Daturaolone

Daturaolone
Names
	Preferred IUPAC name (4aR,5R,6aR,6bS,8aR,12aR,14aR,14bR)-5-Hydroxy-4,4,6a,6b,8a,14b-hexamethyl-1,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-octadecahydropicen-3(2H)-one
Identifiers
CAS Number	41498-80-0;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL2005473;
ChemSpider	109521;
PubChem CID	122859;
CompTox Dashboard (EPA)	DTXSID70961770 ;
	InChI InChI=1S/C30H48O2/c1-25(2)13-14-27(5)15-16-29(7)19(20(27)17-25)9-10-22-28(6)12-11-23(32)26(3,4)24(28)21(31)18-30(22,29)8/h9,20-22,24,31H,10-18H2,1-8H3/t20-,21+,22+,24-,27+,28+,29+,30+/m0/s1 Key: YCTXVPCDHZMBHX-QCDSSADQSA-N;
	SMILES CC1(CCC2(CCC3(C(=CCC4C3(CC(C5C4(CCC(=O)C5(C)C)C)O)C)C2C1)C)C)C;
Properties
Chemical formula	C30H48O2
Molar mass	440.712 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Daturaolone is a pentacyclic oleanane triterpenoid,^[1] also known as 3-oxo-6-β-hydroxy-β-amyrin,^[2] found in Datura species such as Datura stramonium^[3] and Datura innoxia.^[4]

History

It was isolated for the first time from Solanum arundo.^[5]

Structure

Daturaolone contains five rings with a ketone group and a hydroxyl group, which may be essential for its bioactivities. The structure was deduced through mass spectroscopy and ¹H NMR spectroscopy.^[6]

Functions

Daturaolone isolated from Datura metel Linnaeus has been found to have anti-fungal and anti-bacterial activities. When tested against bacterial strains such as Klebsiella pneumoniae and S. aureus, daturaolone was shown to inhibit bacterial growth.^[7]

References

^ Baig, Muhammad Waleed; Fatima, Humaira; Akhtar, Nosheen; Hussain, Hidayat; Okla, Mohammad K.; Al-Hashimi, Abdulrahman; Al-Qahtani, Wahidah H.; AbdElgawad, Hamada; Haq, Ihsan-ul (2021-11-30). "Anti-Inflammatory Potential of Daturaolone from Datura innoxia Mill.: In Silico, In Vitro and In Vivo Studies". Pharmaceuticals. 14 (12): 1248. doi:10.3390/ph14121248. ISSN 1424-8247. PMC 8708807. PMID 34959649.
^ Bawazeer, Saud; Rauf, Abdur; Bawazeer, Sami (2020). "Gastrointestinal Motility, Muscle Relaxation, Antipyretic and Acute Toxicity Screening of Amyrin Type Triterpenoid (Daturaolone) Isolated From Datura metel Linnaeus (Angel's Trumpet) Fruits". Frontiers in Pharmacology. 11: 544794. doi:10.3389/fphar.2020.544794. ISSN 1663-9812. PMC 7546419. PMID 33101017.
^ Li J, Lin B, Wang G, Gao H, Qin M (February 2012). "[Chemical constituents of Datura stramonium seeds]". Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica (in Chinese). 37 (3): 319–22. PMID 22568232.
^ Kocór M, Pyrek JS, Atal CK, Bedi KL, Sharma BR (October 1973). "Triterpenes of Datura innoxia Mill. Structure of daturadiol and daturaolone". The Journal of Organic Chemistry. 38 (21): 3685–8. doi:10.1021/jo00961a005. PMID 4745874.
^ Grace MH, Saleh MM (August 1996). "Hepato-protective effect of daturaolone isolated from Solanum arundo". Die Pharmazie. 51 (8): 593–5. PMID 8794471.
^ Grace, M. H.; Saleh, M. M. (August 1996). "Hepato-protective effect of daturaolone isolated from Solanum arundo". Die Pharmazie. 51 (8): 593–595. ISSN 0031-7144. PMID 8794471.
^ Bawazeer, Sami; Rauf, Abdur (2021-09-18). "In Vitro Antibacterial and Antifungal Potential of Amyrin-Type Triterpenoid Isolated from Datura metel Linnaeus". BioMed Research International. 2021: 1543574. doi:10.1155/2021/1543574. ISSN 2314-6133. PMC 8476240. PMID 34589544.

[1] Baig, Muhammad Waleed; Fatima, Humaira; Akhtar, Nosheen; Hussain, Hidayat; Okla, Mohammad K.; Al-Hashimi, Abdulrahman; Al-Qahtani, Wahidah H.; AbdElgawad, Hamada; Haq, Ihsan-ul (2021-11-30). "Anti-Inflammatory Potential of Daturaolone from Datura innoxia Mill.: In Silico, In Vitro and In Vivo Studies". Pharmaceuticals. 14 (12): 1248. doi:10.3390/ph14121248. ISSN 1424-8247. PMC 8708807. PMID 34959649.

[2] Bawazeer, Saud; Rauf, Abdur; Bawazeer, Sami (2020). "Gastrointestinal Motility, Muscle Relaxation, Antipyretic and Acute Toxicity Screening of Amyrin Type Triterpenoid (Daturaolone) Isolated From Datura metel Linnaeus (Angel's Trumpet) Fruits". Frontiers in Pharmacology. 11: 544794. doi:10.3389/fphar.2020.544794. ISSN 1663-9812. PMC 7546419. PMID 33101017.

[pmid22568232-3] Li J, Lin B, Wang G, Gao H, Qin M (February 2012). "[Chemical constituents of Datura stramonium seeds]". Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica (in Chinese). 37 (3): 319–22. PMID 22568232.

[pmid4745874-4] Kocór M, Pyrek JS, Atal CK, Bedi KL, Sharma BR (October 1973). "Triterpenes of Datura innoxia Mill. Structure of daturadiol and daturaolone". The Journal of Organic Chemistry. 38 (21): 3685–8. doi:10.1021/jo00961a005. PMID 4745874.

[pmid8794471-5] Grace MH, Saleh MM (August 1996). "Hepato-protective effect of daturaolone isolated from Solanum arundo". Die Pharmazie. 51 (8): 593–5. PMID 8794471.

[6] Grace, M. H.; Saleh, M. M. (August 1996). "Hepato-protective effect of daturaolone isolated from Solanum arundo". Die Pharmazie. 51 (8): 593–595. ISSN 0031-7144. PMID 8794471.

[7] Bawazeer, Sami; Rauf, Abdur (2021-09-18). "In Vitro Antibacterial and Antifungal Potential of Amyrin-Type Triterpenoid Isolated from Datura metel Linnaeus". BioMed Research International. 2021: 1543574. doi:10.1155/2021/1543574. ISSN 2314-6133. PMC 8476240. PMID 34589544.

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[2]

[3]

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[6]

[7]

History

Structure

Functions

See also

References