David B. Weiner
David B. Weiner is an American biomedical researcher at The Wistar Institute in Philadelphia, where he serves as executive vice president and director of the Vaccines and Immunotherapy Center[1]. Weiner also holds the titles of WW Smith Distinguished Chair in Cancer Research and professor emeritus, Perelman School of Medicine at the University of Pennsylvania[2].
Biography
[edit]Weiner is from Brooklyn, NY, and graduated with a B.S. in biology from SUNY at Stony Brook, NY. He earned both his M.S. in Biology and Ph.D. in development biology from the University of Cincinnati[3].
Weiner is regarded as one of the founders of the field of DNA vaccines and detailed many of the initial properties of the technology.[4] His laboratory described DNA vaccine technology as an approach to HIV vaccine development and for the immune therapy of cancer, and in 1998, Weiner and his associates were the first to move DNA vaccines into human clinical trials.[5][6] The Weiner laboratory also reports on adjuvant effects in vaccination protocols by targeting the checkpoint inhibitor pathways, among others.
Weiner has served as president of the International Society for Vaccines (2018-2020), and as chair of the Gene Therapy and Vaccine Training Program at the University of Pennsylvania from 2004-2016, before joining the Wistar Institute.[7][8] He and his lab had a cameo appearance in the 1993 movie Philadelphia starring Tom Hanks.[9]
Research
[edit]Weiner’s research focuses on translational applications of molecular immunology. His early work developed monoclonal antibodies as therapeutics targeting tumors and infections, and the lab continues to pursue nucleic acid vaccines and immunotherapies.[10] The lab has been involved in several clinical trials.[11] Weiner has published more than 500 papers, chapters, and articles.[12]
References
[edit]- ^ "David B". Default. Retrieved 2024-11-19.
- ^ "David B". Default. Retrieved 2024-11-19.
- ^ "David B". Default. Retrieved 2024-11-19.
- ^ McCullough, Marie (2020-06-26). "Coronavirus could be the turning point for a vaccine technology 30 years in the making". inquirer.com. Retrieved 2024-11-19.
- ^ "Gene inoculation generates immune responses against human immunodeficiency virus type 1". Proceedings of the National Academy of Sciences.
- ^ "First Human Trial of a DNA-Based Vaccine for Treatment of Human Immunodeficiency Virus Type 1 Infection: Safety and Host Response". The Journal of Infectious Diseases.
- ^ "Officers and Board Members 2018 – 2019".
- ^ Research, Prof David Weiner | WW Smith Endowed Chair in Cancer; Center, Director Wistar Vaccine; Institute, EVP of The Wistar; Medicine, Professor Emeritus University of Pennsylvania School of (2016-03-24). "Prof David Weiner | Emerging Disease Vaccines". World Emerging Diseases Conference 2016. Retrieved 2024-11-19.
- ^ McCullough, Marie (2020-06-26). "Coronavirus could be the turning point for a vaccine technology 30 years in the making". inquirer.com. Retrieved 2024-11-19.
- ^ Mccallus, Daniel E.; Ugen, Kenneth E.; Sato, Alice I.; Williams, William V.; Weiner, David B. (January 1992). "Construction of a Recombinant Bacterial Human CD4 Expression System Producing a Bioactive CD4 Molecule". Viral Immunology. 5 (2): 163–172. doi:10.1089/vim.1992.5.163. ISSN 0882-8245.
- ^ "weiner, d.b. AND "trial" - Search Results - PubMed". PubMed. Retrieved 2024-11-19.
- ^ "Weiner DB - Search Results - PubMed". PubMed. Retrieved 2024-11-19.