Docking protein 6

DOK6
Identifiers
Aliases	DOK6, DOK5L, HsT3226, docking protein 6
External IDs	OMIM: 611402; MGI: 3639495; HomoloGene: 45143; GeneCards: DOK6; OMA:DOK6 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	69,849,087 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	89,787,652 bp
RNA expression pattern
	Top expressed in
	pars compacta; ; pars reticulata; ; Brodmann area 46; ; pons; ; endothelial cell; ; middle temporal gyrus; ; ganglionic eminence; ; entorhinal cortex; ; Brodmann area 23; ; spinal ganglia;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; hippocampus proper; ; primary visual cortex; ; Cortex of frontal lobe; ; superior frontal gyrus; ; olfactory bulb; ; hypothalamus; ; striatum of neuraxis; ; cerebellar cortex; ; ganglionic eminence;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytosol;
Biological process	axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	220164
	623279
	ENSG00000206052
	ENSMUSG00000073514
	Q6PKX4
	Q2MHE5
	NM_152721
	NM_001039173
	NP_689934
	NP_001034262
	Wikidata
View/Edit Human	View/Edit Mouse

Docking protein 6 is a protein that in humans is encoded by the DOK6 gene. ^[5]

Function

DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000206052 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000073514 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Docking protein 6". Retrieved 2017-02-01.

Crowder RJ, Enomoto H, Yang M, Johnson EM, Milbrandt J (2004). "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. doi:10.1074/jbc.M403726200. PMID 15286081.
Kurotsuchi A, Murakumo Y, Jijiwa M, Kurokawa K, Itoh Y, Kodama Y, Kato T, Enomoto A, Asai N, Terasaki H, Takahashi M (2010). "Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells". Cancer Sci. 101 (5): 1147–55. doi:10.1111/j.1349-7006.2010.01520.x. PMC 11159970. PMID 20210798. S2CID 11769638.

This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000206052 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000073514 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Docking protein 6". Retrieved 2017-02-01.

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Function

References

Further reading