David Eisenberg
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David Eisenberg | |
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Born | Chicago, Illinois, US | March 15, 1939
Alma mater | Harvard University (undergraduate) The Queen's College, Oxford (postgraduate) |
Awards | Harvey Prize (2008) ISCB Senior Scientist Award (2013)[1] |
Scientific career | |
Fields | Proteins[2] Amyloid[3] Structural biology[4][5][6] |
Institutions | Howard Hughes Medical Institute University of Oxford University of California, Los Angeles Harvard University California Institute of Technology Princeton University |
Thesis | Some problems in the electronic structure of molecules (1965) |
Doctoral advisor | Charles Coulson[citation needed] |
Notable students |
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Website |
David S. Eisenberg (born 15 March 1939[citation needed]) is an American biochemist and biophysicist best known for his contributions to structural biology and computational molecular biology. He has been a professor at the University of California, Los Angeles since the early 1970s and was director of the UCLA-DOE Institute for Genomics & Proteomics, as well as a member of the California NanoSystems Institute (CNSI) at UCLA.[9][10][11][12][13][14][15]
Education
[edit]Eisenberg attended Harvard University and graduated in 1961 with an A.B. in Biochemical Sciences. He went on to the University of Oxford, where he was awarded a D.Phil in 1965[16] for research supervised by Charles Coulson.
Research
[edit]Eisenberg's current research focuses on the structural biology of amyloidogenic proteins, while his computational efforts largely center on the development of bioinformatic/proteomic methodologies for elucidation and analysis of protein interaction networks. His research group hosts the Database of Interacting Proteins.[17]
Career
[edit]- Postdoctoral research, Princeton University (1964–1966; with Walter Kauzmann)
- Postdoctoral research, California Institute of Technology (1966–1969; with Richard E. Dickerson)
- Professor, Department of Chemistry & Biochemistry, UCLA, USA (1969–Present)
- Professor, Department of Biological Chemistry, UCLA Medical School
- Director, UCLA-DOE Institute for Genomics & Proteomics (1993–2014)
- Member, California NanoSystems Institute (CNSI), UCLA
- Investigator, Howard Hughes Medical Institute (2001–Present)
Awards
[edit]He was the recipient of Harvey Prize (Human Health) 2008 in recognition of his contributions in unfolding the structure of amyloid fibrils. The award was presented to him at a ceremony that took place on March 23, 2009 at the Technion. This recently recognized protein state provides opportunities to understand cells in health and disease.[18]
- 1961 - L.J. Henderson Prize
- 1958-1960 - Harvard College Honorary Scholarships
- 1961-1964 - Rhodes Scholarship
- 1972-1977 - USPHS Career Development Award
- 1975 - UCLA Distinguished Teaching Award
- 1982 - McCoy Award of the UCLA Department of Chemistry and Biochemistry for innovative research
- 1989 - Member, National Academy of Sciences (Biophysics & Computational Biology section)[19]
- 1992 - Pierce Award of the Immunotoxin Society
- 1996 - Protein Society Stein & Moore Award
- 1998 - American Chemical Society Repligen Corporation Award in Chemistry of Biological Processes
- 2000 - Investigator, Howard Hughes Medical Institute
- 2000 - Amgen Award of the Protein Society
- 2001 - Fellow, American Association for the Advancement of Science
- 2003 - Member, American Philosophical Society[20]
- 2004 - UCLA Glenn T. Seaborg Medal[21]
- 2005 - Harvard University's Westheimer Medal
- 2008 - ACS Nobel Laureate Signature Award for Graduate Education in Chemistry (as preceptor, student was Rebecca Anne Nelson)
- 2013 - ISCB (International Society for Computational Biology) Senior Scientist Award
- 2020 - Passano Award[22]
References
[edit]- ^ Fogg, C. N.; Kovats, D. E. (2013). "International Society for Computational Biology Honors David Eisenberg with 2013 Accomplishment by a Senior Scientist Award". PLOS Computational Biology. 9 (6): e1003116. Bibcode:2013PLSCB...9E3116F. doi:10.1371/journal.pcbi.1003116. PMC 3681620.
- ^ Eisenberg, D.; McLachlan, A. D. (1986). "Solvation energy in protein folding and binding". Nature. 319 (6050): 199–203. Bibcode:1986Natur.319..199E. doi:10.1038/319199a0. PMID 3945310. S2CID 21867582.
- ^ Balbirnie, M.; Grothe, R.; Eisenberg, D. S. (2001). "An amyloid-forming peptide from the yeast prion Sup35 reveals a dehydrated beta -sheet structure for amyloid". Proceedings of the National Academy of Sciences. 98 (5): 2375–2380. Bibcode:2001PNAS...98.2375B. doi:10.1073/pnas.041617698. PMC 30146. PMID 11226247.
- ^ Lüthy, R.; Bowie, J. U.; Eisenberg, D. (1992). "Assessment of protein models with three-dimensional profiles". Nature. 356 (6364): 83–85. Bibcode:1992Natur.356...83L. doi:10.1038/356083a0. PMID 1538787. S2CID 4369151.
- ^ Chapman, M. S.; Suh, S. W.; Curmi, P. M.; Cascio, D.; Smith, W. W.; Eisenberg, D. S. (1988). "Tertiary structure of plant RuBisCO: Domains and their contacts". Science. 241 (4861): 71–74. Bibcode:1988Sci...241...71C. doi:10.1126/science.3133767. PMID 3133767.
- ^ David Eisenberg publications indexed by Google Scholar
- ^ "Former Lab Members | David Eisenberg's Lab".
- ^ "Former Lab Members | David Eisenberg's Lab".
- ^ HHMI profile of David Eisenberg
- ^ The Eisenberg research lab at UCLA
- ^ UCLA-DOE Institute for Genomics & Proteomics
- ^ David Eisenberg’s speech during the Harvey Prize ceremony on YouTube
- ^ Eisenberg, David; Kauzmann, Walter (2005). The structure and properties of water. Oxford: Clarendon Press. ISBN 0-19-857026-0.
- ^ David Eisenberg publications indexed by Microsoft Academic
- ^ David Eisenberg's publications indexed by the Scopus bibliographic database. (subscription required)
- ^ Eisenberg, David J. (1965). Some problems in the electronic structure of molecules (PhD thesis). University of Oxford.
- ^ Salwinski, L.; Miller, C. S.; Smith, A. J.; Pettit, F. K.; Bowie, J. U.; Eisenberg, D. (2004). "The Database of Interacting Proteins: 2004 update". Nucleic Acids Research. 32 (90001): D449–D451. doi:10.1093/nar/gkh086. PMC 308820. PMID 14681454.
- ^ Harvey Prize Award
- ^ "David S. Eisenberg". www.nasonline.org. Retrieved 2021-09-14.
- ^ "APS Member History". search.amphilsoc.org. Retrieved 2021-09-14.
- ^ "UCLA Glenn T. Seaborg Symposium - Previous Recipients". www.seaborg.ucla.edu. Retrieved 2024-01-05.
- ^ Passano Award 2020
- 1939 births
- Living people
- Harvard University alumni
- Howard Hughes Medical Investigators
- American biophysicists
- Jewish American scientists
- University of California, Los Angeles faculty
- Members of the United States National Academy of Sciences
- Fellows of the International Society for Computational Biology
- Members of the American Philosophical Society
- 21st-century American Jews
- Members of the National Academy of Medicine
- Structural biologists