Deoxyribonuclease ii, lysosomal

DNASE2
Identifiers
Aliases	DNASE2, DNASE2A, DNL, DNL2, deoxyribonuclease II, lysosomal, deoxyribonuclease 2, lysosomal, AIPCS
External IDs	OMIM: 126350; MGI: 1329019; HomoloGene: 68179; GeneCards: DNASE2; OMA:DNASE2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	12,881,466 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; stromal cell of endometrium; ; external globus pallidus; ; parotid gland; ; Descending thoracic aorta; ; cardia; ; monocyte; ; vena cava; ; lateral nuclear group of thalamus; ; pars compacta;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; nuclease activity; endonuclease activity; endodeoxyribonuclease activity; hydrolase activity; deoxyribonuclease II activity;
Cellular component	lysosome; extracellular exosome; intracellular anatomical structure;
Biological process	erythrocyte differentiation; multicellular organism development; DNA metabolic process; DNA catabolic process; DNA catabolic process, endonucleolytic; apoptotic process; apoptotic DNA fragmentation; regulation of immune response;
	Sources:Amigo / QuickGO
Orthologs
	1777
	13423
	ENSG00000105612
	ENSMUSG00000003812
	O00115
	P56542
	NM_001375
	NM_010062; NM_001368295; NM_001368296
	NP_001366; NP_001366.1
	NP_034192; NP_001355224; NP_001355225
	Wikidata
View/Edit Human	View/Edit Mouse

Deoxyribonuclease II, lysosomal is a protein that in humans is encoded by the DNASE2 gene. ^[4]

Function

This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis.

Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105612 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Deoxyribonuclease II, lysosomal". Retrieved 2016-09-07.

Function

References

Further reading