Deborah Leckband
Deborah Elaine Leckband | |
|---|---|
| Born | 1959 (age 64–65) |
| Alma mater | Cornell University Humboldt State University |
| Scientific career | |
| Institutions | University of Illinois at Urbana-Champaign Massachusetts Institute of Technology University of California, Santa Barbara |
| Thesis | A kinetic study of nucleotide interactions with chloroplast coupling factor (1988) |
Deborah E. Leckband (born 1959) is an American chemist who is the Reid T. Milner Professor of Chemical Sciences and professor of chemistry at the University of Illinois Urbana-Champaign. She works on biomaterials, tissue engineering and the nano mechanics of biomolecules. She is a Fellow of the American Institute for Medical and Biological Engineering, the American Association for the Advancement of Science, the Biomedical Engineering Society and the American Chemical Society.
Early life and education
[edit]Leckband was born in Urbana, Illinois.[1] She was an undergraduate student at the Humboldt University of Berlin.[2] She moved to Cornell University for her doctoral research, where she studied nucleotide interactions.[3] She then moved to Massachusetts Institute of Technology, where she worked alongside Robert S. Langer on the immobilization of proteins.[4] She was a postdoctoral researcher with Jacob Israelachvili at the University of California, Santa Barbara, during which she became interested in surface science and how it impacts biology and cell adhesion.[5][6]
Research and career
[edit]Leckband joined the University of Illinois Urbana-Champaign in 1988.[1] She develops experimental approaches to understand the nanomechanics of biomolecules and cell adhesion.[7] She is particularly interested in surface science in biological systems, and the fundamental mechanisms that drive cell adhesion.[8] These surfaces may include the coatings on drug containers, the surfaces of biosensors and other bioelectronic devices, and contact lenses. She has studied how the physio-chemical properties of surfaces impact biological function. Her research has identified new materials for optimized drug delivery and non-fouling contact lenses.[6] She has shown it is possible to engineer "smart" coatings to selectively modify interfacial responses.[6]
Leckband worked with Martin Gruebele to understand the stability of proteins in situ at sub-micron resolution. Their research has shown that polymers moderate protein function, which helps to design biomaterials with optimized stability and activity.[9]
Leckband has shown that the velcro-like cadherins are not only involved with holding cells together, but that they perform critical functions when they are under tension.[10][11] Under tensional stress, the cadherin growth factor interaction is disrupted, which switches on tissue growth signalling pathways.[12]
Awards and honors
[edit]- 2004 Britton Chance Distinguished Lecturer[13]
- 2005 Elected Fellow of the American Institute for Medical and Biological Engineering[14]
- 2005 Elected Fellow of the American Association for the Advancement of Science[15]
- 2009 Elected Fellow of the American Chemical Society[16]
- 2014 Elected Fellow of the Biomedical Engineering Society[17]
- 2021 Langmuir Lectureship[5]
Selected publications
[edit]- Leckband D; Israelachvili J (May 1, 2001). "Intermolecular forces in biology". Quarterly Reviews of Biophysics. 34 (2): 105–267. doi:10.1017/S0033583501003687. ISSN 0033-5835. PMID 11771120. Wikidata Q34480853.
- Quint le Duc; Quanming Shi; Iris Blonk; Arnoud Sonnenberg; Ning Wang; Deborah Leckband; Johan De Rooij (June 1, 2010). "Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner". Journal of Cell Biology. 189 (7): 1107–1115. doi:10.1083/JCB.201001149. ISSN 0021-9525. PMC 2894457. PMID 20584916. Wikidata Q33950292.
- D Leckband (January 1, 2000). "Measuring the forces that control protein interactions". Annual Review of Biophysics and Biomolecular Structure. 29: 1–26. doi:10.1146/ANNUREV.BIOPHYS.29.1.1. ISSN 1056-8700. PMID 10940241. Wikidata Q30902051.
References
[edit]- ^ a b "Deborah E. Leckband | WorldCat.org". www.worldcat.org. Retrieved March 26, 2023.
- ^ "Deborah Leckband". www.aiche.org. March 17, 2021. Retrieved March 26, 2023.
- ^ Leckband, Deborah Elaine (1988). "A kinetic study of nucleotide interactions with chloroplast coupling factor".
- ^ Leckband, Deborah; Langer, Robert (February 5, 1991). "An approach for the stable immobilization of proteins". Biotechnology and Bioengineering. 37 (3): 227–237. doi:10.1002/bit.260370305. ISSN 0006-3592. PMID 18597360. S2CID 37474131.
- ^ a b author//author/marcus-anderson (July 14, 2021). "2021 Langmuir Lectureship Award Winners Announced". ACS Publications Chemistry Blog. Retrieved March 26, 2023.
{{cite web}}:|last=has generic name (help) - ^ a b c "Deborah E. Leckband | Chemistry at Illinois". chemistry.illinois.edu. Retrieved March 26, 2023.
- ^ Leckband, Deborah (August 1995). "The surface force apparatus — a tool for probing molecular protein interactions". Nature. 376 (6541): 617–618. Bibcode:1995Natur.376..617L. doi:10.1038/376617a0. ISSN 1476-4687. PMID 7637815. S2CID 28621303.
- ^ Communications, Grainger Engineering Office of Marketing and. "Leckband cell-to-cell force sensing research published in Journal of Cell Science". chbe.illinois.edu. Retrieved March 26, 2023.
- ^ Communications, Grainger Engineering Office of Marketing and. "Drs. Leckband, Gruebele awarded NSF grant". chbe.illinois.edu. Retrieved March 26, 2023.
- ^ Sullivan, Brendan; Light, Taylor; Vu, Vinh; Kapustka, Adrian; Hristova, Kalina; Leckband, Deborah (January 25, 2022). "Mechanical disruption of E-cadherin complexes with epidermal growth factor receptor actuates growth factor–dependent signaling". Proceedings of the National Academy of Sciences. 119 (4): e2100679119. Bibcode:2022PNAS..11900679S. doi:10.1073/pnas.2100679119. ISSN 0027-8424. PMC 8794882. PMID 35074920.
- ^ "'Molecular Velcro' enables tissues to sense, react to mechanical force". EurekAlert!. Retrieved March 26, 2023.
- ^ Yoksoulian, Lois. "'Molecular Velcro' enables tissues to sense, react to mechanical force". news.illinois.edu. Retrieved March 26, 2023.
- ^ "Chance Lecture". Retrieved March 26, 2023.
- ^ "Deborah Leckband, Ph.D. COF-0558 - AIMBE". Retrieved March 26, 2023.
- ^ "Deborah Leckband was elected a Fellow of the American Association for the Advancement of Science. | Chemistry at Illinois". chemistry.illinois.edu. Retrieved March 26, 2023.
- ^ Kloeppel, James E. "Four professors at Illinois elected fellows of American Chemical Society". news.illinois.edu. Retrieved March 26, 2023.
- ^ "List of Fellows - Biomedical Engineering Society". www.bmes.org. Retrieved March 26, 2023.
| Authority control databases: Academics |
|---|
- 1959 births
- Living people
- American women chemists
- 20th-century American chemists
- 20th-century American women scientists
- 21st-century American chemists
- 21st-century American women scientists
- People from Urbana, Illinois
- Scientists from Illinois
- Humboldt University of Berlin alumni
- Cornell University alumni
- Massachusetts Institute of Technology people
- University of California, Santa Barbara people
- University of Illinois Urbana-Champaign faculty
- Fellows of the American Institute for Medical and Biological Engineering
- Fellows of the American Association for the Advancement of Science
- Fellows of the American Chemical Society
- Fellows of the Biomedical Engineering Society