Dendrocyte expressed seven transmembrane protein

DCSTAMP
Identifiers
Aliases	DCSTAMP, FIND, TM7SF4, hDC-STAMP, dendrocyte expressed seven transmembrane protein
External IDs	OMIM: 605933; MGI: 1923016; HomoloGene: 12769; GeneCards: DCSTAMP; OMA:DCSTAMP - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8q22.3 Start 104,339,087 bp End 104,356,689 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 B3.1 Start 39,609,326 bp End 39,624,334 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium amygdala right lung upper lobe of left lung islet of Langerhans tibia right uterine tube Brodmann area 9 amniotic fluid right lobe of liver Top expressed in body of femur blastocyst cochlea submandibular gland adrenal gland pituitary gland lens lip islet of Langerhans respiratory system More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component integral component of membrane endosome endoplasmic reticulum membrane membrane plasma membrane cell surface integral component of endoplasmic reticulum membrane endoplasmic reticulum endosome membrane endoplasmic reticulum-Golgi intermediate compartment membrane Biological process cellular response to interleukin-4 cell differentiation immune system process osteoclast differentiation cellular response to tumor necrosis factor membrane fusion myeloid dendritic cell differentiation positive regulation of bone resorption positive regulation of macrophage fusion cellular response to macrophage colony-stimulating factor stimulus osteoclast fusion negative regulation of cell growth positive regulation of monocyte differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81501 75766 Ensembl ENSG00000164935 ENSMUSG00000022303 UniProt Q9H295 Q7TNJ0 RefSeq (mRNA) NM_001257317 NM_030788 NM_001289506 NM_001289508 NM_001289512 NM_001289513 NM_029422 RefSeq (protein) NP_001244246 NP_110415 NP_001276435 NP_001276437 NP_001276441 NP_001276442 NP_083698 Location (UCSC) Chr 8: 104.34 – 104.36 Mb Chr 15: 39.61 – 39.62 Mb PubMed search
Wikidata
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Dendrocyte expressed seven transmembrane protein is a protein that in humans is encoded by the DCSTAMP gene.

Function

This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012].

Further reading

• Lee KY, Huang SM, Li S, Kim JM (February 2009). "Identification of differentially expressed genes in papillary thyroid cancers". Yonsei Medical Journal. 50 (1): 60–7. doi:10.3349/ymj.2009.50.1.60. PMC 2649849. PMID 19259350.
• Sakai H, Okafuji I, Nishikomori R, Abe J, Izawa K, Kambe N, Yasumi T, Nakahata T, Heike T (January 2012). "The CD40-CD40L axis and IFN-γ play critical roles in Langhans giant cell formation". International Immunology. 24 (1): 5–15. doi:10.1093/intimm/dxr088. PMID 22058328.
• Eleveld-Trancikova D, Triantis V, Moulin V, Looman MW, Wijers M, Fransen JA, Lemckert AA, Havenga MJ, Figdor CG, Janssen RA, Adema GJ (March 2005). "The dendritic cell-derived protein DC-STAMP is highly conserved and localizes to the endoplasmic reticulum". Journal of Leukocyte Biology. 77 (3): 337–43. doi:10.1189/jlb.0804441. PMID 15601667. S2CID 34646103.
• Beauregard M, Gagnon E, Guay-Bélanger S, Morissette J, Brown JP, Michou L (June 2014). "Identification of rare genetic variants in novel loci associated with Paget's disease of bone". Human Genetics. 133 (6): 755–68. doi:10.1007/s00439-013-1409-x. PMID 24370779. S2CID 15972393.
• Kim HY, Cho S, Yu J, Sung S, Kim H (August 2010). "Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT". BMB Reports. 43 (8): 547–53. doi:10.5483/bmbrep.2010.43.8.547. PMID 20797317.
• Eleveld-Trancikova D, Sanecka A, van Hout-Kuijer MA, Looman MW, Hendriks IA, Jansen BJ, Adema GJ (July 2010). "DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation". Molecular Immunology. 47 (11–12): 1963–73. doi:10.1016/j.molimm.2010.04.019. PMID 20546900.
• Zeng Z, Zhang C, Chen J (July 2013). "Lentivirus-mediated RNA interference of DC-STAMP expression inhibits the fusion and resorptive activity of human osteoclasts". Journal of Bone and Mineral Metabolism. 31 (4): 409–16. doi:10.1007/s00774-013-0434-0. PMID 23525827. S2CID 22750579.
• Hartgers FC, Looman MW, van der Woning B, Merkx GF, Figdor CG, Adema GJ (March 2001). "Genomic organization, chromosomal localization, and 5' upstream region of the human DC-STAMP gene". Immunogenetics. 53 (2): 145–9. doi:10.1007/s002510100302. PMID 11345591. S2CID 2780913.
• Chiu YH, Mensah KA, Schwarz EM, Ju Y, Takahata M, Feng C, McMahon LA, Hicks DG, Panepento B, Keng PC, Ritchlin CT (January 2012). "Regulation of human osteoclast development by dendritic cell-specific transmembrane protein (DC-STAMP)". Journal of Bone and Mineral Research. 27 (1): 79–92. doi:10.1002/jbmr.531. PMC 3304467. PMID 21987375.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.