10.1007/BF00350848. ISSN 0938-8990. PMID 1794047. S2CID 12336955.
  9. ^ Scott Durkin, A.; Maglott, Donna R.; Nierman, William C. (1992-11-01). "Chromosomal assignment of 38 human brain expressed sequence tags (ESTs) by analyzing fluorescently labeled PCR products from hybrid cell panels". Genomics. 14 (3): 808–810. doi:10.1016/S0888-7543(05)80194-6. ISSN 0888-7543. PMID 1427913.
  10. ^ Schmidt, Valentina A.; Nierman, William C.; Maglott, Donna R.; Cupit, Lisa D.; Moskowitz, Keith A.; Wainer, Jean Ann; Bahou, Wadie F. (1998). "The Human Proteinase-activated Receptor-3 (PAR-3) Gene". Journal of Biological Chemistry. 273 (24): 15061–15068. doi:10.1074/jbc.273.24.15061. ISSN 0021-9258. PMID 9614115.
  11. ^ Maglott, D. R. (2000-01-01). "NCBI's LocusLink and RefSeq". Nucleic Acids Research. 28 (1): 126–128. doi:10.1093/nar/28.1.126. PMC 102393. PMID 10592200.
  12. ^ Pruitt, Kim D.; Katz, Kenneth S.; Sicotte, Hugues; Maglott, Donna R. (2000). "Introducing RefSeq and LocusLink: curated human genome resources at the NCBI". Trends in Genetics. 16 (1): 44–47. doi:10.1016/S0168-9525(99)01882-X. PMID 10637631.
  13. ^ Pruitt, K. D. (2001-01-01). "RefSeq and LocusLink: NCBI gene-centered resources". Nucleic Acids Research. 29 (1): 137–140. doi:10.1093/nar/29.1.137. PMC 29787. PMID 11125071.
  14. ^ Pruitt, K. D.; Tatusova, T.; Maglott, D. R. (2007-01-03). "NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins". Nucleic Acids Research. 35 (Database): D61–D65. doi:10.1093/nar/gkl842. ISSN 0305-1048. PMC 1716718. PMID 17130148.
  15. ^ Maglott, D. (2004-12-17). "Entrez Gene: gene-centered information at NCBI". Nucleic Acids Research. 33 (Database issue): D54–D58. doi:10.1093/nar/gki031. ISSN 1362-4962. PMC 539985. PMID 15608257.
  16. ^ Maglott, D.; Ostell, J.; Pruitt, K. D.; Tatusova, T. (2011-01-01). "Entrez Gene: gene-centered information at NCBI". Nucleic Acids Research. 39 (Database): D52–D57. doi:10.1093/nar/gkq1237. ISSN 0305-1048. PMC 3013746. PMID 21115458.
  17. ^ Landrum, Melissa J; Lee, Jennifer M; Benson, Mark; Brown, Garth R; Chao, Chen; Chitipiralla, Shanmuga; Gu, Baoshan; Hart, Jennifer; Hoffman, Douglas; Jang, Wonhee; Karapetyan, Karen (2018-01-04). "ClinVar: improving access to variant interpretations and supporting evidence". Nucleic Acids Research. 46 (D1): D1062–D1067. doi:10.1093/nar/gkx1153. ISSN 0305-1048. PMC 5753237. PMID 29165669.
  18. ^ Landrum, Melissa J.; Lee, Jennifer M.; Riley, George R.; Jang, Wonhee; Rubinstein, Wendy S.; Church, Deanna M.; Maglott, Donna R. (2014). "ClinVar: public archive of relationships among sequence variation and human phenotype". Nucleic Acids Research. 42 (D1): D980–D985. doi:10.1093/nar/gkt1113. ISSN 0305-1048. PMC 3965032. PMID 24234437.
  19. ^ Twigger, S. (2002-01-01). "Rat Genome Database (RGD): mapping disease onto the genome". Nucleic Acids Research. 30 (1): 125–128. doi:10.1093/nar/30.1.125. PMC 99132. PMID 11752273.
  20. ^ Mouse Genome Sequencing Consortium (2002). "Initial sequencing and comparative analysis of the mouse genome". Nature. 420 (6915): 520–562. Bibcode:2002Natur.420..520W. doi:10.1038/nature01262. ISSN 0028-0836. PMID 12466850.
  21. ^ Hudson, Thomas J.; Church, Deanna M.; Greenaway, Simon; Nguyen, Huy; Cook, April; Steen, Robert G.; Van Etten, William J.; Castle, Andrew B.; Strivens, Mark A.; Trickett, Pamela; Heuston, Christine (2001). "A radiation hybrid map of mouse genes". Nature Genetics. 29 (2): 201–205. doi:10.1038/ng1001-201. ISSN 1061-4036. PMID 11586302. S2CID 27643522.
  22. ^ The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I & II Team* (2002). "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs". Nature. 420 (6915): 563–573. Bibcode:2002Natur.420..563O. doi:10.1038/nature01266. hdl:10161/11223. ISSN 0028-0836. PMID 12466851. S2CID 4347839.
  23. ^ Sea Urchin Genome Sequencing Consortium; Sodergren, E.; Weinstock, G. M.; Davidson, E. H; Cameron, R. A.; Gibbs, R. A.; Angerer, R. C.; Angerer, L. M.; Arnone, M. I.; Burgess, D. R.; Burke, R. D. (2006-11-10). "The Genome of the Sea Urchin Strongylocentrotus purpuratus". Science. 314 (5801): 941–952. Bibcode:2006Sci...314..941S. doi:10.1126/science.1133609. ISSN 0036-8075. PMC 3159423. PMID 17095691.
  24. ^ Livingston, B.T.; Killian, C.E.; Wilt, F.; Cameron, A.; Landrum, M.J.; Ermolaeva, O.; Sapojnikov, V.; Maglott, D.R.; Buchanan, A.M.; Ettensohn, C.A. (2006). "A genome-wide analysis of biomineralization-related proteins in the sea urchin Strongylocentrotus purpuratus". Developmental Biology. 300 (1): 335–348. doi:10.1016/j.ydbio.2006.07.047. PMID 16987510.
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